Organism : Geobacter sulfurreducens | Module List :
methyl-accepting chemotaxis protein, putative (VIMSS)
Functional Annotations (5)
|Methyl-accepting chemotaxis protein||cog/ cog|
|signal transducer activity||go/ molecular_function|
|signal transduction||go/ biological_process|
Regulation information for GSU2372(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for GSU2372
Module neighborhood information for GSU2372
|Gene||Common Name||Description||Module membership|
|GSU0123||GSU0123||nickel-dependent hydrogenase, small subunit (VIMSS)||96, 252|
|GSU0198||GSU0198||conserved hypothetical protein (VIMSS)||220, 310|
|GSU0208||GSU0208||hypothetical protein (VIMSS)||109, 220|
|GSU0294||GSU0294||HD domain protein (NCBI)||220, 304|
|GSU0373||GSU0373||sensor histidine kinase (VIMSS)||96, 220|
|GSU0396||GSU0396||conserved hypothetical protein (VIMSS)||96, 229|
|GSU0427||GSU0427||lipoprotein, putative (VIMSS)||96, 278|
|GSU0431||GSU0431||conserved hypothetical protein (VIMSS)||96, 130|
|GSU0432||GSU0432||conserved hypothetical protein (VIMSS)||96, 278|
|GSU0433||GSU0433||clpB protein, putative (NCBI)||21, 96|
|GSU0449||GSU0449||hypothetical protein (VIMSS)||96, 137|
|GSU0518||GSU0518||sodium/solute symporter family protein (VIMSS)||118, 220|
|GSU0574||GSU0574||membrane protein, putative (VIMSS)||96, 186|
|GSU0801||GSU0801||hypothetical protein (VIMSS)||96, 109|
|GSU0896||tldD||tldD protein (NCBI)||86, 220|
|GSU1064||GSU1064||hypothetical protein (VIMSS)||14, 220|
|GSU1095||phoU||phosphate transport system regulatory protein PhoU (NCBI)||1, 96|
|GSU1146||GSU1146||conserved domain protein (NCBI)||96, 109|
|GSU1538||GSU1538||methylamine utilization protein MauG, putative (VIMSS)||151, 220|
|GSU1550||GSU1550||4-oxalocrotonate tautomerase family protein (VIMSS)||220, 304|
|GSU1552||GSU1552||conserved hypothetical protein (VIMSS)||220, 287|
|GSU1553||GSU1553||conserved hypothetical protein (VIMSS)||99, 220|
|GSU1554||GSU1554||GGDEF domain protein (NCBI)||165, 220|
|GSU1676||GSU1676||hypothetical protein (VIMSS)||96, 236|
|GSU1988||GSU1988||hypothetical protein (VIMSS)||96, 206|
|GSU2169||GSU2169||hypothetical protein (VIMSS)||96, 174|
|GSU2309||GSU2309||metallo-beta-lactamase family protein (VIMSS)||96, 130|
|GSU2318||mma4||cyclopropane-fatty-acyl-phospholipid synthase, putative (NCBI)||118, 220|
|GSU2345||GSU2345||rsbU-related protein (VIMSS)||220, 317|
|GSU2372||GSU2372||methyl-accepting chemotaxis protein, putative (VIMSS)||96, 220|
|GSU2476||GSU2476||TPR domain protein (VIMSS)||46, 220|
|GSU2480||kdpA||potassium-transporting ATPase, A subunit (NCBI)||96, 252|
|GSU2481||kdpB||potassium-transporting ATPase, B subunit (NCBI)||96, 257|
|GSU2484||kdpE||DNA-binding response regulator KdpE (NCBI)||96, 257|
|GSU2487||arcC||carbamate kinase (NCBI)||178, 220|
|GSU2534||GSU2534||sensory box/response regulator (VIMSS)||96, 266|
|GSU2576||GSU2576||HD domain protein (NCBI)||63, 220|
|GSU2711||GSU2711||hypothetical protein (VIMSS)||6, 220|
|GSU2975||GSU2975||inorganic pyrophosphatase, manganese-dependent, putative (VIMSS)||46, 220|
|GSU2984||znuC||permease component of zinc ABC transporter (Dmitry Rodionov)||96, 287|
|GSU3019||GSU3019||dehydrogenase, E1 component, alpha and beta subunits (NCBI)||27, 96|
|GSU3239||cafA||ribonuclease G (NCBI)||96, 236|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
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