Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 11 - 20 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Filter by Module number e.g "401"
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Title Gene Count Motif 1 e-value Motif 2 e-value Residual Expression TF Influences
Module_242 19
  • CD630_11970 - spoiIIIAF Type: Gene
    Product:Stage III sporulation protein AF | Pathway: | COG: Function unknown
  • CD630_01250 - spoIIQ Type: Gene
    Product:Stage II sporulation protein Q | Pathway: | COG: Cell wall/membrane/envelope biogenesis
  • CD630_05970 - cotF Type: Gene
    Product:Spore coat protein | Pathway: | COG: Function unknown
  • CD630_24420 - spoIV Type: Gene
    Product:Stage IV sporulation protein | Pathway: | COG: Function unknown
  • CD630_01240 - spoIID Type: Gene
    Product:Stage II sporulation protein D | Pathway: | COG: Cell cycle control, cell division, chromosome partitioning
  • CD630_11930 - spoIIIAB Type: Gene
    Product:Stage III sporulation protein AB | Pathway: | COG: Function unknown
  • CD630_11990 - spoIIIAH Type: Gene
    Product:Stage III sporulation protein AH | Pathway: | COG: Function unknown
  • CD630_11920 - spoIIIAA Type: Gene
    Product:Stage III sporulation protein AA | Pathway: | COG: Function unknown
  • CD630_11960 - spoIIIAE Type: Gene
    Product:Stage III sporulation protein AE | Pathway: | COG: Function unknown
  • CD630_24000 - cotJB2 Type: Gene
    Product:Spore coat peptide assembly protein CotJB 2 | Pathway: | COG: Function unknown
  • CD630_05980 - cotCB Type: Gene
    Product:Spore-coat protein CotCB; manganese catalase | Pathway: | COG: Inorganic ion transport and metabolism
  • CD630_11980 - spoIIIAG Type: Gene
    Product:Stage III sporulation protein AG | Pathway: | COG: Function unknown
  • CD630_11940 - spoIIIAC Type: Gene
    Product:Stage III sporulation protein AC | Pathway: | COG: Function unknown
  • CD630_24010 - cotD Type: Gene
    Product:Spore coat protein CotD; manganese catalase | Pathway: | COG: Inorganic ion transport and metabolism
  • CD630_01260 - spoIIID Type: Gene
    Product:Stage III sporulation protein D | Pathway: | COG: Transcription
  • CD630_05960 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_23990 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_32980 - Type: Gene
    Product:Putative ATP/GTP-binding protein | Pathway: | COG: Function unknown
  • CD630_11950 - spoIIIAD Type: Gene
    Product:Stage III sporulation protein AD | Pathway: | COG: Function unknown
0 NA 0.24 Inferelator: 1
Hypergeometric: 3

TF Influences from Inferelator

  1. CD630_34990 - spoVT Type: Gene
    Product:Stage V sporulation protein T | Pathway: | COG: Transcription

TF Influences from Hypergeometric Test

  1. CD630_12140 - spo0A Type: Gene
    Product:Stage 0 sporulation protein A | Pathway: | COG: Signal transduction mechanisms
  2. CD630_26430 - sigE Type: Gene
    Product:RNA polymerase sigma-E factor | Pathway: | COG: Transcription
  3. CD630_12300 - Type: Gene
    Product:RNA polymerase sigma-K factor SigK (Part 2) | Pathway: | COG: Transcription, Transcription
Module_193 21
  • CD630_06512 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_36360 - Type: Gene
    Product:Putative membrane protein | Pathway: | COG:
  • CD630_36361 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_06030 - Type: Gene
    Product:Fragment of putative membrane protein (C-terminalregion) | Pathway: | COG:
  • CD630_03540 - Type: Gene
    Product:Fragment of putative membrane protein (Part 1) | Pathway: | COG:
  • CD630_20141 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_32561 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_36350 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG: Function unknown
  • CD630_32471 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_29100 - Type: Gene
    Product:Putative phage protein | Pathway: | COG: Function unknown
  • CD630_34391 - Type: Gene
    Product:Putative spore-associated protein | Pathway: | COG:
  • CD630_25622 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_29140 - Type: Gene
    Product:Putative phage protein | Pathway: | COG: Function unknown
  • CD630_29071 - Type: Gene
    Product:Putative phage protein | Pathway: | COG:
  • CD630_23591 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_03901 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_29160 - Type: Gene
    Product:Putative phage major capsid protein | Pathway: | COG: Function unknown
  • CD630_29170 - Type: Gene
    Product:Putative scaffold protein | Pathway: | COG: Function unknown
  • CD630_29090 - Type: Gene
    Product:Putative phage protein | Pathway: | COG: Function unknown
  • CD630_36380 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG: Function unknown
  • CD630_31501 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
0 NA 0.25 Inferelator: 4
Hypergeometric: 2

TF Influences from Inferelator

  1. CD630_02760 - Type: Gene
    Product:Transcriptional regulator, AraC family | Pathway: | COG: Transcription
  2. CD630_12390 - Type: Gene
    Product:Transcriptional regulator, beta-lactams repressorPhage-type | Pathway: | COG: Transcription
  3. CD630_16860 - Type: Gene
    Product:Transcriptional regulator, repressor-like | Pathway: | COG: Transcription
  4. CD630_23160 - Type: Gene
    Product:Two-component response regulator | Pathway: | COG: Signal transduction mechanisms

TF Influences from Hypergeometric Test

  1. CD630_07720 - sigF Type: Gene
    Product:RNA polymerase sigma-F factor | Pathway: | COG: Transcription
  2. CD630_26430 - sigE Type: Gene
    Product:RNA polymerase sigma-E factor | Pathway: | COG: Transcription
Module_72 20
  • CD630_23540 - grdE Type: Gene
    Product:Glycine reductase complex component B subunitsalpha and beta (Selenoprotein PB alpha/beta) [Contains:Betaine reductase component B subunit beta; Betainereductase component B subunit alpha] | Pathway: | COG: Function unknown
  • CD630_01170 - Type: Gene
    Product:Putative ferredoxin/flavodoxin oxidoreductase,beta subunit | Pathway: | COG: Energy production and conversion
  • CD630_r0060 - 5s_rRNA Type: Gene
    Product: | Pathway: | COG:
  • CD630_23550 - trxA2 Type: Gene
    Product:Thioredoxin 2 (Trx2) | Pathway: | COG: Posttranslational modification, protein turnover, chaperones
  • CD630_23570 - grdX Type: Gene
    Product:Putative glycine reductase complex component | Pathway: | COG: Function unknown
  • CD630_01160 - Type: Gene
    Product:Putative ferredoxin/flavodoxin oxidoreductase,alpha subunit | Pathway: | COG: Energy production and conversion
  • CD630_01180 - Type: Gene
    Product:Putative ferredoxin/flavodoxin oxidoreductase,gamma subunit | Pathway: | COG: Energy production and conversion
  • CD630_01740 - cooS Type: Gene
    Product:Carbon monoxide dehydrogenase | Pathway: | COG: Energy production and conversion
  • CD630_01190 - glmM Type: Gene
    Product:Phosphoglucosamine mutase | Pathway: | COG: Carbohydrate transport and metabolism
  • CD630_01140 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG: Function unknown
  • CD630_01150 - Type: Gene
    Product:Putative 4Fe-4S ferredoxin, iron-sulfur bindingdomain protein, delta subunit | Pathway: | COG: Energy production and conversion
  • CD630_01760 - Type: Gene
    Product:Putative oxidoreductase, NAD/FAD binding subunit | Pathway: | COG: Inorganic ion transport and metabolism
  • CD630_01130 - buk Type: Gene
    Product:Butyrate kinase (BK) (Branched-chain carboxylicacid kinase) | Pathway: | COG: Energy production and conversion
  • CD630_01750 - Type: Gene
    Product:Putative oxidoreductase, Fe-S subunit | Pathway: | COG: Energy production and conversion
  • CD630_23520 - grdA Type: Gene
    Product:Glycine reductase complex selenoprotein A(selenocysteine) | Pathway: | COG: Energy production and conversion
  • CD630_01790 - gluD Type: Gene
    Product:NAD-specific glutamate dehydrogenase | Pathway: | COG: Amino acid transport and metabolism
  • CD630_23560 - trxB3 Type: Gene
    Product:Thioredoxin reductase 3 | Pathway: | COG: Posttranslational modification, protein turnover, chaperones
  • CD630_01120 - ptb Type: Gene
    Product:phosphate butyryltransferase | Pathway: | COG: Energy production and conversion
  • CD630_23510 - grdB Type: Gene
    Product:Glycine reductase complex component B gammasubunit (selenocysteine) | Pathway: | COG: Function unknown
6.7 NA 0.26 Inferelator: 2
Hypergeometric: 2

TF Influences from Inferelator

  1. CD630_16920 - Type: Gene
    Product:Transcriptional regulator, ArsR family | Pathway: | COG: Transcription
  2. CD630_16930 - Type: Gene
    Product:Putative dinitrogenase iron-molybdenum cofactor | Pathway: | COG: Function unknown

TF Influences from Hypergeometric Test

  1. CD630_32450 - prdR Type: Gene
    Product:Transcriptional regulator, sigma-54-dependent | Pathway: | COG: Transcription
  2. CD630_10640 - ccpA Type: Gene
    Product:Transcriptional regulator, LacI family | Pathway: | COG: Transcription
Module_392 28
  • CD630_32471 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_20431 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_20100 - ermB Type: Gene
    Product:rRNA adenine N-6-methyltransferase | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_20061 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG: Function unknown
  • CD630_20751 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_10631 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_03901 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_22242 - Type: Gene
    Product:Putative extrachromosomal origin protein | Pathway: | COG:
  • CD630_25622 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_26871 - Type: Gene
    Product:Putative spore associated protein | Pathway: | COG: Function unknown
  • CD630_23591 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_20091 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG: Function unknown
  • CD630_10630 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_34391 - Type: Gene
    Product:Putative spore-associated protein | Pathway: | COG:
  • CD630_20070 - ermB Type: Gene
    Product:rRNA adenine N-6-methyltransferase | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_10632 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_10633 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_10900 - rgbS Type: Gene
    Product:Fragment of two-component sensor histidine kinase(N-terminal region) | Pathway: | COG: Signal transduction mechanisms
  • CD630_t0670 - tRNA-Leu Type: Gene
    Product: | Pathway: | COG:
  • CD630_06512 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_06511 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_22670 - Type: Gene
    Product:Fragment of membrane protein, abortiveinfection-type protein (Part 2) | Pathway: | COG: Function unknown
  • CD630_20080 - Type: Gene
    Product:Putative hydrolase | Pathway: | COG: Cell cycle control, cell division, chromosome partitioning
  • CD630_35511 - Type: Gene
    Product:Putative membrane protein | Pathway: | COG: Function unknown
  • CD630_35512 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_31501 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_20141 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_33271 - Type: Gene
    Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf3 | Pathway: | COG:
0.00029 NA 0.26 Inferelator: 3
Hypergeometric: 1

TF Influences from Inferelator

  1. CD630_26400 - nrdR Type: Gene
    Product:Transcriptional regulator, repressor NrdR family | Pathway: | COG: Transcription
  2. CD630_26420 - sigG Type: Gene
    Product:RNA polymerase sigma-G factor | Pathway: | COG: Transcription
  3. CD630_34990 - spoVT Type: Gene
    Product:Stage V sporulation protein T | Pathway: | COG: Transcription

TF Influences from Hypergeometric Test

  1. CD630_12140 - spo0A Type: Gene
    Product:Stage 0 sporulation protein A | Pathway: | COG: Signal transduction mechanisms
Module_399 18
  • CD630_26200 - Type: Gene
    Product:Putative RNA-binding cell division protein | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_26190 - Type: Gene
    Product:Putative cell-division initiation protein DivIVA | Pathway: | COG: Cell cycle control, cell division, chromosome partitioning
  • CD630_26210 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG: Function unknown
  • CD630_01940 - groL Type: Gene
    Product:60 kDa chaperonin (Protein Cpn60) (GroELprotein) | Pathway: | COG: Posttranslational modification, protein turnover, chaperones
  • CD630_26230 - Type: Gene
    Product:Putative pyridoxal 5'-phosphate-dependent enzyme | Pathway: | COG: Nucleotide transport and metabolism
  • CD630_19390 - accB Type: Gene
    Product:Acetyl-CoA carboxylase subunit | Pathway: Lipid metabolism | COG: Lipid transport and metabolism
  • CD630_19380 - accC Type: Gene
    Product:Acetyl-CoA carboxylase subunit | Pathway: Lipid metabolism | COG: Lipid transport and metabolism
  • CD630_19370 - accD Type: Gene
    Product:Acetyl-CoA carboxylase subunit beta | Pathway: Lipid metabolism | COG: Lipid transport and metabolism
  • CD630_01930 - groS Type: Gene
    Product:10 kDa chaperonin (Protein Cpn10) (GroESprotein) | Pathway: | COG: Posttranslational modification, protein turnover, chaperones
  • CD630_34740 - atpB Type: Gene
    Product:ATP synthase subunit a | Pathway: | COG: Energy production and conversion
  • CD630_34720 - atpF Type: Gene
    Product:ATP synthase subunit b | Pathway: | COG: Energy production and conversion
  • CD630_34730 - atpE Type: Gene
    Product:ATP synthase subunit c | Pathway: | COG: Energy production and conversion
  • CD630_34760 - atpZ Type: Gene
    Product:ATP synthase transporter | Pathway: | COG: Function unknown
  • CD630_34670 - atpC Type: Gene
    Product:ATP synthase epsilon chain | Pathway: | COG: Energy production and conversion
  • CD630_26220 - sepF Type: Gene
    Product:Cell division protein SepF | Pathway: | COG: Function unknown
  • CD630_26240 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_34750 - atpI Type: Gene
    Product:ATP synthase subunit I | Pathway: | COG: Function unknown
  • CD630_19360 - accA Type: Gene
    Product:Acetyl-coenzyme A carboxylase carboxyltransferase subunit alpha | Pathway: Lipid metabolism | COG: Lipid transport and metabolism
NA NA 0.26 Inferelator: 1
Hypergeometric: 0

TF Influences from Inferelator

  1. CD630_17820 - Type: Gene
    Product:Two-component response regulator | Pathway: | COG: Signal transduction mechanisms

TF Influences from Hypergeometric Test

No TF Influences from the hypergeometric test
Module_67 16
  • CD630_32780 - Type: Gene
    Product:PTS system, mannose/fructose/sorbose IIAcomponent | Pathway: | COG: Carbohydrate transport and metabolism
  • CD630_04480 - orr Type: Gene
    Product:ornithine racemase | Pathway: | COG: Amino acid transport and metabolism
  • CD630_32790 - Type: Gene
    Product:PTS system, mannose/fructose/sorbose IIBcomponent | Pathway: | COG: Carbohydrate transport and metabolism
  • CD630_32760 - Type: Gene
    Product:PTS system, mannose/fructose/sorbose IIDcomponent | Pathway: | COG: Carbohydrate transport and metabolism
  • CD630_04490 - Type: Gene
    Product:Na+/H+ antiporter, NhaA family | Pathway: | COG: Energy production and conversion
  • CD630_04440 - ortB Type: Gene
    Product:2-amino-4-ketopentanoate thiolase beta subunit | Pathway: | COG: Function unknown
  • CD630_32750 - Type: Gene
    Product:Putative phosphosugar isomerase | Pathway: | COG: Cell wall/membrane/envelope biogenesis
  • CD630_04420 - ord Type: Gene
    Product:2,4-diaminopentanoate dehydrogenase | Pathway: | COG: Amino acid transport and metabolism
  • CD630_32770 - Type: Gene
    Product:PTS system, mannose/fructose/sorbose IICcomponent | Pathway: | COG: Carbohydrate transport and metabolism
  • CD630_31260 - bglG Type: Gene
    Product:Transcription antiterminator, PTS operonregulator | Pathway: | COG: Transcription
  • CD630_04430 - ortA Type: Gene
    Product:2-amino-4-ketopentanoate thiolase alpha subunit | Pathway: | COG: Function unknown
  • CD630_04460 - oraE Type: Gene
    Product:D-ornithine aminomutase E component | Pathway: | COG: Function unknown
  • CD630_04470 - Type: Gene
    Product:Putative reactivating factor foradenosylcobalamine-dependent D-ornithine aminomutase | Pathway: | COG: Function unknown
  • CD630_31240 - bglA Type: Gene
    Product:6-phospho-beta-glucosidase | Pathway: | COG: Carbohydrate transport and metabolism
  • CD630_04450 - oraS Type: Gene
    Product:D-ornithine aminomutase S component | Pathway: | COG: Function unknown
  • CD630_31250 - bglF Type: Gene
    Product:PTS system, beta-glucoside-specific IIABCcomponent | Pathway: | COG: Carbohydrate transport and metabolism
NA NA 0.27 Inferelator: 1
Hypergeometric: 1

TF Influences from Inferelator

  1. CD630_26430 - sigE Type: Gene
    Product:RNA polymerase sigma-E factor | Pathway: | COG: Transcription

TF Influences from Hypergeometric Test

  1. CD630_12750 - codY Type: Gene
    Product:Transcriptional regulator, GTP-sensingpleiotropic repressor | Pathway: | COG: Transcription
Module_212 15
  • CD630_00840 - rplE Type: Gene
    Product:50S ribosomal protein L5 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00760 - rplB Type: Gene
    Product:50S ribosomal protein L2 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00880 - rpsE Type: Gene
    Product:30S ribosomal protein S5 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00881 - rpmD Type: Gene
    Product:50S ribosomal protein L30 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00680 - rpsL Type: Gene
    Product:30S ribosomal protein S12 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00941 - rpmJ Type: Gene
    Product:50S ribosomal protein L36 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00690 - rpsG Type: Gene
    Product:30S ribosomal protein S7 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00990 - rplQ Type: Gene
    Product:50S ribosomal protein L17 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00850 - rpsH Type: Gene
    Product:30S ribosomal protein S8 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00960 - rpsK Type: Gene
    Product:30S ribosomal protein S11 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00841 - rpsZ Type: Gene
    Product:30S ribosomal protein S14 type Z | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00710 - tuf Type: Gene
    Product:Elongation factor EFTu/EF1A (EF-Tu) | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00970 - rpsD Type: Gene
    Product:30S ribosomal protein S4 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00800 - rplP Type: Gene
    Product:50S ribosomal protein L16 | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_00801 - rpmC Type: Gene
    Product:50S ribosomal protein L29 | Pathway: | COG: Translation, ribosomal structure and biogenesis
NA NA 0.28 Inferelator: 0
Hypergeometric: 0

TF Influences from Inferelator

No TF influences from Inferelator

TF Influences from Hypergeometric Test

No TF Influences from the hypergeometric test
Module_252 4
  • CD630_21341 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_07390 - Type: Gene
    Product:Putative exported protein | Pathway: | COG:
  • CD630_12340 - Type: Gene
    Product:Putative phage protein | Pathway: | COG:
  • CD630_18440 - Type: Gene
    Product:Fragment of conserved hypothetical protein (Part1) | Pathway: | COG: Function unknown
NA NA 0.29 Inferelator: 2
Hypergeometric: 0

TF Influences from Inferelator

  1. CD630_13810 - Type: Gene
    Product:Transcriptional regulator, TetR family | Pathway: | COG: Transcription
  2. CD630_16880 - Type: Gene
    Product:Two-component response regulator | Pathway: | COG: Signal transduction mechanisms

TF Influences from Hypergeometric Test

No TF Influences from the hypergeometric test
Module_8 19
  • CD630_34260 - cbiF Type: Gene
    Product:Cobalt-precorrin-4 C(11)-methyltransferase(Cobalt-precorrin-3 methylase) | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_34190 - hemB Type: Gene
    Product:Delta-aminolevulinic acid dehydratase(porphobilinogen synthase) | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_34340 - cobB Type: Gene
    Product:Cobyrinic acid A,C-diamide synthase | Pathway: Cofactor biosynthesis | COG: Coenzyme transport and metabolism
  • CD630_34270 - cbiT Type: Gene
    Product:Cobalt-precorrin-6Y C(15)-methyltransferase | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_34350 - cobQ Type: Gene
    Product:Cobyric acid synthase CobQ | Pathway: Cofactor biosynthesis | COG: Coenzyme transport and metabolism
  • CD630_34290 - cbiD Type: Gene
    Product:Cobalt-precorrin-6A synthase [deacetylating] | Pathway: Cofactor biosynthesis | COG: Coenzyme transport and metabolism
  • CD630_34710 - atpH Type: Gene
    Product:ATP synthase subunit delta | Pathway: | COG: Energy production and conversion
  • CD630_34230 - cbiJ Type: Gene
    Product:Cobalt-precorrin-6A reductase | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_34280 - cbiE Type: Gene
    Product:Cobalt-precorrin-6Y C(5)-methyltransferase(Cobalt-precorrin-6 methyltransferase) (Cobalt-precorrin-6Ymethylase) | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_34250 - cbiG Type: Gene
    Product:Cobalamin biosynthesis protein CbiG | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_34700 - atpA Type: Gene
    Product:ATPase subunit alpha | Pathway: | COG: Energy production and conversion
  • CD630_34240 - cbiH Type: Gene
    Product:Cobalt-precorrin-3B C(17)-methyltransferase(Cobalt-precorrin-3 methyltransferase) (Cobalt-precorrin-3methylase) | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_34210 - hemC Type: Gene
    Product:Porphobilinogen deaminase (PBG)(Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogensynthase) | Pathway: Porphyrin-containing compound metabolism | COG: Coenzyme transport and metabolism
  • CD630_34200 - cobA + hemD Type: Gene
    Product:Bifunctional uroporphyrinogen-IIImethyltransferase/uroporphyrinogen-III synthase | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_34220 - cbiK Type: Gene
    Product:Sirohydrochlorin cobaltochelatase | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_34730 - atpE Type: Gene
    Product:ATP synthase subunit c | Pathway: | COG: Energy production and conversion
  • CD630_34690 - atpG Type: Gene
    Product:ATP synthase gamma chain | Pathway: | COG: Energy production and conversion
  • CD630_34300 - cbiC Type: Gene
    Product:Cobalt-precorrin-8X methylmutase(Cobalt-precorrin isomerase) (HBA synthase) | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_34680 - atpD Type: Gene
    Product:ATP synthase subunit beta | Pathway: | COG: Energy production and conversion
NA NA 0.31 Inferelator: 2
Hypergeometric: 0

TF Influences from Inferelator

  1. CD630_11770 - fapR Type: Gene
    Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) | Pathway: | COG: Transcription
  2. CD630_17820 - Type: Gene
    Product:Two-component response regulator | Pathway: | COG: Signal transduction mechanisms

TF Influences from Hypergeometric Test

No TF Influences from the hypergeometric test
Module_303 21
  • CD630_16360 - terD Type: Gene
    Product:Tellurium resistance protein | Pathway: | COG: Signal transduction mechanisms
  • CD630_08250 - rbr Type: Gene
    Product:Rubrerythrin | Pathway: | COG: Energy production and conversion
  • CD630_21540 - Type: Gene
    Product:Putative ATP/GTP-binding protein | Pathway: | COG: Function unknown
  • CD630_24320 - glyS Type: Gene
    Product:Glycyl-tRNA synthetase beta subunit(Glycine--tRNA ligase beta subunit) (GlyRS) | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_15250 - Type: Gene
    Product:Putative iron-sulfur protein | Pathway: | COG: Energy production and conversion
  • CD630_21570 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG:
  • CD630_15240 - Type: Gene
    Product:Putative rubrerythrin | Pathway: | COG: Energy production and conversion
  • CD630_11250 - Type: Gene
    Product:Nitroreductase-family protein | Pathway: | COG: Function unknown
  • CD630_16340 - terD Type: Gene
    Product:Tellurium resistance protein | Pathway: | COG: Signal transduction mechanisms
  • CD630_21550 - bioB Type: Gene
    Product:Biotin synthase | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_25130 - Type: Gene
    Product:Putative translation inhibitor endoribonuclease | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_15260 - pyrC Type: Gene
    Product:Dihydroorotase (DHOase) | Pathway: Pyrimidine metabolism | COG: Nucleotide transport and metabolism
  • CD630_15370 - aspB Type: Gene
    Product:Putative glutamate synthase | Pathway: | COG: Amino acid transport and metabolism
  • CD630_25140 - tdcB Type: Gene
    Product:Threonine dehydratase II | Pathway: | COG: Amino acid transport and metabolism
  • CD630_15360 - Type: Gene
    Product:Ferredoxin--NADP(+) reductase subunit alpha | Pathway: | COG: Energy production and conversion
  • CD630_21560 - thiH Type: Gene
    Product:Thiamine biosynthesis protein ThiH | Pathway: | COG: Coenzyme transport and metabolism
  • CD630_08260 - Type: Gene
    Product:Putative ferric-uptake regulator | Pathway: | COG: Transcription
  • CD630_21530 - Type: Gene
    Product:Conserved hypothetical protein | Pathway: | COG: Function unknown
  • CD630_22200 - Type: Gene
    Product:Putative cyclic nucleotides-binding protein | Pathway: | COG: Signal transduction mechanisms
  • CD630_24330 - glyQ Type: Gene
    Product:Glycyl-tRNA synthetase alpha subunit(Glycine--tRNA ligase alpha subunit) (GlyRS) | Pathway: | COG: Translation, ribosomal structure and biogenesis
  • CD630_08270 - rbo Type: Gene
    Product:Rubredoxin oxidoreductase (desulfoferrodoxin) | Pathway: | COG: Energy production and conversion
0 NA 0.31 Inferelator: 3
Hypergeometric: 0

TF Influences from Inferelator

  1. CD630_08260 - Type: Gene
    Product:Putative ferric-uptake regulator | Pathway: | COG: Transcription
  2. CD630_16920 - Type: Gene
    Product:Transcriptional regulator, ArsR family | Pathway: | COG: Transcription
  3. CD630_22200 - Type: Gene
    Product:Putative cyclic nucleotides-binding protein | Pathway: | COG: Signal transduction mechanisms

TF Influences from Hypergeometric Test

No TF Influences from the hypergeometric test