| COG0286 | Type I restriction-modification system methyltransferase subunit |
| COG0534 | Na+-driven multidrug efflux pump |
| COG0577 | ABC-type antimicrobial peptide transport system, permease component |
| COG0610 | Type I site-specific restriction-modification system, R (restriction) subunit and related helicases |
| COG0732 | Restriction endonuclease S subunits |
| COG0841 | Cation/multidrug efflux pump |
| COG0842 | ABC-type multidrug transport system, permease component |
| COG1002 | Type II restriction enzyme, methylase subunits |
| COG1131 | ABC-type multidrug transport system, ATPase component |
| COG1132 | ABC-type multidrug transport system, ATPase and permease components |
| COG1136 | ABC-type antimicrobial peptide transport system, ATPase component |
| COG1401 | GTPase subunit of restriction endonuclease |
| COG1403 | Restriction endonuclease |
| COG1566 | Multidrug resistance efflux pump |
| COG1619 | Uncharacterized proteins, homologs of microcin C7 resistance protein MccF |
| COG1680 | Beta-lactamase class C and other penicillin binding proteins |
| COG1715 | Restriction endonuclease |
| COG1787 | Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes |
| COG1968 | Uncharacterized bacitracin resistance protein |
| COG2274 | ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain |
| COG2348 | Uncharacterized protein involved in methicillin resistance |
| COG2367 | Beta-lactamase class A |
| COG2602 | Beta-lactamase class D |
| COG2720 | Uncharacterized vancomycin resistance protein |
| COG2746 | Aminoglycoside N3'-acetyltransferase |
| COG2810 | Predicted type IV restriction endonuclease |
| COG3023 | Negative regulator of beta-lactamase expression |
| COG3183 | Predicted restriction endonuclease |
| COG3440 | Predicted restriction endonuclease |
| COG3510 | Cephalosporin hydroxylase |
| COG3570 | Streptomycin 6-kinase |
| COG3587 | Restriction endonuclease |
| COG3725 | Membrane protein required for beta-lactamase induction |
| COG3896 | Chloramphenicol 3-O-phosphotransferase |
| COG4096 | Type I site-specific restriction-modification system, R (restriction) subunit and related helicases |
| COG4167 | ABC-type antimicrobial peptide transport system, ATPase component |
| COG4168 | ABC-type antimicrobial peptide transport system, permease component |
| COG4170 | ABC-type antimicrobial peptide transport system, ATPase component |
| COG4171 | ABC-type antimicrobial peptide transport system, permease component |
| COG4257 | Streptogramin lyase |
| COG4268 | McrBC 5-methylcytosine restriction system component |
| COG4403 | Lantibiotic modifying enzyme |
| COG4452 | Inner membrane protein involved in colicin E2 resistance |
| COG4767 | Glycopeptide antibiotics resistance protein |
| COG4823 | Abortive infection bacteriophage resistance protein |
| COG4845 | Chloramphenicol O-acetyltransferase |
