Organism : Campylobacter jejuni | Module List :
Regulation information for Cj1129c(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for Cj1129c
Module neighborhood information for Cj1129c
|Gene||Common Name||Description||Module membership|
|Cj0015c||Cj0015c||hypothetical protein Cj0015c (NCBI ptt file)||39, 62|
|Cj0023||purB||adenylosuccinate lyase (NCBI ptt file)||62, 146|
|Cj0024||nrdA||ribonucleoside-diphosphate reductase alpha chain (NCBI ptt file)||41, 62|
|Cj0029||ansA||cytoplasmic L-asparaginase (NCBI ptt file)||38, 113|
|Cj0131||Cj0131||putative periplasmic protein (NCBI ptt file)||49, 62|
|Cj0136||infB||translation initiation factor IF-2 (NCBI ptt file)||38, 125|
|Cj0149c||hom||homoserine dehydrogenase (NCBI ptt file)||62, 165|
|Cj0163c||Cj0163c||hypothetical protein Cj0163c (NCBI ptt file)||38, 41|
|Cj0299||Cj0299||putative periplasmic beta-lactamase (NCBI ptt file)||19, 62|
|Cj0319||fliG||flagellar motor switch protein (NCBI ptt file)||62, 156|
|Cj0431||Cj0431||putative periplasmic ATP /GTP-binding protein (NCBI ptt file)||57, 62|
|Cj0456c||Cj0456c||hypothetical protein Cj0456c (NCBI ptt file)||38, 78|
|Cj0546||Cj0546||hypothetical protein Cj0546 (NCBI ptt file)||23, 62|
|Cj0590||Cj0590||hypothetical protein Cj0590 (NCBI ptt file)||27, 38|
|Cj0693c||Cj0693c||hypothetical protein Cj0693c (NCBI ptt file)||15, 62|
|Cj0706||Cj0706||hypothetical protein Cj0706 (NCBI ptt file)||62, 102|
|Cj0766c||tmk||putative thymidylate kinase (NCBI ptt file)||39, 62|
|Cj0828c||ilvA||threonine dehydratase biosynthetic (NCBI ptt file)||54, 62|
|Cj0861c||pabA||para-aminobenzoate synthase glutamine amidotransferase component II (NCBI ptt file)||38, 152|
|Cj0916c||Cj0916c||hypothetical protein Cj0916c (NCBI ptt file)||38, 50|
|Cj0974||Cj0974||very hypothetical protein Cj0974 (NCBI ptt file)||29, 62|
|Cj1001||rpoD||RNA polymerase sigma factor (sigma-70) (NCBI ptt file)||53, 62|
|Cj1034c||Cj1034c||possible dnaJ-like protein (NCBI ptt file)||62, 67|
|Cj1103||csrA||carbon storage regulator homolog (NCBI ptt file)||38, 57|
|Cj1129c||wlaC||putative glycosyltransferase (NCBI ptt file)||38, 62|
|Cj1130c||wlaB||ABC-type transport protein (NCBI ptt file)||62, 141|
|Cj1149c||gmhA||phosphoheptose isomerase (NCBI ptt file)||34, 38|
|Cj1150c||waaE||putative ADP-heptose synthase (NCBI ptt file)||34, 38|
|Cj1152c||Cj1152c||putative phosphatase (NCBI ptt file)||34, 38|
|Cj1180c||Cj1180c||putative ABC transporter ATP binding protein (NCBI ptt file)||26, 62|
|Cj1203c||Cj1203c||putative integral membrane protein (NCBI ptt file)||38, 41|
|Cj1215||Cj1215||putative periplasmic protein (NCBI ptt file)||62, 147|
|Cj1223c||Cj1223c||putative two-component regulator (NCBI ptt file)||38, 41|
|Cj1258||Cj1258||possible phosphotyrosine protein phosphatase (NCBI ptt file)||38, 81|
|Cj1312||Cj1312||possible flagellar protein (NCBI ptt file)||38, 81|
|Cj1371||Cj1371||putative periplasmic protein (vacJ homolog) (NCBI ptt file)||48, 62|
|Cj1471c||Cj1471c||putative type II protein secretion system E protein (NCBI ptt file)||62, 155|
|Cj1492c||Cj1492c||putative two-component sensor (NCBI ptt file)||38, 60|
|Cj1643||Cj1643||putative periplasmic protein (NCBI ptt file)||62, 141|
|Cj1673c||recA||recA protein (NCBI ptt file)||38, 110|
|Cj1720||Cj1720||hypothetical protein Cj1720 (NCBI ptt file)||38, 71|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
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