Organism : Clostridium acetobutylicum | Module List :
Regulation information for CAC1732(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Module neighborhood information for CAC1732
|Gene||Common Name||Description||Module membership|
|CAC0003||CAC0003||Small conserved protein, ortholog of YAAA B.subtilis (NCBI ptt file)||105, 278|
|CAC0024||CAC0024||Membrane protein, related to Actinobacillus protein (1944168) (NCBI ptt file)||38, 295|
|CAC0739||CAC0739||Predicted membrane protein (NCBI ptt file)||105, 142|
|CAC0831||CAC0831||Sensory transduction histidine kinase (NCBI ptt file)||38, 53|
|CAC0832||CAC0832||Fusion: transcriptional regulator and conserved domain (NCBI ptt file)||38, 320|
|CAC0842||CAC0842||Hypothetical protein, CF-28 family (NCBI ptt file)||38, 56|
|CAC0947||CAC0947||Predicted membrane protein, hemolysin III homolog (NCBI ptt file)||38, 273|
|CAC0964||CAC0964||Hypothetical protein (NCBI ptt file)||105, 210|
|CAC0979||CAC0979||Uncharacterized protein containing two CBS domains (NCBI ptt file)||87, 105|
|CAC0987||CAC0987||Hypothetical protein (NCBI ptt file)||38, 134|
|CAC1021||CAC1021||Predicted Fe-S oxidoreductases (NCBI ptt file)||28, 105|
|CAC1055||CAC1055||Hypothetical protein (NCBI ptt file)||38, 367|
|CAC1100||CAC1100||Secreted protein, similar to catalytic domain of murein transglycosylase (NCBI ptt file)||38, 56|
|CAC1269||CAC1269||Cation transport ATPase (NCBI ptt file)||30, 105|
|CAC1511||CAC1511||FNR-like catabolite gene activator (c-AMP binding domain) (NCBI ptt file)||38, 240|
|CAC1627||gyrB||DNA gyrase B subunit (NCBI ptt file)||105, 142|
|CAC1628||gyrA||DNA gyrase A subunit (NCBI ptt file)||2, 105|
|CAC1654||CAC1654||Zn-dependent metalloprotease, insulinase family (NCBI ptt file)||105, 281|
|CAC1688||CAC1688||Penicillin-binding protein (NCBI ptt file)||38, 316|
|CAC1732||CAC1732||Hypothetical protein (NCBI ptt file)||38, 105|
|CAC1817||CAC1817||Stage V sporulation protein, spoVS (NCBI ptt file)||38, 73|
|CAC1819||aspB||Aspartate Aminotransferase (NCBI ptt file)||38, 87|
|CAC2034||CAC2034||Hypothetical protein (NCBI ptt file)||38, 279|
|CAC2261||CAC2261||HD-hydrolase domain containing protein, YHAM B.subtilis ortholog (NCBI ptt file)||38, 278|
|CAC2270||CAC2270||Hypothetical protein (NCBI ptt file)||38, 352|
|CAC2409||CAC2409||Transglutaminase-like enzyme, putative cysteine protease (NCBI ptt file)||59, 105|
|CAC2411||CAC2411||Zn-dependent protease of MPP family (NCBI ptt file)||105, 335|
|CAC2412||CAC2412||Hypothetical protein (NCBI ptt file)||105, 279|
|CAC2413||CAC2413||Predicted membrane protein (NCBI ptt file)||105, 283|
|CAC2464||CAC2464||Hypothetical protein, CF-40 family (NCBI ptt file)||105, 163|
|CAC2470||CAC2470||Uncharacterized Zn-finger protein (NCBI ptt file)||38, 78|
|CAC2476||CAC2476||Uncharacterized protein, homolog of Spirochaeta aurantia (gi:152901) (NCBI ptt file)||38, 304|
|CAC2477||CAC2477||Hypothetical protein (NCBI ptt file)||38, 304|
|CAC2630||CAC2630||Uncharaterized conserved protein, YOME B.subtilis ortholog (NCBI ptt file)||19, 105|
|CAC2721||CAC2721||Response regulator (CheY-like reciever domain and HTH-type DNA-binding domain) (NCBI ptt file)||38, 316|
|CAC2842||CAC2842||Transcription accessory protein TEX, RNA-binding protein containing S1 domain (NCBI ptt file)||105, 310|
|CAC2888||rpmE||50S ribosomal protein L31 (NCBI ptt file)||38, 304|
|CAC3049||CAC3049||Glycosyltransferase (NCBI ptt file)||105, 311|
|CAC3206||CAC3206||Ribosomal protein S1 domain family protein (NCBI ptt file)||38, 295|
|CAC3217||spoVC||Stage V sporulation protein C, peptidyl-tRNA hydrolase (NCBI ptt file)||63, 105|
|CAC3223||spoVG||Stage V sporulation protein G (NCBI ptt file)||105, 289|
|CAC3287||CAC3287||Predicted membrane protein (NCBI ptt file)||105, 281|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
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