Organism : Clostridium acetobutylicum | Module List :
Probable cation efflux pump (multidrug resistance protein) (NCBI ptt file)
Functional Annotations (6)
|Na+-driven multidrug efflux pump||cog/ cog|
|drug transmembrane transport||go/ biological_process|
|drug transmembrane transporter activity||go/ molecular_function|
|antiporter activity||go/ molecular_function|
Regulation information for CAC1611(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC1611
Module neighborhood information for CAC1611
|Gene||Common Name||Description||Module membership|
|CAC0008||CAC0008||Predicted HD superfamily hydrolase (NCBI ptt file)||8, 130|
|CAC0028||hydA||Hydrogene dehydrogenase (NCBI ptt file)||8, 130|
|CAC0077||CAC0077||Conserved membrane protein, possible homolog of CAAX-like membrane endopeptidase (NCBI ptt file)||297, 317|
|CAC0616||CAC0616||Predicted membrane protein (NCBI ptt file)||8, 162|
|CAC0682||nrgA||Ammonium transporter (membrane protein nrgA) (NCBI ptt file)||8, 297|
|CAC0683||CAC0683||Hypothetical protein (NCBI ptt file)||8, 215|
|CAC0744||CAC0744||Na+/H+ antiporter, ortholog YQKI B.subtilis (NCBI ptt file)||252, 297|
|CAC0767||CAC0767||Fe-S oxidoreductase (NCBI ptt file)||8, 116|
|CAC0775||CAC0775||ATP-utilizing enzyme of the PP-loop superfamily (NCBI ptt file)||8, 130|
|CAC1097||CAC1097||Hypothetical protein (NCBI ptt file)||297, 317|
|CAC1307||CAC1307||Hypothetical protein (NCBI ptt file)||51, 297|
|CAC1611||CAC1611||Probable cation efflux pump (multidrug resistance protein) (NCBI ptt file)||8, 297|
|CAC1720||CAC1720||Flavoprotein involved in panthothenate metabolism, YLOI B.subtilis ortholog (NCBI ptt file)||8, 172|
|CAC1757||CAC1757||RimM protein, required for 16S rRNA processing (NCBI ptt file)||76, 297|
|CAC1758||trmD||TRNA-(guanine-N1)-methyltransferase, TrmD (NCBI ptt file)||76, 297|
|CAC1821||purB||Adenylosuccinate lyase (NCBI ptt file)||106, 297|
|CAC2265||CAC2265||Uncharacterized conserved membrane protein (NCBI ptt file)||106, 297|
|CAC2266||CAC2266||Uncharacterized conserved membrane protein (fragment) (NCBI ptt file)||106, 297|
|CAC2277||secF||Preprotein translocase subunit SecF (NCBI ptt file)||8, 149|
|CAC2278||secD||Preprotein translocase subunits SecD (NCBI ptt file)||8, 179|
|CAC2279||CAC2279||Heme biosynthesis (nirJ-2) family protein (NCBI ptt file)||8, 179|
|CAC2312||CAC2312||Rhamnosyl transferase, rfbQ (NCBI ptt file)||8, 130|
|CAC2313||CAC2313||Glycosyltransferase (NCBI ptt file)||8, 130|
|CAC2314||CAC2314||Membrane protein involved in the export of O-antigen and teichoic acid, RfbX family (NCBI ptt file)||8, 130|
|CAC2374||oppC||Oligopeptide ABC-type transporter, permease component OPPC (NCBI ptt file)||224, 297|
|CAC2375||oppB||Oligopeptide ABC-type transporter, permease (NCBI ptt file)||224, 297|
|CAC2398||folC||Folylpolyglutamate synthase (NCBI ptt file)||296, 297|
|CAC2399||vals||Valyl-tRNA synthetase (NCBI ptt file)||296, 297|
|CAC2849||CAC2849||Proline/glycine betaine ABC-type transport system, permease component fused to periplasmic component (NCBI ptt file)||8, 297|
|CAC2850||CAC2850||Proline/glycine betaine ABC-type transport system, ATPase component (NCBI ptt file)||8, 84|
|CAC2925||CAC2925||HD superfamily hydrolase (NCBI ptt file)||286, 297|
|CAC2926||sul||Dihydropteroate synthase (NCBI ptt file)||34, 297|
|CAC2927||folA/folK||Dihydroneopterin aldolase fused to 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (NCBI ptt file)||286, 297|
|CAC3104||rpoA||DNA-dependent RNA polymerase alpha subunit (NCBI ptt file)||8, 304|
|CAC3262||CAC3262||ATPase with chaperone activity, ATP-binding domain, diverged (NCBI ptt file)||224, 297|
|CAC3390||CAC3390||Response regulator (CheY-like receiver domain containing) (NCBI ptt file)||51, 297|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
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Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
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