Organism : Clostridium acetobutylicum | Module List :
Low specificity L-threonine aldolase (NCBI ptt file)
Functional Annotations (4)
|Threonine aldolase||cog/ cog|
|threonine aldolase activity||go/ molecular_function|
|cellular amino acid metabolic process||go/ biological_process|
|pyridoxal phosphate binding||go/ molecular_function|
Regulation information for CAC3420(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC3420
Module neighborhood information for CAC3420
|Gene||Common Name||Description||Module membership|
|CAC0076||CAC0076||Predicted permease (NCBI ptt file)||31, 262|
|CAC0310||abrB||Regulators of stationary/sporulation gene expression, abrB B.subtilis ortholog (NCBI ptt file)||31, 303|
|CAC0634||CAC0634||Predicted membrane protein (NCBI ptt file)||27, 262|
|CAC0646||leuS||Leucyl-tRNA synthetase (NCBI ptt file)||196, 303|
|CAC0771||CAC0771||Cobalamin biosynthesis protein CbiM (NCBI ptt file)||262, 304|
|CAC0847||CAC0847||Probable cation efflux pump (multidrug resistance protein) (NCBI ptt file)||252, 262|
|CAC0872||CAC0872||Xanthine permease (NCBI ptt file)||77, 303|
|CAC0878||CAC0878||Amino acid ABC transporter permease component (NCBI ptt file)||147, 303|
|CAC0879||CAC0879||ABC-type polar amino acid transport system, ATPase component (NCBI ptt file)||147, 303|
|CAC0889||CAC0889||Uncharacterized conserved membrane protein (NCBI ptt file)||196, 303|
|CAC0986||CAC0986||Lipoprotein, attached to the cytoplasmic membrane, NLPA family (NCBI ptt file)||27, 303|
|CAC1171||CAC1171||Hypothetical protein (NCBI ptt file)||52, 262|
|CAC1173||CAC1173||Hypothetical protein (NCBI ptt file)||52, 262|
|CAC1316||CAC1316||Predicted membrane protein (NCBI ptt file)||262, 303|
|CAC1329||CAC1329||Surfactin biosynthesis-related protein, SFP (NCBI ptt file)||196, 262|
|CAC1583||CAC1583||Predicted P-loop ATPase (NCBI ptt file)||262, 303|
|CAC1610||brnQ||Branched-chain amino acid permease (NCBI ptt file)||196, 303|
|CAC1667||CAC1667||HD family hydrolase, diverged (NCBI ptt file)||27, 262|
|CAC1668||CAC1668||Transcriptional regulator, AcrR family (NCBI ptt file)||27, 262|
|CAC1778||CAC1778||Amidase from nicotinamidase family (NCBI ptt file)||130, 303|
|CAC1825||metB||Homoserine trans-succinylase (NCBI ptt file)||260, 303|
|CAC1826||CAC1826||Hypothetical protein (NCBI ptt file)||196, 303|
|CAC1853||CAC1853||Predicted membrane protein (NCBI ptt file)||179, 262|
|CAC2445||CAC2445||AICAR transformylase domain of PurH-like protein (NCBI ptt file)||27, 303|
|CAC2738||CAC2738||Uncharacterized conserved protein (NCBI ptt file)||31, 262|
|CAC2749||CAC2749||Predicted phosphoesterase (NCBI ptt file)||167, 303|
|CAC2772||CAC2772||Permease (NCBI ptt file)||77, 262|
|CAC2841||CAC2841||Conserved membrane protein, probable transporter, YPAA B.subtilis ortholog (NCBI ptt file)||262, 266|
|CAC2943||CAC2943||N-terminal domain intergin-like repeats and c-terminal - cell wall-associated hydrolase domain (NCBI ptt file)||77, 262|
|CAC2991||metS||Methionyl-tRNA synthetase (NCBI ptt file)||196, 303|
|CAC3297||CAC3297||D-alanyl-D-alanine carboxypeptidase family hydrolase, YODJ B.subtilis ortholog (NCBI ptt file)||147, 262|
|CAC3322||CAC3322||Predicted acetyltransferase (NCBI ptt file)||252, 262|
|CAC3401||CAC3401||Predicted membrane protein (NCBI ptt file)||52, 262|
|CAC3420||CAC3420||Low specificity L-threonine aldolase (NCBI ptt file)||262, 303|
|CAC3589||CAC3589||Uncharacterized conserved membrane protein, YHGE B.subtilis ortholog (NCBI ptt file)||238, 303|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
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Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
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