Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU2515

HD domain-containing protein

CircVis
Functional Annotations (1)
Function System
catalytic activity go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU2515
(Mouseover regulator name to see its description)

DVU2515 is regulated by 22 influences and regulates 0 modules.
Regulators for DVU2515 (22)
Regulator Module Operator
DVU0230 301 tf
DVU0653 301 tf
DVU0653
DVU2251
301 combiner
DVU1754 301 tf
DVU1754
DVU2086
301 combiner
DVU2036
DVU2097
301 combiner
DVU2836
DVU0653
301 combiner
DVU3167 301 tf
DVU3167
DVU0569
301 combiner
DVU3167
DVU2251
301 combiner
DVU0529
DVU0525
268 combiner
DVU0946 268 tf
DVU1572
DVU3255
268 combiner
DVU2114 268 tf
DVU2557
DVU0946
268 combiner
DVU2557
DVU3255
268 combiner
DVU2909
DVU0230
268 combiner
DVU3255 268 tf
DVU3255
DVU0653
268 combiner
DVU3255
DVU1584
268 combiner
DVU3255
DVU2675
268 combiner
DVUA0143 268 tf

Warning: DVU2515 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
511 8.40e+02 aacatcttaac.ag...a.aCAA
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RegPredict
512 1.70e+04 ATCtTTccG
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RegPredict
577 4.60e-01 AGaCTTCtaCataATATcTaGa
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RegPredict
578 4.70e+00 CataGATGAAG
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU2515

DVU2515 is enriched for 1 functions in 2 categories.
Enrichment Table (1)
Function System
catalytic activity go/ molecular_function
Module neighborhood information for DVU2515

DVU2515 has total of 36 gene neighbors in modules 268, 301
Gene neighbors (36)
Gene Common Name Description Module membership
DVU0128 hypothetical protein DVU0128 48, 268
DVU0299 anaerobic ribonucleoside triphosphate reductase 135, 268
DVU0300 radical SAM domain-containing protein 135, 268
DVU0613 hypothetical protein DVU0613 32, 268
DVU0722 response regulator 268, 272
DVU0891 class I/II aminotransferase 128, 301
DVU1361 lpxB lipid A disaccharide synthase 187, 268
DVU1428 pgm phosphoglucomutase 268, 318
DVU1458 chemotaxis protein CheZ 48, 268
DVU1548 OmpP1/FadL/TodX family outer membrane transporter 135, 268
DVU1590 radA DNA repair protein RadA 48, 268
DVU2140 tmk thymidylate kinase 117, 268
DVU2243 glgB glycogen branching enzyme 48, 268
DVU2288 hydrogenase subunit CooL 207, 301
DVU2416 hypothetical protein DVU2416 229, 268
DVU2417 SlyX protein 268, 308
DVU2484 cytochrome c family protein 48, 268
DVU2485 hypothetical protein DVU2485 48, 268
DVU2499 ftsZ cell division protein FtsZ 128, 301
DVU2500 ftsA cell division protein FtsA 128, 301
DVU2501 cell division protein FtsQ 128, 301
DVU2503 murC UDP-N-acetylmuramate--L-alanine ligase 128, 301
DVU2504 murG undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 128, 301
DVU2505 cell cycle protein FtsW 128, 301
DVU2506 murD UDP-N-acetylmuramoylalanine--D-glutamate ligase 128, 301
DVU2507 mraY phospho-N-acetylmuramoyl-pentapeptide-transferase 128, 301
DVU2508 murF UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 249, 301
DVU2509 murE UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase 249, 301
DVU2511 hypothetical protein DVU2511 128, 301
DVU2512 mraW S-adenosyl-methyltransferase MraW 128, 301
DVU2513 mraZ cell division protein MraZ 128, 301
DVU2515 HD domain-containing protein 268, 301
DVU2673 anaerobic glycerol-3-phosphate dehydrogenase subunit A, truncation 14, 268
DVU2762 hypothetical protein DVU2762 48, 268
DVU3355 SPFH domain-containing protein/band 7 family protein 60, 268
DVU3356 NAD-dependent epimerase/dehydratase family protein 268, 303
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU2515
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend