Organism : Halobacterium salinarum NRC-1 | Module List :
VNG1510C

hypothetical protein VNG1510C

CircVis
Functional Annotations (6)
Function System
Histone acetyltransferase cog/ cog
histone acetyltransferase activity go/ molecular_function
N-acetyltransferase activity go/ molecular_function
metabolic process go/ biological_process
iron-sulfur cluster binding go/ molecular_function
ELP3 tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for VNG1510C
(Mouseover regulator name to see its description)

VNG1510C is regulated by 7 influences and regulates 61 modules.
Regulators for VNG1510C (7)
Regulator Module Operator
VNG0247C 265 tf
VNG1179C 265 tf
VNG1215G
VNG1548C
265 combiner
VNG1237C 265 tf
VNG2112C 265 tf
VNG5068G
VNG1886C
265 combiner
VNG6287H 265 tf

Warning: VNG1510C Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 2 motifs predicted.

Motif Table (2)
Motif Id e-value Consensus Motif Logo
1463 6.80e+03 GACGcG.TCGtcGacg.C.tC
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1464 3.70e+04 AAACCTACAT
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for VNG1510C

VNG1510C is enriched for 6 functions in 3 categories.
Enrichment Table (6)
Function System
Histone acetyltransferase cog/ cog
histone acetyltransferase activity go/ molecular_function
N-acetyltransferase activity go/ molecular_function
metabolic process go/ biological_process
iron-sulfur cluster binding go/ molecular_function
ELP3 tigr/ tigrfam
Module neighborhood information for VNG1510C

VNG1510C has total of 30 gene neighbors in modules 265
Gene neighbors (30)
Gene Common Name Description Module membership
VNG0009G graD2 glucose-1-phosphate thymidylyltransferase 194, 265
VNG0045C hypothetical protein VNG0045C 196, 265
VNG0084G moeB molybdenum cofactor biosynthesis protein 169, 256, 265, 300
VNG0128C hypothetical protein VNG0128C 252, 265
VNG0157G oxlT oxalate/formate antiporter 53, 265
VNG0164G hef hydrogenase expression/formation 190, 265
VNG0171C hypothetical protein VNG0171C 115, 265
VNG0186G pepB1 aminopeptidase-like protein 190, 265
VNG0188H hypothetical protein VNG0188H 246, 265
VNG0199H hypothetical protein VNG0199H 108, 265
VNG0485H hypothetical protein VNG0485H 265
VNG0676C hypothetical protein VNG0676C 265
VNG0723G pepQ1 putative peptidase 265
VNG0913H hypothetical protein VNG0913H 265
VNG0930G yvbT alkanal monooxygenase-like protein 265, 282
VNG1229H hypothetical protein VNG1229H 265
VNG1303C hypothetical protein VNG1303C 265, 285, 288
VNG1410H hypothetical protein VNG1410H 265
VNG1510C hypothetical protein VNG1510C 265
VNG1619H hypothetical protein VNG1619H 265
VNG1791C hypothetical protein VNG1791C 265
VNG1833C hypothetical protein VNG1833C 265
VNG2180C hypothetical protein VNG2180C 265, 271
VNG2203G prsA hypothetical protein VNG2203G 265
VNG2264C hypothetical protein VNG2264C 265
VNG2524H hypothetical protein VNG2524H 265
VNG2558G fepC hypothetical protein VNG2558G 265
VNG2656H hypothetical protein VNG2656H 265
VNG6247G trkA4 TRK potassium uptake system protein 265
VNG6385H hypothetical protein VNG6385H 265, 297
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for VNG1510C
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend