Organism : Clostridium acetobutylicum | Module List :
Cysteine synthase/cystathionine beta-synthase, CysK (NCBI ptt file)
Functional Annotations (5)
|Cysteine synthase||cog/ cog|
|cysteine synthase activity||go/ molecular_function|
|cysteine biosynthetic process from serine||go/ biological_process|
|pyridoxal phosphate binding||go/ molecular_function|
Regulation information for CAC2235(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC2235
Module neighborhood information for CAC2235
|Gene||Common Name||Description||Module membership|
|CAC0094||CAC0094||Ferredoxin-nitrite reductase (NCBI ptt file)||27, 276|
|CAC0102||CAC0102||O-acetylhomoserine sulfhydrylase (NCBI ptt file)||23, 37|
|CAC0103||cysC||Adenylylsulfate kinase (NCBI ptt file)||23, 37|
|CAC0104||CAC0104||Adenylylsulfate reductase, subunit A (NCBI ptt file)||23, 37|
|CAC0105||CAC0105||Ferredoxin (NCBI ptt file)||23, 37|
|CAC0106||CAC0106||ABC-type probable sulfate transporter, periplasmic binding protein (NCBI ptt file)||23, 37|
|CAC0107||CAC0107||ABC-type sulfate transporter, ATPase component (NCBI ptt file)||23, 37|
|CAC0108||CAC0108||ABC-type probable sulfate transporter, permease protein (NCBI ptt file)||23, 37|
|CAC0109||cysD||Sulfate adenylate transferase, CysD subfamily (NCBI ptt file)||23, 37|
|CAC0110||cysN||GTPase, sulfate adenylate transferase subunit 1 (NCBI ptt file)||23, 37|
|CAC0197||CAC0197||Transcriptional regulator, MarR/EmrR family (NCBI ptt file)||27, 147|
|CAC0198||CAC0198||Uncharacterized membrane protein, ortholog YYAS B.subtilis (NCBI ptt file)||27, 52|
|CAC0268||CAC0268||ABC transporter ATP-binding protein (NCBI ptt file)||27, 276|
|CAC0269||CAC0269||Uncharacterized membrane protein (NCBI ptt file)||27, 276|
|CAC0548||CAC0548||Predicted metal-dependent hydrolase (NCBI ptt file)||27, 31|
|CAC0634||CAC0634||Predicted membrane protein (NCBI ptt file)||27, 262|
|CAC0880||CAC0880||Periplasmic amino acid binding protein (NCBI ptt file)||23, 147|
|CAC0929||CAC0929||SAM-dependent methyltransferase (NCBI ptt file)||23, 37|
|CAC0930||metB||Cystathionine gamma-synthase (NCBI ptt file)||23, 37|
|CAC0931||CAC0931||Cysteine synthase (NCBI ptt file)||23, 37|
|CAC0932||CAC0932||Hypothetical protein (NCBI ptt file)||23, 321|
|CAC0986||CAC0986||Lipoprotein, attached to the cytoplasmic membrane, NLPA family (NCBI ptt file)||27, 303|
|CAC1325||CAC1325||Uncharacterized conserved protein, YitT (B.subtilis) family (NCBI ptt file)||27, 31|
|CAC1667||CAC1667||HD family hydrolase, diverged (NCBI ptt file)||27, 262|
|CAC1668||CAC1668||Transcriptional regulator, AcrR family (NCBI ptt file)||27, 262|
|CAC2235||cysK||Cysteine synthase/cystathionine beta-synthase, CysK (NCBI ptt file)||23, 27|
|CAC2260||CAC2260||Spore coat polysaccharide biosynthesis protein, Pyridoxal-dependent enzyme (NCBI ptt file)||27, 52|
|CAC2445||CAC2445||AICAR transformylase domain of PurH-like protein (NCBI ptt file)||27, 303|
|CAC2446||CAC2446||Hypothetical protein (NCBI ptt file)||27, 209|
|CAC2693||CAC2693||Predicted membrane protein (NCBI ptt file)||27, 60|
|CAC2782||CAC2782||Predicted permease (NCBI ptt file)||27, 196|
|CAC2783||cysD||O-acetylhomoserine sulfhydrylase (NCBI ptt file)||27, 196|
|CAC2917||CAC2917||acetyl esterase family enzyme (NCBI ptt file)||27, 286|
|CAC3314||CAC3314||Nitroreductase family protein (NCBI ptt file)||27, 80|
|CAC3325||CAC3325||Periplasmic amino acid binding protein (NCBI ptt file)||23, 37|
|CAC3326||CAC3326||Amino acid ABC-type transporter, permease component (NCBI ptt file)||23, 37|
|CAC3327||CAC3327||Amino acid ABC-type transporter, ATPase component (NCBI ptt file)||23, 37|
|CAC3664||CAC3664||Predicted flavodoxin (NCBI ptt file)||23, 147|
|CAC3665||CAC3665||Alpha/beta superfamily hydrolase (NCBI ptt file)||23, 167|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
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