Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 41 - 50 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_311	19 CD630_11500 - minD Type: Gene Product:Septum site-determining protein MinD (Celldivision inhibitor MinD) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_25900 - dapF Type: Gene Product:Diaminopimelate epimerase (DAP epimerase) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_25850 - def2 Type: Gene Product:Peptide deformylase 2 (PDF 2) (Polypeptidedeformylase 2 ) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25790 - Type: Gene Product:Putative phosphatase, 2C family \| Pathway: \| COG: Signal transduction mechanisms CD630_36550 - purA Type: Gene Product:Adenylosuccinate synthetase (IMP--aspartateligase) (AdSS) (AMPSase) \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_25760 - Type: Gene Product:Putative GTPase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25800 - Type: Gene Product:Putative radical SAM-family protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25820 - Type: Gene Product:Putative metal-dependent peptidase \| Pathway: \| COG: Function unknown CD630_11460 - mreC Type: Gene Product:Rod shape-determining protein MreC \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_25890 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25750 - rpe Type: Gene Product:Ribulose-phosphate 3-epimerase(Pentose-5-phosphate 3-epimerase) (PPE) (R5P3E) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02190 - purC Type: Gene Product:Phosphoribosylaminoimidazole-succinocarboxamidesynthase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_25880 - gmk Type: Gene Product:Guanylate kinase (GMP kinase) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_36560 - Type: Gene Product:Conserved hypothetical protein with a TonB box \| Pathway: \| COG: CD630_25770 - fabG Type: Gene Product:3-oxoacyl-[acyl-carrier-protein] reductase(3-ketoacyl- acyl carrier protein reductase) \| Pathway: \| COG: Function unknown CD630_25780 - Type: Gene Product:Putative serine/threonine-protein kinase andphosphatase \| Pathway: \| COG: Signal transduction mechanisms CD630_25840 - fmt Type: Gene Product:Methionyl-tRNA formyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_02180 - purE Type: Gene Product:Phosphoribosylaminoimidazole carboxylasecatalytic subunit \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_25870 - coaBC Type: Gene Product:Coenzyme A biosynthesis bifunctional proteinCoaBC; phosphopantothenoylcysteinesynthetase/decarboxylase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism	`NA`	`NA`	0.37	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_183	17 CD630_30470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30460 - murQ Type: Gene Product:N-acetylmuramic acid 6-phosphate etherase \| Pathway: Amino-sugar metabolism \| COG: Carbohydrate transport and metabolism CD630_07870 - Type: Gene Product:Putative metal-binding protein \| Pathway: \| COG: Function unknown CD630_07890 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30480 - Type: Gene Product:PTS system, lactose/cellobiose-family IICmembrane component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_07900 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_07880 - Type: Gene Product:Putative GTP-binding protein, HflX type \| Pathway: \| COG: Function unknown CD630_13020 - Type: Gene Product:Putative MazG-like pyrophosphohydrolase \| Pathway: \| COG: Function unknown CD630_30490 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBsubunit \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13030 - npdA Type: Gene Product:NAD-dependent deacetylase, Sir2 family \| Pathway: \| COG: Transcription CD630_14380 - Type: Gene Product:Putative TPR repeat-containing protein \| Pathway: \| COG: Function unknown CD630_23050 - pilW Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: Function unknown CD630_16230 - Type: Gene Product:NADH-oxygen oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_22150 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_15220 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_13040 - acd Type: Gene Product:Mannosyl-glycoproteinendo-beta-N-acetylglucosamidase \| Pathway: \| COG: Carbohydrate transport and metabolism	0.0000000004	0.0000012	0.37	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_19310 - lexA Type: Gene Product:Transcriptional regulator, LexA repressor \| Pathway: \| COG: Transcription CD630_35440 - Type: Gene Product:Transcriptional regulator, AsnC/Lrp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_184	21 CD630_02480 - fliF Type: Gene Product:Flagellar M-ring protein FliF \| Pathway: \| COG: Cell motility CD630_02620 - flhB Type: Gene Product:Bifunctional flagellar biosynthesis proteinFliR/FlhB \| Pathway: \| COG: Cell motility CD630_02630 - flhA Type: Gene Product:Flagellar biosynthesis protein FlhA \| Pathway: \| COG: Cell motility CD630_02490 - fliG Type: Gene Product:Flagellar motor switch protein FliG \| Pathway: \| COG: Cell motility CD630_02640 - flhF Type: Gene Product:Flagellar biosynthesis regulator FlhF(Flagella-associated GTP-binding protein) \| Pathway: \| COG: Cell motility CD630_02510 - fliI Type: Gene Product:ATP synthase subunit beta FliI \| Pathway: \| COG: Cell motility, Intracellular trafficking, secretion, and vesicular transport CD630_02650 - flhG Type: Gene Product:Flagellar number regulator FlhG \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_02470 - fliE Type: Gene Product:Flagellar hook-basal body complex protein FliE \| Pathway: \| COG: Cell motility CD630_02600 - fliP Type: Gene Product:Flagellar biosynthesis protein FliP \| Pathway: \| COG: Cell motility CD630_02551 - FlbD Type: Gene Product:Flagellar protein FlbD \| Pathway: \| COG: Cell motility CD630_02530 - fliK Type: Gene Product:Flagellar hook-length control protein FliK \| Pathway: \| COG: Cell motility CD630_02460 - flgC Type: Gene Product:Flagellar basal-body rod protein FlgC \| Pathway: \| COG: Cell motility CD630_02520 - fliJ Type: Gene Product:Flagellar protein FliJ \| Pathway: \| COG: Cell motility CD630_02570 - motB Type: Gene Product:Flagellar motor rotation protein MotB (Chemotaxisprotein MotB) \| Pathway: \| COG: Cell motility CD630_02670 - Type: Gene Product:Putative flagellar protein \| Pathway: \| COG: CD630_02560 - motA Type: Gene Product:Flagellar motor rotation protein MotA \| Pathway: \| COG: Cell motility CD630_02540 - flgD Type: Gene Product:Basal-body rod modification protein FlgD \| Pathway: \| COG: Cell motility CD630_02450 - flgB Type: Gene Product:Flagellar basal-body rod protein FlgB \| Pathway: \| COG: Cell motility CD630_02580 - fliL Type: Gene Product:Flagellar basal body-associated protein FliL \| Pathway: \| COG: Cell motility CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription CD630_02610 - fliQ Type: Gene Product:Flagellar biosynthetic protein FliQ \| Pathway: \| COG: Cell motility	`NA`	`NA`	0.37	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription
Module_162	20 CD630_09430 - Type: Gene Product:Putative phage DNA-binding protein \| Pathway: \| COG: Function unknown CD630_36260 - Type: Gene Product:Putative 4-hydroxy-2-oxoglutarate aldolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_36300 - Type: Gene Product:PTS system, fructose/mannitol-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28970 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36310 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_29020 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36290 - Type: Gene Product:PTS system, fructose/mannitol-family IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28960 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36430 - Type: Gene Product:Dihydroorotase \| Pathway: \| COG: Function unknown CD630_36420 - Type: Gene Product:Putative selenocysteine synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_09440 - Type: Gene Product:Putative phage terminase, large subunit \| Pathway: \| COG: Replication, recombination and repair CD630_29070 - Type: Gene Product:Putative phage lipoprotein \| Pathway: \| COG: Function unknown CD630_28990 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36280 - Type: Gene Product:Putative phosphosugar isomerase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_09450 - Type: Gene Product:Putative phage portal protein \| Pathway: \| COG: Function unknown CD630_36440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36270 - dapA4 Type: Gene Product:Dihydrodipicolinate synthase 4 (DHDPS) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_29000 - Type: Gene Product:Putative phage tail protein \| Pathway: \| COG: Function unknown CD630_29060 - Type: Gene Product:Putative phage protein \| Pathway: \| COG:	0.02	`NA`	0.37	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_36390 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_118	24 CD630_17640 - Type: Gene Product:Putative phenylalanyl-tRNA synthetase beta chain \| Pathway: \| COG: Function unknown CD630_17700 - ogt2 Type: Gene Product:Methylated-DNA-[protein]-cysteineS-methyltransferase 2 \| Pathway: \| COG: Replication, recombination and repair CD630_10620 - acpP Type: Gene Product:Acyl carrier protein (ACP) \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_15970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27910 - cwp2 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_23690 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25490 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24560 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17630 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_14030 - Type: Gene Product:Putative synthetase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_14010 - Type: Gene Product:Putative isochorismatase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_17710 - Type: Gene Product:Putative monooxygenase \| Pathway: \| COG: Function unknown CD630_27980 - cwp9 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_25470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17650 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_10630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10631 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_27900 - Type: Gene Product:Putative LmbE-like deacetylase \| Pathway: \| COG: Function unknown CD630_10840 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease protein \| Pathway: \| COG: Defense mechanisms CD630_32800 - Type: Gene Product:Sigma-54 dpendent regulator, PTS fructose family \| Pathway: \| COG: Signal transduction mechanisms CD630_24570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_25480 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_27890 - cwp66 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_25500 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism	0.00000000000023	0.06	0.37	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_10	29 CD630_11570 - norV Type: Gene Product:Anaerobic nitric oxide reductase flavorubredoxin(FlRd) (FlavoRb) \| Pathway: \| COG: Energy production and conversion CD630_00260 - clpC Type: Gene Product:class III stress response-related ATPase, AAA+superfamily \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_15240 - Type: Gene Product:Putative rubrerythrin \| Pathway: \| COG: Energy production and conversion CD630_16230 - Type: Gene Product:NADH-oxygen oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_00240 - mcsA Type: Gene Product:Activator of protein kinase McsB \| Pathway: \| COG: Function unknown CD630_03940 - ldhA Type: Gene Product:D-lactate dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_21660 - msrAB Type: Gene Product:Peptide methionine sulfoxide reductase MsrA/MsrB \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23550 - trxA2 Type: Gene Product:Thioredoxin 2 (Trx2) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23570 - grdX Type: Gene Product:Putative glycine reductase complex component \| Pathway: \| COG: Function unknown CD630_14740 - Type: Gene Product:Putative rubrerythrin (Rr) \| Pathway: \| COG: Energy production and conversion CD630_15680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_32740 - feoB Type: Gene Product:Ferrous iron transport protein B \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33100 - Type: Gene Product:Putative D-isomer specific 2-hydroxyaciddehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism, Coenzyme transport and metabolism CD630_15260 - pyrC Type: Gene Product:Dihydroorotase (DHOase) \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_05600 - nfo Type: Gene Product:Endonuclease IV \| Pathway: \| COG: Replication, recombination and repair CD630_16900 - trxA Type: Gene Product:Thioredoxin \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_00230 - ctsR Type: Gene Product:Transcriptional regulator, CtsR family \| Pathway: \| COG: Transcription CD630_23520 - grdA Type: Gene Product:Glycine reductase complex selenoprotein A(selenocysteine) \| Pathway: \| COG: Energy production and conversion CD630_23560 - trxB3 Type: Gene Product:Thioredoxin reductase 3 \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_00250 - mcsB Type: Gene Product:Tyrosine kinase protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_11250 - Type: Gene Product:Nitroreductase-family protein \| Pathway: \| COG: Function unknown CD630_23540 - grdE Type: Gene Product:Glycine reductase complex component B subunitsalpha and beta (Selenoprotein PB alpha/beta) [Contains:Betaine reductase component B subunit beta; Betainereductase component B subunit alpha] \| Pathway: \| COG: Function unknown CD630_32730 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15250 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_15350 - sseA Type: Gene Product:3-mercaptopyruvate sulfurtransferase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16910 - trxB Type: Gene Product:Putative thioredoxin-disulfide reductase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	0.0000036	`NA`	0.37	Inferelator: 1 Hypergeometric: 2 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_42	18 CD630_03850 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn916-like, CTn1-Orf30 \| Pathway: \| COG: Function unknown CD630_03851 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03840 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn916-like, CTn1-Orf29 \| Pathway: \| COG: Function unknown CD630_03860 - Type: Gene Product:Putative cell surface protein \| Pathway: \| COG: Function unknown CD630_03600 - Type: Gene Product:Transcriptional regulator, GntR family,Tn916-like, CTn1-Orf5 \| Pathway: \| COG: Transcription CD630_33920 - Type: Gene Product:Putative cell surface protein \| Pathway: \| COG: Function unknown CD630_33790 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf15 \| Pathway: \| COG: Function unknown CD630_33890 - Type: Gene Product:Putative cell-division FtsK/SpoIIIE-familyprotein Tn916-like, CTn7-Orf28 \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_03630 - Type: Gene Product:ABC-type transport system, permease Tn916-like,CTn1-Orf8 \| Pathway: \| COG: Defense mechanisms CD630_03610 - Type: Gene Product:Two-component sensor histidine kinase Tn916-like,CTn1-Orf6 \| Pathway: \| COG: Signal transduction mechanisms CD630_03620 - Type: Gene Product:Two-component response regulator Tn916-like,CTn1-Orf7 \| Pathway: \| COG: Signal transduction mechanisms CD630_33800 - Type: Gene Product:Putative cell wall hydrolase Tn916-like,CTn7-Orf16 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_03820 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf27 \| Pathway: \| COG: CD630_03640 - Type: Gene Product:ABC-type transport system, ATP-binding proteinTn916-like, CTn1-Orf9 \| Pathway: \| COG: Defense mechanisms CD630_03830 - Type: Gene Product:Putative cell-division FtsK/SpoIIIE-familyprotein Tn916-like, CTn1-Orf28 \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_33900 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn196-like, CTn7-Orf29 \| Pathway: \| COG: Function unknown CD630_33840 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf20 \| Pathway: \| COG: Function unknown CD630_33830 - Type: Gene Product:Putative ATPase Tn916-like, CTn7-Orf19 \| Pathway: \| COG: Function unknown	0.000028	0.11	0.38	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_20920 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_109	26 CD630_19070 - eutG Type: Gene Product:Ethanolamine iron-dependent Alcoholdehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_01100 - Type: Gene Product:Conserved hypothetical protein, CHP00159 family \| Pathway: \| COG: Function unknown CD630_12110 - Type: Gene Product:Putative N-acetyltransferase \| Pathway: \| COG: Transcription CD630_12130 - spoIVB Type: Gene Product:Stage IV sporulation protein B, peptidase S55family \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_13560 - Type: Gene Product:Putative CBS domain-containing protein \| Pathway: \| COG: Function unknown CD630_23860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_23840 - Type: Gene Product:Putative diguanylate cyclase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_24560 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_09970 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_25390 - rnz Type: Gene Product:Ribonuclease Z (RNase Z) (tRNase Z) (tRNA 3endonuclease) \| Pathway: \| COG: Function unknown CD630_22020 - Type: Gene Product:Putative Na+/solute symporter, SSS family \| Pathway: \| COG: Amino acid transport and metabolism CD630_19450 - Type: Gene Product:Putative enzyme \| Pathway: \| COG: Amino acid transport and metabolism CD630_12120 - bltD Type: Gene Product:Diamine N-acetyltransferase \| Pathway: \| COG: Transcription CD630_27510 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms CD630_23850 - Type: Gene Product:Putative diguanylate cyclase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_01110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23830 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_23780 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_19920 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_24570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_25380 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_11560 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19460 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_22030 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription	0.0000000023	0.03	0.39	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_110	20 CD630_33682 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19900 - Type: Gene Product:Putative protein with SH3 domain \| Pathway: \| COG: Function unknown CD630_19903 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10521 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_26930 - Type: Gene Product:Sodium:dicarboxylate symporter family protein \| Pathway: \| COG: Energy production and conversion CD630_30550 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_05770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_11730 - Type: Gene Product:Putative FAD-linked oxidase \| Pathway: \| COG: Energy production and conversion CD630_30560 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_25150 - Type: Gene Product:Putative L-aspartate-beta-decarboxylase \| Pathway: \| COG: Amino acid transport and metabolism CD630_11700 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_11720 - etfA Type: Gene Product:Electron transfer flavoprotein subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_28300 - zmp1 Type: Gene Product:Extracellular Zinc metalloprotease \| Pathway: \| COG: Function unknown CD630_11350 - Type: Gene Product:Putative SH3-domain protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27970 - Type: Gene Product:Putative calcium-binding adhesion protein \| Pathway: \| COG: Function unknown CD630_31570 - smpB Type: Gene Product:SsrA-binding protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_11340 - gloA Type: Gene Product:Lactoylglutathione lyase \| Pathway: \| COG: Amino acid transport and metabolism CD630_25160 - ansB Type: Gene Product:L-asparaginase \| Pathway: \| COG: Amino acid transport and metabolism CD630_14240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_23090 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	6.70003e-41	1.6e-25	0.39	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_65	25 CD630_24710 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_04040 - Type: Gene Product:Conserved hypothetical protein, DUF1904 family \| Pathway: \| COG: Function unknown CD630_27200 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Function unknown CD630_20290 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_32180 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30220 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_16160 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_05170 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_24720 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Function unknown CD630_35950 - Type: Gene Product:Aminopeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_04050 - rluA Type: Gene Product:Ribosomal small subunit pseudouridine synthase A \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_13910 - Type: Gene Product:Putative hydrolase, CocE/NonD family \| Pathway: \| COG: Function unknown CD630_05180 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_04220 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf17 \| Pathway: \| COG: Function unknown CD630_28440 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_23080 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_35180 - murC Type: Gene Product:UDP-N-acetylmuramate--L-alanine ligase(UDP-N-acetylmuramoyl-L-alanine synthetase) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_22560 - Type: Gene Product:Putative PTS system, EIIC component \| Pathway: \| COG: Function unknown CD630_01210 - Type: Gene Product:Putative thiosulfate sulfurtransferase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01560 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_31870 - tdcF Type: Gene Product:Putative regulatory endoribonuclease \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_23070 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_13770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_04770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32220 - sdaB Type: Gene Product:L-serine dehydratase \| Pathway: \| COG: Amino acid transport and metabolism	0.00000000000036	0.0000005	0.39	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_26030 - cdtR Type: Gene Product:Clostridium difficile binary toxin regulatorygene, LytTR family \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`