| COG0085 | DNA-directed RNA polymerase, beta subunit/140 kD subunit |
| COG0086 | DNA-directed RNA polymerase, beta' subunit/160 kD subunit |
| COG0195 | Transcription elongation factor |
| COG0202 | DNA-directed RNA polymerase, alpha subunit/40 kD subunit |
| COG0250 | Transcription antiterminator |
| COG0317 | Guanosine polyphosphate pyrophosphohydrolases/synthetases |
| COG0378 | Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase |
| COG0454 | Histone acetyltransferase HPA2 and related acetyltransferases |
| COG0513 | Superfamily II DNA and RNA helicases |
| COG0515 | Serine/threonine protein kinase |
| COG0553 | Superfamily II DNA/RNA helicases, SNF2 family |
| COG0557 | Exoribonuclease R |
| COG0568 | DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) |
| COG0571 | dsRNA-specific ribonuclease |
| COG0583 | Transcriptional regulator |
| COG0640 | Predicted transcriptional regulators |
| COG0745 | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain |
| COG0781 | Transcription termination factor |
| COG0782 | Transcription elongation factor |
| COG0789 | Predicted transcriptional regulators |
| COG0819 | Putative transcription activator |
| COG0846 | NAD-dependent protein deacetylases, SIR2 family |
| COG0864 | Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain |
| COG1061 | DNA or RNA helicases of superfamily II |
| COG1095 | DNA-directed RNA polymerase, subunit E' |
| COG1158 | Transcription termination factor |
| COG1167 | Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs |
| COG1191 | DNA-directed RNA polymerase specialized sigma subunit |
| COG1197 | Transcription-repair coupling factor (superfamily II helicase) |
| COG1199 | Rad3-related DNA helicases |
| COG1200 | RecG-like helicase |
| COG1221 | Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain |
| COG1224 | DNA helicase TIP49, TBP-interacting protein |
| COG1243 | Histone acetyltransferase |
| COG1278 | Cold shock proteins |
| COG1293 | Predicted RNA-binding protein homologous to eukaryotic snRNP |
| COG1308 | Transcription factor homologous to NACalpha-BTF3 |
| COG1309 | Transcriptional regulator |
| COG1316 | Transcriptional regulator |
| COG1318 | Predicted transcriptional regulators |
| COG1321 | Mn-dependent transcriptional regulator |
| COG1327 | Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains |
| COG1329 | Transcriptional regulators, similar to M. xanthus CarD |
| COG1339 | Transcriptional regulator of a riboflavin/FAD biosynthetic operon |
| COG1349 | Transcriptional regulators of sugar metabolism |
| COG1378 | Predicted transcriptional regulators |
| COG1386 | Predicted transcriptional regulator containing the HTH domain |
| COG1395 | Predicted transcriptional regulator |
| COG1396 | Predicted transcriptional regulators |
| COG1405 | Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB |
| COG1414 | Transcriptional regulator |
| COG1420 | Transcriptional regulator of heat shock gene |
| COG1438 | Arginine repressor |
| COG1475 | Predicted transcriptional regulators |
| COG1476 | Predicted transcriptional regulators |
| COG1497 | Predicted transcriptional regulator |
| COG1508 | DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog |
| COG1510 | Predicted transcriptional regulators |
| COG1521 | Putative transcriptional regulator, homolog of Bvg accessory factor |
| COG1522 | Transcriptional regulators |
| COG1548 | Predicted transcriptional regulator/sugar kinase |
| COG1581 | Archaeal DNA-binding protein |
| COG1594 | DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS |
| COG1595 | DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog |
| COG1609 | Transcriptional regulators |
| COG1644 | DNA-directed RNA polymerase, subunit N (RpoN/RPB10) |
| COG1654 | Biotin operon repressor |
| COG1675 | Transcription initiation factor IIE, alpha subunit |
| COG1678 | Putative transcriptional regulator |
| COG1695 | Predicted transcriptional regulators |
| COG1709 | Predicted transcriptional regulator |
| COG1725 | Predicted transcriptional regulators |
| COG1733 | Predicted transcriptional regulators |
| COG1737 | Transcriptional regulators |
| COG1758 | DNA-directed RNA polymerase, subunit K/omega |
| COG1761 | DNA-directed RNA polymerase, subunit L |
| COG1777 | Predicted transcriptional regulators |
| COG1802 | Transcriptional regulators |
| COG1813 | Predicted transcription factor, homolog of eukaryotic MBF1 |
| COG1842 | Phage shock protein A (IM30), suppresses sigma54-dependent transcription |
| COG1846 | Transcriptional regulators |
| COG1940 | Transcriptional regulator/sugar kinase |
| COG1954 | Glycerol-3-phosphate responsive antiterminator (mRNA-binding) |
| COG1958 | Small nuclear ribonucleoprotein (snRNP) homolog |
| COG1959 | Predicted transcriptional regulator |
| COG1974 | SOS-response transcriptional repressors (RecA-mediated autopeptidases) |
| COG1983 | Putative stress-responsive transcriptional regulator |
| COG1996 | DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) |
| COG2002 | Regulators of stationary/sporulation gene expression |
| COG2012 | DNA-directed RNA polymerase, subunit H, RpoH/RPB5 |
| COG2093 | DNA-directed RNA polymerase, subunit E'' |
| COG2101 | TATA-box binding protein (TBP), component of TFIID and TFIIIB |
| COG2183 | Transcriptional accessory protein |
| COG2186 | Transcriptional regulators |
| COG2188 | Transcriptional regulators |
| COG2197 | Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain |
| COG2207 | AraC-type DNA-binding domain-containing proteins |
| COG2208 | Serine phosphatase RsbU, regulator of sigma subunit |
| COG2345 | Predicted transcriptional regulator |
| COG2378 | Predicted transcriptional regulator |
| COG2390 | Transcriptional regulator, contains sigma factor-related N-terminal domain |
| COG2524 | Predicted transcriptional regulator, contains C-terminal CBS domains |
| COG2732 | Barstar, RNAse (barnase) inhibitor |
| COG2740 | Predicted nucleic-acid-binding protein implicated in transcription termination |
| COG2747 | Negative regulator of flagellin synthesis (anti-sigma28 factor) |
| COG2771 | DNA-binding HTH domain-containing proteins |
| COG2808 | Transcriptional regulator |
| COG2865 | Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen |
| COG2901 | Factor for inversion stimulation Fis, transcriptional activator |
| COG2909 | ATP-dependent transcriptional regulator |
| COG2932 | Predicted transcriptional regulator |
| COG2944 | Predicted transcriptional regulator |
| COG2973 | Trp operon repressor |
| COG3060 | Transcriptional regulator of met regulon |
| COG3070 | Regulator of competence-specific genes |
| COG3160 | Regulator of sigma D |
| COG3279 | Response regulator of the LytR/AlgR family |
| COG3283 | Transcriptional regulator of aromatic amino acids metabolism |
| COG3284 | Transcriptional activator of acetoin/glycerol metabolism |
| COG3311 | Predicted transcriptional regulator |
| COG3327 | Phenylacetic acid-responsive transcriptional repressor |
| COG3343 | DNA-directed RNA polymerase, delta subunit |
| COG3355 | Predicted transcriptional regulator |
| COG3357 | Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon |
| COG3423 | Predicted transcriptional regulator |
| COG3432 | Predicted transcriptional regulator |
| COG3437 | Response regulator containing a CheY-like receiver domain and an HD-GYP domain |
| COG3561 | Phage anti-repressor protein |
| COG3604 | Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains |
| COG3609 | Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain |
| COG3617 | Prophage antirepressor |
| COG3620 | Predicted transcriptional regulator with C-terminal CBS domains |
| COG3636 | Predicted transcriptional regulator |
| COG3655 | Predicted transcriptional regulator |
| COG3682 | Predicted transcriptional regulator |
| COG3710 | DNA-binding winged-HTH domains |
| COG3711 | Transcriptional antiterminator |
| COG3722 | Transcriptional regulator |
| COG3829 | Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains |
| COG3835 | Sugar diacid utilization regulator |
| COG3888 | Predicted transcriptional regulator |
| COG3901 | Regulator of nitric oxide reductase transcription |
| COG3905 | Predicted transcriptional regulator |
| COG3933 | Transcriptional antiterminator |
| COG4008 | Predicted metal-binding transcription factor |
| COG4109 | Predicted transcriptional regulator containing CBS domains |
| COG4189 | Predicted transcriptional regulator |
| COG4190 | Predicted transcriptional regulator |
| COG4219 | Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component |
| COG4271 | Predicted nucleotide-binding protein containing TIR -like domain |
| COG4463 | Transcriptional repressor of class III stress genes |
| COG4465 | Pleiotropic transcriptional repressor |
| COG4512 | Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide |
| COG4565 | Response regulator of citrate/malate metabolism |
| COG4567 | Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain |
| COG4568 | Transcriptional antiterminator |
| COG4578 | Glucitol operon activator |
| COG4646 | DNA methylase |
| COG4650 | Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain |
| COG4725 | Transcriptional activator, adenine-specific DNA methyltransferase |
| COG4738 | Predicted transcriptional regulator |
| COG4742 | Predicted transcriptional regulator |
| COG4776 | Exoribonuclease II |
| COG4800 | Predicted transcriptional regulator with an HTH domain |
| COG4903 | Genetic competence transcription factor |
| COG4936 | Predicted sensor domain |
| COG4941 | Predicted RNA polymerase sigma factor containing a TPR repeat domain |
| COG4957 | Predicted transcriptional regulator |
| COG4977 | Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain |
| COG4978 | Transcriptional regulator, effector-binding domain/component |
| COG5007 | Predicted transcriptional regulator, BolA superfamily |
| COG5025 | Transcription factor of the Forkhead/HNF3 family |
| COG5033 | Transcription initiation factor IIF, auxiliary subunit |
| COG5035 | Cell cycle control protein |
| COG5041 | Casein kinase II, beta subunit |
| COG5068 | Regulator of arginine metabolism and related MADS box-containing transcription factors |
| COG5076 | Transcription factor involved in chromatin remodeling, contains bromodomain |
| COG5090 | Transcription initiation factor IIF, small subunit (RAP30) |
| COG5094 | Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) |
| COG5095 | Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) |
| COG5097 | RNA polymerase II transcriptional regulation mediator |
| COG5103 | Cell division control protein, negative regulator of transcription |
| COG5108 | Mitochondrial DNA-directed RNA polymerase |
| COG5111 | DNA-directed RNA polymerase III, subunit C34 |
| COG5118 | Transcription initiation factor TFIIIB, Bdp1 subunit |
| COG5123 | Transcription initiation factor IIA, gamma subunit |
| COG5132 | Cell cycle control protein, G10 family |
| COG5137 | Histone chaperone involved in gene silencing |
| COG5144 | RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2 |
| COG5147 | Myb superfamily proteins, including transcription factors and mRNA splicing factors |
| COG5149 | Transcription initiation factor IIA, large chain |
| COG5150 | Class 2 transcription repressor NC2, beta subunit (Dr1) |
| COG5151 | RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 |
| COG5157 | RNA polymerase II assessory factor |
| COG5162 | Transcription initiation factor TFIID, subunit TAF10 (also component of histone acetyltransferase SAGA) |
| COG5164 | Transcription elongation factor |
| COG5165 | Nucleosome-binding factor SPN, POB3 subunit |
| COG5169 | Heat shock transcription factor |
| COG5174 | Transcription initiation factor IIE, beta subunit |
| COG5175 | Transcriptional repressor |
| COG5179 | Transcription initiation factor TFIID, subunit TAF1 |
| COG5189 | Putative transcriptional repressor regulating G2/M transition |
| COG5190 | TFIIF-interacting CTD phosphatases, including NLI-interacting factor |
| COG5204 | Transcription elongation factor SPT4 |
| COG5208 | CCAAT-binding factor, subunit C |
| COG5211 | RNA polymerase II-interacting protein involved in transcription start site selection |
| COG5220 | Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3 |
| COG5221 | Dopey and related predicted leucine zipper transcription factors |
| COG5224 | CCAAT-binding factor, subunit B |
| COG5242 | RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4 |
| COG5247 | Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) |
| COG5248 | Transcription initiation factor TFIID, subunit TAF13 |
| COG5250 | RNA polymerase II, fourth largest subunit |
| COG5251 | Transcription initiation factor TFIID, subunit TAF11 |
| COG5259 | RSC chromatin remodeling complex subunit RSC8 |
| COG5290 | IkappaB kinase complex, IKAP component |
| COG5296 | Transcription factor involved in TATA site selection and in elongation by RNA polymerase II |
| COG5333 | Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit |
| COG5340 | Predicted transcriptional regulator |
| COG5406 | Nucleosome binding factor SPN, SPT16 subunit |
| COG5414 | TATA-binding protein-associated factor |
| COG5450 | Transcription regulator of the Arc/MetJ class |
| COG5499 | Predicted transcription regulator containing HTH domain |
| COG5576 | Homeodomain-containing transcription factor |
| COG5601 | General negative regulator of transcription subunit |
| COG5624 | Transcription initiation factor TFIID, subunit TAF12 (also component of histone acetyltransferase SAGA) |
| COG5625 | Predicted transcription regulator containing HTH domain |
| COG5631 | Predicted transcription regulator, contains HTH domain (MarR family) |
| COG5641 | GATA Zn-finger-containing transcription factor |
| COG5662 | Predicted transmembrane transcriptional regulator (anti-sigma factor) |
| COG5665 | CCR4-NOT transcriptional regulation complex, NOT5 subunit |