Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU0637

hypothetical protein DVU0637

CircVis
Functional Annotations (3)
Function System
Uncharacterized FAD-dependent dehydrogenases cog/ cog
thiamine biosynthetic process go/ biological_process
oxidoreductase activity go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU0637
(Mouseover regulator name to see its description)

DVU0637 is regulated by 16 influences and regulates 0 modules.
Regulators for DVU0637 (16)
Regulator Module Operator
DVU0269 103 tf
DVU1517 103 tf
DVU2567
DVU2675
103 combiner
DVU2802
DVU0110
103 combiner
DVU2802
DVU3229
103 combiner
DVU2909
DVU1628
103 combiner
DVU3111
DVU0309
103 combiner
DVUA0100 103 tf
DVU0629 30 tf
DVU1156
DVU0629
30 combiner
DVU1518 30 tf
DVU1561
DVU0629
30 combiner
DVU1949 30 tf
DVU2275
DVU1730
30 combiner
DVU2423
DVU2275
30 combiner
DVU3167 30 tf

Warning: DVU0637 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
59 1.90e-04 CCTG.acaa.cAGggaG.GgaCtT
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RegPredict
60 6.70e+00 aTCtaCCatCTTCaCaTTct
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RegPredict
199 3.50e+02 gTGCc.CacCacgatacGAC
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RegPredict
200 9.70e+02 gcgCAgcCTcaCac.aca
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU0637

DVU0637 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
Uncharacterized FAD-dependent dehydrogenases cog/ cog
thiamine biosynthetic process go/ biological_process
oxidoreductase activity go/ molecular_function
Module neighborhood information for DVU0637

DVU0637 has total of 40 gene neighbors in modules 30, 103
Gene neighbors (40)
Gene Common Name Description Module membership
DVU0036 hypothetical protein DVU0036 5, 103
DVU0052 era GTP-binding protein Era 5, 30
DVU0176 glycerophosphoryl diester phosphodiesterase family protein 30, 316
DVU0344 methyl-accepting chemotaxis protein 81, 103
DVU0567 TerC family protein 103, 116
DVU0637 hypothetical protein DVU0637 30, 103
DVU0645 methyl-accepting chemotaxis protein 103, 331
DVU0730 hypothetical protein DVU0730 30, 315
DVU0885 amidohydrolase family protein 30, 113
DVU0911 truA tRNA pseudouridine synthase A 30, 174
DVU0930 proB gamma-glutamyl kinase 30, 133
DVU0931 thiD phosphomethylpyrimidine kinase 30, 306
DVU1009 hypothetical protein DVU1009 5, 30
DVU1178 hypothetical protein DVU1178 30, 157
DVU1332 selD selenide, water dikinase, selenocysteine-containing 30, 94
DVU1362 hypothetical protein DVU1362 30, 277
DVU1363 rfbD dTDP-4-dehydrorhamnose reductase 30, 277
DVU1364 rfbB dTDP-glucose 4,6-dehydratase 30, 277
DVU1365 heme-binding protein 30, 317
DVU1366 lipoprotein 30, 277
DVU1850 CBS domain-containing protein 16, 30
DVU1950 indolepyruvate ferredoxin oxidoreductase subunit beta 30, 113
DVU2052 glycosyl transferase group 2 family protein 30, 54
DVU2053 hypothetical protein DVU2053 30, 258
DVU2054 hypothetical protein DVU2054 30, 113
DVU2055 metG methionyl-tRNA synthetase 30, 223
DVU2211 hypothetical protein DVU2211 103, 184
DVU2464 hypothetical protein DVU2464 23, 30
DVU2889 BioY family protein 30, 316
DVU2896 hypothetical protein 30, 112
DVU2938 hypothetical protein DVU2938 27, 30
DVU2971 glycosyl transferase family protein 103, 254
DVU2979 phosphatidylserine decarboxylase 103, 166
DVU2981 leuA 2-isopropylmalate synthase 46, 103
DVU2982 3-isopropylmalate dehydratase large subunit 46, 103
DVU2983 leuD 3-isopropylmalate dehydratase small subunit 46, 103
DVU2984 hypothetical protein DVU2984 46, 103
DVU2985 leuB 3-isopropylmalate dehydrogenase 46, 103
DVU3383 hypothetical protein DVU3383 103, 127
DVU3385 hypothetical protein DVU3385 31, 103
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU0637
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend