Organism : Clostridium acetobutylicum | Module List :
Predicted phosphohydrolase, Icc family (NCBI ptt file)
Functional Annotations (1)
|hydrolase activity||go/ molecular_function|
Regulation information for CAC1078(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC1078
|hydrolase activity||go/ molecular_function|
Module neighborhood information for CAC1078
|Gene||Common Name||Description||Module membership|
|CAC0081||agrA||Accessory gene regulator protein A (NCBI ptt file)||53, 86|
|CAC0437||CAC0437||Sensory transduction histidine kinase (NCBI ptt file)||53, 352|
|CAC0639||CAC0639||Flagellar biosynthesis related protein (NCBI ptt file)||53, 298|
|CAC0656||CAC0656||Predicted transposase (3' fragment) (NCBI ptt file)||205, 267|
|CAC0657||CAC0657||Predicted transposase (5' fragment) (NCBI ptt file)||205, 267|
|CAC0716||smpB||TmRNA-binding protein SmpB (NCBI ptt file)||53, 304|
|CAC0735||CAC0735||Transmembrane protein, ortholog TM1408 (NCBI ptt file)||231, 267|
|CAC0800||ubiA||4-hydroxybenzoate octaprenyltranferase related protein (NCBI ptt file)||183, 267|
|CAC0831||CAC0831||Sensory transduction histidine kinase (NCBI ptt file)||38, 53|
|CAC0881||CAC0881||Hypothetical protein (NCBI ptt file)||267, 344|
|CAC0910||CAC0910||Probably cellulosomal scaffolding protein precursor, secreted; cellulose-binding and cohesin domain (NCBI ptt file)||53, 63|
|CAC0912||CAC0912||Possible non-processive endoglucanase family 5, secreted; CelA homolog secreted; dockerin domain (NCBI ptt file)||53, 111|
|CAC0925||CAC0925||TPR-repeat-containing protein (NCBI ptt file)||53, 270|
|CAC1003||CAC1003||Superfamily I DNA helicase (rep-like helicase) (NCBI ptt file)||267, 317|
|CAC1009||CAC1009||Cell wall biogenesis enzyme (N-terminal domain related to N-Acetylmuramoyl-L-alanine amidase and C-terminal domain related to L-alanoyl-D-glutamate peptidase); peptodoglycan-binding domain (NCBI ptt file)||155, 267|
|CAC1068||CAC1068||Hypothetical protein, CF-25 family (NCBI ptt file)||176, 267|
|CAC1078||CAC1078||Predicted phosphohydrolase, Icc family (NCBI ptt file)||53, 267|
|CAC1169||CAC1169||Hypothetical protein (NCBI ptt file)||53, 134|
|CAC1170||xerD||Integrase/recombinase (xerD/xerC family) (NCBI ptt file)||53, 267|
|CAC1228||cisA||Site-specific DNA recombinase (NCBI ptt file)||26, 53|
|CAC1351||CAC1351||Periplasmic sugar-binding protein (NCBI ptt file)||24, 267|
|CAC1452||CAC1452||MDR-type permease (NCBI ptt file)||26, 53|
|CAC1472||CAC1472||Amino acid permease (NCBI ptt file)||40, 267|
|CAC1555||CAC1555||Flagellin (NCBI ptt file)||53, 69|
|CAC1770||CAC1770||RNA polymerase sigma factor, SigK-like (NCBI ptt file)||53, 68|
|CAC1772||sacB1||Levansucrase (NCBI ptt file)||53, 148|
|CAC1856||CAC1856||Ribonuclease HI (NCBI ptt file)||238, 267|
|CAC1914||CAC1914||Hypothetical protein (NCBI ptt file)||11, 53|
|CAC1994||moaB||Molybdopterin biosynthesis enzyme, MoaB (NCBI ptt file)||53, 68|
|CAC2013||CAC2013||Hypothetical protein (NCBI ptt file)||53, 97|
|CAC2015||CAC2015||Hypothetical protein (NCBI ptt file)||53, 97|
|CAC2098||CAC2098||Hypothetical protein (NCBI ptt file)||267, 312|
|CAC2133||CAC2133||Uncharacterized conserved protein, YLLB B.subtilis family (NCBI ptt file)||11, 53|
|CAC2336||CAC2336||TPR repeats containing protein (NCBI ptt file)||53, 294|
|CAC2393||CAC2393||Uncharacterized ABC transporter, ATPase component (NCBI ptt file)||231, 267|
|CAC2467||CAC2467||Hypothetical protein (NCBI ptt file)||110, 267|
|CAC2494||CAC2494||Predicted membrane protein (NCBI ptt file)||53, 86|
|CAC2504||CAC2504||Hypothetical protein (NCBI ptt file)||4, 53|
|CAC2508||CAC2508||Nitroreductase family protein (NCBI ptt file)||29, 267|
|CAC2597||CAC2597||Hypothetical protein (NCBI ptt file)||60, 267|
|CAC2599||CAC2599||Hypothetical protein (NCBI ptt file)||110, 267|
|CAC2679||CAC2679||Pullulanase (NCBI ptt file)||267, 279|
|CAC2706||CAC2706||Uncharacterized conserved membrane protein, DedA family (NCBI ptt file)||53, 273|
|CAC2715||CAC2715||Hypothetical protein (NCBI ptt file)||26, 53|
|CAC2727||CAC2727||Predicted PHP family hydrolase (NCBI ptt file)||53, 278|
|CAC2988||CAC2988||Uncharacterized conserved protein, YABE B.subtilis ortholog (NCBI ptt file)||267, 345|
|CAC3215||prsA||Parvulin-like peptidyl-prolyl isomerase, PRSA B.subtilis ortholog (NCBI ptt file)||53, 59|
|CAC3535||CAC3535||Type II restriction enzyme, methylase subunit (NCBI ptt file)||53, 222|
|CAC3565||CAC3565||Uncharacterized secreted protein, containing cell adhesion domain (NCBI ptt file)||205, 267|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
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