| COG0073 | EMAP domain |
| COG0110 | Acetyltransferase (isoleucine patch superfamily) |
| COG0121 | Predicted glutamine amidotransferase |
| COG0218 | Predicted GTPase |
| COG0220 | Predicted S-adenosylmethionine-dependent methyltransferase |
| COG0300 | Short-chain dehydrogenases of various substrate specificities |
| COG0312 | Predicted Zn-dependent proteases and their inactivated homologs |
| COG0313 | Predicted methyltransferases |
| COG0319 | Predicted metal-dependent hydrolase |
| COG0325 | Predicted enzyme with a TIM-barrel fold |
| COG0354 | Predicted aminomethyltransferase related to GcvT |
| COG0375 | Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) |
| COG0384 | Predicted epimerase, PhzC/PhzF homolog |
| COG0385 | Predicted Na+-dependent transporter |
| COG0388 | Predicted amidohydrolase |
| COG0390 | ABC-type uncharacterized transport system, permease component |
| COG0400 | Predicted esterase |
| COG0402 | Cytosine deaminase and related metal-dependent hydrolases |
| COG0429 | Predicted hydrolase of the alpha/beta-hydrolase fold |
| COG0431 | Predicted flavoprotein |
| COG0433 | Predicted ATPase |
| COG0434 | Predicted TIM-barrel enzyme |
| COG0446 | Uncharacterized NAD(FAD)-dependent dehydrogenases |
| COG0454 | Histone acetyltransferase HPA2 and related acetyltransferases |
| COG0456 | Acetyltransferases |
| COG0457 | FOG: TPR repeat |
| COG0477 | Permeases of the major facilitator superfamily |
| COG0486 | Predicted GTPase |
| COG0488 | ATPase components of ABC transporters with duplicated ATPase domains |
| COG0491 | Zn-dependent hydrolases, including glyoxylases |
| COG0493 | NADPH-dependent glutamate synthase beta chain and related oxidoreductases |
| COG0494 | NTP pyrophosphohydrolases including oxidative damage repair enzymes |
| COG0496 | Predicted acid phosphatase |
| COG0500 | SAM-dependent methyltransferases |
| COG0515 | Serine/threonine protein kinase |
| COG0517 | FOG: CBS domain |
| COG0523 | Putative GTPases (G3E family) |
| COG0535 | Predicted Fe-S oxidoreductases |
| COG0536 | Predicted GTPase |
| COG0537 | Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases |
| COG0546 | Predicted phosphatases |
| COG0561 | Predicted hydrolases of the HAD superfamily |
| COG0579 | Predicted dehydrogenase |
| COG0591 | Na+/proline symporter |
| COG0595 | Predicted hydrolase of the metallo-beta-lactamase superfamily |
| COG0596 | Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) |
| COG0603 | Predicted PP-loop superfamily ATPase |
| COG0604 | NADPH:quinone reductase and related Zn-dependent oxidoreductases |
| COG0612 | Predicted Zn-dependent peptidases |
| COG0613 | Predicted metal-dependent phosphoesterases (PHP family) |
| COG0618 | Exopolyphosphatase-related proteins |
| COG0622 | Predicted phosphoesterase |
| COG0627 | Predicted esterase |
| COG0628 | Predicted permease |
| COG0637 | Predicted phosphatase/phosphohexomutase |
| COG0641 | Arylsulfatase regulator (Fe-S oxidoreductase) |
| COG0645 | Predicted kinase |
| COG0655 | Multimeric flavodoxin WrbA |
| COG0656 | Aldo/keto reductases, related to diketogulonate reductase |
| COG0658 | Predicted membrane metal-binding protein |
| COG0661 | Predicted unusual protein kinase |
| COG0663 | Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily |
| COG0666 | FOG: Ankyrin repeat |
| COG0670 | Integral membrane protein, interacts with FtsH |
| COG0673 | Predicted dehydrogenases and related proteins |
| COG0679 | Predicted permeases |
| COG0693 | Putative intracellular protease/amidase |
| COG0697 | Permeases of the drug/metabolite transporter (DMT) superfamily |
| COG0699 | Predicted GTPases (dynamin-related) |
| COG0701 | Predicted permeases |
| COG0705 | Uncharacterized membrane protein (homolog of Drosophila rhomboid) |
| COG0714 | MoxR-like ATPases |
| COG0724 | RNA-binding proteins (RRM domain) |
| COG0727 | Predicted Fe-S-cluster oxidoreductase |
| COG0728 | Uncharacterized membrane protein, putative virulence factor |
| COG0730 | Predicted permeases |
| COG0733 | Na+-dependent transporters of the SNF family |
| COG0780 | Enzyme related to GTP cyclohydrolase I |
| COG0790 | FOG: TPR repeat, SEL1 subfamily |
| COG0795 | Predicted permeases |
| COG0802 | Predicted ATPase or kinase |
| COG0820 | Predicted Fe-S-cluster redox enzyme |
| COG0824 | Predicted thioesterase |
| COG0857 | BioD-like N-terminal domain of phosphotransacetylase |
| COG1011 | Predicted hydrolase (HAD superfamily) |
| COG1019 | Predicted nucleotidyltransferase |
| COG1026 | Predicted Zn-dependent peptidases, insulinase-like |
| COG1028 | Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) |
| COG1033 | Predicted exporters of the RND superfamily |
| COG1040 | Predicted amidophosphoribosyltransferases |
| COG1052 | Lactate dehydrogenase and related dehydrogenases |
| COG1054 | Predicted sulfurtransferase |
| COG1058 | Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA |
| COG1060 | Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes |
| COG1063 | Threonine dehydrogenase and related Zn-dependent dehydrogenases |
| COG1064 | Zn-dependent alcohol dehydrogenases |
| COG1073 | Hydrolases of the alpha/beta superfamily |
| COG1075 | Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold |
| COG1078 | HD superfamily phosphohydrolases |
| COG1079 | Uncharacterized ABC-type transport system, permease component |
| COG1084 | Predicted GTPase |
| COG1090 | Predicted nucleoside-diphosphate sugar epimerase |
| COG1092 | Predicted SAM-dependent methyltransferases |
| COG1094 | Predicted RNA-binding protein (contains KH domains) |
| COG1099 | Predicted metal-dependent hydrolases with the TIM-barrel fold |
| COG1100 | GTPase SAR1 and related small G proteins |
| COG1101 | ABC-type uncharacterized transport system, ATPase component |
| COG1103 | Archaea-specific pyridoxal phosphate-dependent enzymes |
| COG1106 | Predicted ATPases |
| COG1123 | ATPase components of various ABC-type transport systems, contain duplicated ATPase |
| COG1137 | ABC-type (unclassified) transport system, ATPase component |
| COG1159 | GTPase |
| COG1160 | Predicted GTPases |
| COG1161 | Predicted GTPases |
| COG1162 | Predicted GTPases |
| COG1163 | Predicted GTPase |
| COG1201 | Lhr-like helicases |
| COG1202 | Superfamily II helicase, archaea-specific |
| COG1203 | Predicted helicases |
| COG1204 | Superfamily II helicase |
| COG1205 | Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster |
| COG1216 | Predicted glycosyltransferases |
| COG1223 | Predicted ATPase (AAA+ superfamily) |
| COG1234 | Metal-dependent hydrolases of the beta-lactamase superfamily III |
| COG1235 | Metal-dependent hydrolases of the beta-lactamase superfamily I |
| COG1237 | Metal-dependent hydrolases of the beta-lactamase superfamily II |
| COG1242 | Predicted Fe-S oxidoreductase |
| COG1244 | Predicted Fe-S oxidoreductase |
| COG1245 | Predicted ATPase, RNase L inhibitor (RLI) homolog |
| COG1253 | Hemolysins and related proteins containing CBS domains |
| COG1266 | Predicted metal-dependent membrane protease |
| COG1268 | Uncharacterized conserved protein |
| COG1272 | Predicted membrane protein, hemolysin III homolog |
| COG1277 | ABC-type transport system involved in multi-copper enzyme maturation, permease component |
| COG1279 | Lysine efflux permease |
| COG1286 | Uncharacterized membrane protein, required for colicin V production |
| COG1287 | Uncharacterized membrane protein, required for N-linked glycosylation |
| COG1310 | Predicted metal-dependent protease of the PAD1/JAB1 superfamily |
| COG1313 | Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins |
| COG1323 | Predicted nucleotidyltransferase |
| COG1326 | Uncharacterized archaeal Zn-finger protein |
| COG1341 | Predicted GTPase or GTP-binding protein |
| COG1342 | Predicted DNA-binding proteins |
| COG1350 | Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) |
| COG1353 | Predicted hydrolase of the HD superfamily (permuted catalytic motifs) |
| COG1355 | Predicted dioxygenase |
| COG1365 | Predicted ATPase (PP-loop superfamily) |
| COG1373 | Predicted ATPase (AAA+ superfamily) |
| COG1380 | Putative effector of murein hydrolase LrgA |
| COG1387 | Histidinol phosphatase and related hydrolases of the PHP family |
| COG1399 | Predicted metal-binding, possibly nucleic acid-binding protein |
| COG1402 | Uncharacterized protein, putative amidase |
| COG1407 | Predicted ICC-like phosphoesterases |
| COG1408 | Predicted phosphohydrolases |
| COG1409 | Predicted phosphohydrolases |
| COG1411 | Uncharacterized protein related to proFAR isomerase (HisA) |
| COG1412 | Uncharacterized proteins of PilT N-term./Vapc superfamily |
| COG1418 | Predicted HD superfamily hydrolase |
| COG1427 | Predicted periplasmic solute-binding protein |
| COG1439 | Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module |
| COG1444 | Predicted P-loop ATPase fused to an acetyltransferase |
| COG1451 | Predicted metal-dependent hydrolase |
| COG1453 | Predicted oxidoreductases of the aldo/keto reductase family |
| COG1458 | Predicted DNA-binding protein containing PIN domain |
| COG1461 | Predicted kinase related to dihydroxyacetone kinase |
| COG1473 | Metal-dependent amidase/aminoacylase/carboxypeptidase |
| COG1480 | Predicted membrane-associated HD superfamily hydrolase |
| COG1483 | Predicted ATPase (AAA+ superfamily) |
| COG1485 | Predicted ATPase |
| COG1487 | Predicted nucleic acid-binding protein, contains PIN domain |
| COG1489 | DNA-binding protein, stimulates sugar fermentation |
| COG1512 | Beta-propeller domains of methanol dehydrogenase type |
| COG1524 | Uncharacterized proteins of the AP superfamily |
| COG1532 | Predicted RNA-binding protein |
| COG1537 | Predicted RNA-binding proteins |
| COG1540 | Uncharacterized proteins, homologs of lactam utilization protein B |
| COG1545 | Predicted nucleic-acid-binding protein containing a Zn-ribbon |
| COG1546 | Uncharacterized protein (competence- and mitomycin-induced) |
| COG1559 | Predicted periplasmic solute-binding protein |
| COG1568 | Predicted methyltransferases |
| COG1569 | Predicted nucleic acid-binding protein, contains PIN domain |
| COG1571 | Predicted DNA-binding protein containing a Zn-ribbon domain |
| COG1574 | Predicted metal-dependent hydrolase with the TIM-barrel fold |
| COG1579 | Zn-ribbon protein, possibly nucleic acid-binding |
| COG1597 | Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase |
| COG1606 | ATP-utilizing enzymes of the PP-loop superfamily |
| COG1608 | Predicted archaeal kinase |
| COG1611 | Predicted Rossmann fold nucleotide-binding protein |
| COG1623 | Predicted nucleic-acid-binding protein (contains the HHH domain) |
| COG1634 | Uncharacterized Rossmann fold enzyme |
| COG1645 | Uncharacterized Zn-finger containing protein |
| COG1646 | Predicted phosphate-binding enzymes, TIM-barrel fold |
| COG1647 | Esterase/lipase |
| COG1660 | Predicted P-loop-containing kinase |
| COG1661 | Predicted DNA-binding protein with PD1-like DNA-binding motif |
| COG1669 | Predicted nucleotidyltransferases |
| COG1672 | Predicted ATPase (AAA+ superfamily) |
| COG1691 | NCAIR mutase (PurE)-related proteins |
| COG1694 | Predicted pyrophosphatase |
| COG1707 | ACT domain-containing protein |
| COG1708 | Predicted nucleotidyltransferases |
| COG1712 | Predicted dinucleotide-utilizing enzyme |
| COG1719 | Predicted hydrocarbon binding protein (contains V4R domain) |
| COG1721 | Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) |
| COG1735 | Predicted metal-dependent hydrolase with the TIM-barrel fold |
| COG1741 | Pirin-related protein |
| COG1744 | Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein |
| COG1745 | Predicted metal-binding protein |
| COG1750 | Archaeal serine proteases |
| COG1752 | Predicted esterase of the alpha-beta hydrolase superfamily |
| COG1754 | Uncharacterized C-terminal domain of topoisomerase IA |
| COG1759 | ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) |
| COG1768 | Predicted phosphohydrolase |
| COG1778 | Low specificity phosphatase (HAD superfamily) |
| COG1779 | C4-type Zn-finger protein |
| COG1782 | Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain |
| COG1783 | Phage terminase large subunit |
| COG1800 | Predicted transglutaminase-like proteases |
| COG1811 | Uncharacterized membrane protein, possible Na+ channel or pump |
| COG1818 | Predicted RNA-binding protein, contains THUMP domain |
| COG1821 | Predicted ATP-utilizing enzyme (ATP-grasp superfamily) |
| COG1823 | Predicted Na+/dicarboxylate symporter |
| COG1827 | Predicted small molecule binding protein (contains 3H domain) |
| COG1829 | Predicted archaeal kinase (sugar kinase superfamily) |
| COG1831 | Predicted metal-dependent hydrolase (urease superfamily) |
| COG1832 | Predicted CoA-binding protein |
| COG1837 | Predicted RNA-binding protein (contains KH domain) |
| COG1847 | Predicted RNA-binding protein |
| COG1848 | Predicted nucleic acid-binding protein, contains PIN domain |
| COG1853 | Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family |
| COG1855 | ATPase (PilT family) |
| COG1878 | Predicted metal-dependent hydrolase |
| COG1881 | Phospholipid-binding protein |
| COG1896 | Predicted hydrolases of HD superfamily |
| COG1907 | Predicted archaeal sugar kinases |
| COG1913 | Predicted Zn-dependent proteases |
| COG1923 | Uncharacterized host factor I protein |
| COG1926 | Predicted phosphoribosyltransferases |
| COG1938 | Archaeal enzymes of ATP-grasp superfamily |
| COG1942 | Uncharacterized protein, 4-oxalocrotonate tautomerase homolog |
| COG1964 | Predicted Fe-S oxidoreductases |
| COG1988 | Predicted membrane-bound metal-dependent hydrolases |
| COG1994 | Zn-dependent proteases |
| COG1999 | Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems |
| COG2000 | Predicted Fe-S protein |
| COG2005 | N-terminal domain of molybdenum-binding protein |
| COG2018 | Uncharacterized distant relative of homeotic protein bithoraxoid |
| COG2041 | Sulfite oxidase and related enzymes |
| COG2044 | Predicted peroxiredoxins |
| COG2045 | Phosphosulfolactate phosphohydrolase and related enzymes |
| COG2047 | Uncharacterized protein (ATP-grasp superfamily) |
| COG2054 | Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases |
| COG2056 | Predicted permease |
| COG2068 | Uncharacterized MobA-related protein |
| COG2070 | Dioxygenases related to 2-nitropropane dioxygenase |
| COG2071 | Predicted glutamine amidotransferases |
| COG2079 | Uncharacterized protein involved in propionate catabolism |
| COG2081 | Predicted flavoproteins |
| COG2085 | Predicted dinucleotide-binding enzymes |
| COG2100 | Predicted Fe-S oxidoreductase |
| COG2102 | Predicted ATPases of PP-loop superfamily |
| COG2103 | Predicted sugar phosphate isomerase |
| COG2107 | Predicted periplasmic solute-binding protein |
| COG2108 | Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme |
| COG2110 | Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 |
| COG2118 | DNA-binding protein |
| COG2129 | Predicted phosphoesterases, related to the Icc protein |
| COG2130 | Putative NADP-dependent oxidoreductases |
| COG2137 | Uncharacterized protein conserved in bacteria |
| COG2140 | Thermophilic glucose-6-phosphate isomerase and related metalloenzymes |
| COG2144 | Selenophosphate synthetase-related proteins |
| COG2146 | Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases |
| COG2150 | Predicted regulator of amino acid metabolism, contains ACT domain |
| COG2151 | Predicted metal-sulfur cluster biosynthetic enzyme |
| COG2153 | Predicted acyltransferase |
| COG2158 | Uncharacterized protein containing a Zn-finger-like domain |
| COG2159 | Predicted metal-dependent hydrolase of the TIM-barrel fold |
| COG2166 | SufE protein probably involved in Fe-S center assembly |
| COG2179 | Predicted hydrolase of the HAD superfamily |
| COG2194 | Predicted membrane-associated, metal-dependent hydrolase |
| COG2215 | ABC-type uncharacterized transport system, permease component |
| COG2220 | Predicted Zn-dependent hydrolases of the beta-lactamase fold |
| COG2229 | Predicted GTPase |
| COG2232 | Predicted ATP-dependent carboligase related to biotin carboxylase |
| COG2234 | Predicted aminopeptidases |
| COG2236 | Predicted phosphoribosyltransferases |
| COG2244 | Membrane protein involved in the export of O-antigen and teichoic acid |
| COG2248 | Predicted hydrolase (metallo-beta-lactamase superfamily) |
| COG2249 | Putative NADPH-quinone reductase (modulator of drug activity B) |
| COG2251 | Predicted nuclease (RecB family) |
| COG2252 | Permeases |
| COG2262 | GTPases |
| COG2270 | Permeases of the major facilitator superfamily |
| COG2304 | Uncharacterized protein containing a von Willebrand factor type A (vWA) domain |
| COG2312 | Erythromycin esterase homolog |
| COG2316 | Predicted hydrolase (HD superfamily) |
| COG2319 | FOG: WD40 repeat |
| COG2321 | Predicted metalloprotease |
| COG2329 | Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides |
| COG2333 | Predicted hydrolase (metallo-beta-lactamase superfamily) |
| COG2334 | Putative homoserine kinase type II (protein kinase fold) |
| COG2344 | AT-rich DNA-binding protein |
| COG2346 | Truncated hemoglobins |
| COG2351 | Transthyretin-like protein |
| COG2358 | TRAP-type uncharacterized transport system, periplasmic component |
| COG2366 | Protein related to penicillin acylase |
| COG2372 | Uncharacterized protein, homolog of Cu resistance protein CopC |
| COG2373 | Large extracellular alpha-helical protein |
| COG2374 | Predicted extracellular nuclease |
| COG2384 | Predicted SAM-dependent methyltransferase |
| COG2388 | Predicted acetyltransferase |
| COG2389 | Uncharacterized metal-binding protein |
| COG2391 | Predicted transporter component |
| COG2401 | ABC-type ATPase fused to a predicted acetyltransferase domain |
| COG2402 | Predicted nucleic acid-binding protein, contains PIN domain |
| COG2403 | Predicted GTPase |
| COG2404 | Predicted phosphohydrolase (DHH superfamily) |
| COG2405 | Predicted nucleic acid-binding protein, contains PIN domain |
| COG2406 | Protein distantly related to bacterial ferritins |
| COG2409 | Predicted drug exporters of the RND superfamily |
| COG2413 | Predicted nucleotidyltransferase |
| COG2425 | Uncharacterized protein containing a von Willebrand factor type A (vWA) domain |
| COG2503 | Predicted secreted acid phosphatase |
| COG2509 | Uncharacterized FAD-dependent dehydrogenases |
| COG2514 | Predicted ring-cleavage extradiol dioxygenase |
| COG2516 | Biotin synthase-related enzyme |
| COG2517 | Predicted RNA-binding protein containing a C-terminal EMAP domain |
| COG2520 | Predicted methyltransferase |
| COG2521 | Predicted archaeal methyltransferase |
| COG2522 | Predicted transcriptional regulator |
| COG2603 | Predicted ATPase |
| COG2605 | Predicted kinase related to galactokinase and mevalonate kinase |
| COG2607 | Predicted ATPase (AAA+ superfamily) |
| COG2704 | Anaerobic C4-dicarboxylate transporter |
| COG2715 | Uncharacterized membrane protein, required for spore maturation in B.subtilis. |
| COG2738 | Predicted Zn-dependent protease |
| COG2768 | Uncharacterized Fe-S center protein |
| COG2802 | Uncharacterized protein, similar to the N-terminal domain of Lon protease |
| COG2819 | Predicted hydrolase of the alpha/beta superfamily |
| COG2823 | Predicted periplasmic or secreted lipoprotein |
| COG2842 | Uncharacterized ATPase, putative transposase |
| COG2872 | Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain |
| COG2907 | Predicted NAD/FAD-binding protein |
| COG2910 | Putative NADH-flavin reductase |
| COG2915 | Uncharacterized protein involved in purine metabolism |
| COG2916 | DNA-binding protein H-NS |
| COG2933 | Predicted SAM-dependent methyltransferase |
| COG2936 | Predicted acyl esterases |
| COG2940 | Proteins containing SET domain |
| COG2945 | Predicted hydrolase of the alpha/beta superfamily |
| COG2961 | Protein involved in catabolism of external DNA |
| COG2962 | Predicted permeases |
| COG2969 | Stringent starvation protein B |
| COG2984 | ABC-type uncharacterized transport system, periplasmic component |
| COG2985 | Predicted permease |
| COG2992 | Uncharacterized FlgJ-related protein |
| COG3008 | Paraquat-inducible protein B |
| COG3019 | Predicted metal-binding protein |
| COG3030 | Protein affecting phage T7 exclusion by the F plasmid |
| COG3042 | Putative hemolysin |
| COG3044 | Predicted ATPase of the ABC class |
| COG3046 | Uncharacterized protein related to deoxyribodipyrimidine photolyase |
| COG3054 | Predicted transcriptional regulator |
| COG3081 | Nucleoid-associated protein |
| COG3083 | Predicted hydrolase of alkaline phosphatase superfamily |
| COG3093 | Plasmid maintenance system antidote protein |
| COG3106 | Predicted ATPase |
| COG3107 | Putative lipoprotein |
| COG3113 | Predicted NTP binding protein (contains STAS domain) |
| COG3129 | Predicted SAM-dependent methyltransferase |
| COG3136 | Uncharacterized membrane protein required for alginate biosynthesis |
| COG3150 | Predicted esterase |
| COG3153 | Predicted acetyltransferase |
| COG3173 | Predicted aminoglycoside phosphotransferase |
| COG3176 | Putative hemolysin |
| COG3178 | Predicted phosphotransferase related to Ser/Thr protein kinases |
| COG3179 | Predicted chitinase |
| COG3180 | Putative ammonia monooxygenase |
| COG3185 | 4-hydroxyphenylpyruvate dioxygenase and related hemolysins |
| COG3193 | Uncharacterized protein, possibly involved in utilization of glycolate and propanediol |
| COG3211 | Predicted phosphatase |
| COG3217 | Uncharacterized Fe-S protein |
| COG3218 | ABC-type uncharacterized transport system, auxiliary component |
| COG3233 | Predicted deacetylase |
| COG3240 | Phospholipase/lecithinase/hemolysin |
| COG3257 | Uncharacterized protein, possibly involved in glyoxylate utilization |
| COG3269 | Predicted RNA-binding protein, contains TRAM domain |
| COG3271 | Predicted double-glycine peptidase |
| COG3291 | FOG: PKD repeat |
| COG3302 | DMSO reductase anchor subunit |
| COG3313 | Predicted Fe-S protein |
| COG3318 | Predicted metal-binding protein related to the C-terminal domain of SecA |
| COG3324 | Predicted enzyme related to lactoylglutathione lyase |
| COG3329 | Predicted permease |
| COG3331 | Penicillin-binding protein-related factor A, putative recombinase |
| COG3341 | Predicted double-stranded RNA/RNA-DNA hybrid binding protein |
| COG3364 | Zn-ribbon containing protein |
| COG3368 | Predicted permease |
| COG3378 | Predicted ATPase |
| COG3380 | Predicted NAD/FAD-dependent oxidoreductase |
| COG3381 | Uncharacterized component of anaerobic dehydrogenases |
| COG3383 | Uncharacterized anaerobic dehydrogenase |
| COG3393 | Predicted acetyltransferase |
| COG3401 | Fibronectin type 3 domain-containing protein |
| COG3413 | Predicted DNA binding protein |
| COG3417 | Collagen-binding surface adhesin SpaP (antigen I/II family) |
| COG3442 | Predicted glutamine amidotransferase |
| COG3443 | Predicted periplasmic or secreted protein |
| COG3445 | Acid-induced glycyl radical enzyme |
| COG3450 | Predicted enzyme of the cupin superfamily |
| COG3467 | Predicted flavin-nucleotide-binding protein |
| COG3478 | Predicted nucleic-acid-binding protein containing a Zn-ribbon domain |
| COG3481 | Predicted HD-superfamily hydrolase |
| COG3489 | Predicted periplasmic lipoprotein |
| COG3491 | Isopenicillin N synthase and related dioxygenases |
| COG3497 | Phage tail sheath protein FI |
| COG3498 | Phage tail tube protein FII |
| COG3499 | Phage protein U |
| COG3500 | Phage protein D |
| COG3529 | Predicted nucleic-acid-binding protein containing a Zn-ribbon domain |
| COG3541 | Predicted nucleotidyltransferase |
| COG3545 | Predicted esterase of the alpha/beta hydrolase fold |
| COG3549 | Plasmid maintenance system killer protein |
| COG3550 | Uncharacterized protein related to capsule biosynthesis enzymes |
| COG3552 | Protein containing von Willebrand factor type A (vWA) domain |
| COG3560 | Predicted oxidoreductase related to nitroreductase |
| COG3565 | Predicted dioxygenase of extradiol dioxygenase family |
| COG3568 | Metal-dependent hydrolase |
| COG3571 | Predicted hydrolase of the alpha/beta-hydrolase fold |
| COG3573 | Predicted oxidoreductase |
| COG3576 | Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase |
| COG3577 | Predicted aspartyl protease |
| COG3582 | Predicted nucleic acid binding protein containing the AN1-type Zn-finger |
| COG3596 | Predicted GTPase |
| COG3607 | Predicted lactoylglutathione lyase |
| COG3608 | Predicted deacylase |
| COG3618 | Predicted metal-dependent hydrolase of the TIM-barrel fold |
| COG3621 | Patatin |
| COG3628 | Phage baseplate assembly protein W |
| COG3631 | Ketosteroid isomerase-related protein |
| COG3641 | Predicted membrane protein, putative toxin regulator |
| COG3654 | Prophage maintenance system killer protein |
| COG3668 | Plasmid stabilization system protein |
| COG3683 | ABC-type uncharacterized transport system, periplasmic component |
| COG3687 | Predicted metal-dependent hydrolase |
| COG3688 | Predicted RNA-binding protein containing a PIN domain |
| COG3694 | ABC-type uncharacterized transport system, permease component |
| COG3700 | Acid phosphatase (class B) |
| COG3726 | Uncharacterized membrane protein affecting hemolysin expression |
| COG3729 | General stress protein |
| COG3740 | Phage head maturation protease |
| COG3769 | Predicted hydrolase (HAD superfamily) |
| COG3772 | Phage-related lysozyme (muraminidase) |
| COG3788 | Uncharacterized relative of glutathione S-transferase, MAPEG superfamily |
| COG3800 | Predicted transcriptional regulator |
| COG3818 | Predicted acetyltransferase, GNAT superfamily |
| COG3822 | ABC-type sugar transport system, auxiliary component |
| COG3845 | ABC-type uncharacterized transport systems, ATPase components |
| COG3858 | Predicted glycosyl hydrolase |
| COG3871 | Uncharacterized stress protein (general stress protein 26) |
| COG3872 | Predicted metal-dependent enzyme |
| COG3889 | Predicted solute binding protein |
| COG3894 | Uncharacterized metal-binding protein |
| COG3895 | Predicted periplasmic protein |
| COG3897 | Predicted methyltransferase |
| COG3899 | Predicted ATPase |
| COG3903 | Predicted ATPase |
| COG3907 | PAP2 (acid phosphatase) superfamily protein |
| COG3910 | Predicted ATPase |
| COG3911 | Predicted ATPase |
| COG3919 | Predicted ATP-grasp enzyme |
| COG3926 | Putative secretion activating protein |
| COG3932 | Uncharacterized ABC-type transport system, permease components |
| COG3940 | Predicted beta-xylosidase |
| COG3941 | Mu-like prophage protein |
| COG3942 | Surface antigen |
| COG3943 | Virulence protein |
| COG3948 | Phage-related baseplate assembly protein |
| COG3950 | Predicted ATP-binding protein involved in virulence |
| COG3953 | SLT domain proteins |
| COG3956 | Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain |
| COG3960 | Glyoxylate carboligase |
| COG3961 | Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes |
| COG3964 | Predicted amidohydrolase |
| COG3968 | Uncharacterized protein related to glutamine synthetase |
| COG3969 | Predicted phosphoadenosine phosphosulfate sulfotransferase |
| COG3970 | Fumarylacetoacetate (FAA) hydrolase family protein |
| COG3972 | Superfamily I DNA and RNA helicases |
| COG3973 | Superfamily I DNA and RNA helicases |
| COG3975 | Predicted protease with the C-terminal PDZ domain |
| COG3979 | Uncharacterized protein contain chitin-binding domain type 3 |
| COG3981 | Predicted acetyltransferase |
| COG4001 | Predicted metal-binding protein |
| COG4002 | Predicted phosphotransacetylase |
| COG4007 | Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase |
| COG4015 | Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family |
| COG4026 | Uncharacterized protein containing TOPRIM domain, potential nuclease |
| COG4028 | Predicted P-loop ATPase/GTPase |
| COG4031 | Predicted metal-binding protein |
| COG4032 | Predicted thiamine-pyrophosphate-binding protein |
| COG4049 | Uncharacterized protein containing archaeal-type C2H2 Zn-finger |
| COG4052 | Uncharacterized protein related to methyl coenzyme M reductase subunit C |
| COG4076 | Predicted RNA methylase |
| COG4085 | Predicted RNA-binding protein, contains TRAM domain |
| COG4087 | Soluble P-type ATPase |
| COG4099 | Predicted peptidase |
| COG4105 | DNA uptake lipoprotein |
| COG4106 | Trans-aconitate methyltransferase |
| COG4110 | Uncharacterized protein involved in stress response |
| COG4111 | Uncharacterized conserved protein |
| COG4112 | Predicted phosphoesterase (MutT family) |
| COG4113 | Predicted nucleic acid-binding protein, contains PIN domain |
| COG4114 | Uncharacterized Fe-S protein |
| COG4119 | Predicted NTP pyrophosphohydrolase |
| COG4120 | ABC-type uncharacterized transport system, permease component |
| COG4122 | Predicted O-methyltransferase |
| COG4123 | Predicted O-methyltransferase |
| COG4128 | Zonula occludens toxin |
| COG4132 | ABC-type uncharacterized transport system, permease component |
| COG4134 | ABC-type uncharacterized transport system, periplasmic component |
| COG4135 | ABC-type uncharacterized transport system, permease component |
| COG4136 | ABC-type uncharacterized transport system, ATPase component |
| COG4137 | ABC-type uncharacterized transport system, permease component |
| COG4146 | Predicted symporter |
| COG4147 | Predicted symporter |
| COG4152 | ABC-type uncharacterized transport system, ATPase component |
| COG4158 | Predicted ABC-type sugar transport system, permease component |
| COG4172 | ABC-type uncharacterized transport system, duplicated ATPase component |
| COG4174 | ABC-type uncharacterized transport system, permease component |
| COG4178 | ABC-type uncharacterized transport system, permease and ATPase components |
| COG4186 | Predicted phosphoesterase or phosphohydrolase |
| COG4188 | Predicted dienelactone hydrolase |
| COG4194 | Predicted membrane protein |
| COG4195 | Phage-related replication protein |
| COG4221 | Short-chain alcohol dehydrogenase of unknown specificity |
| COG4225 | Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins |
| COG4228 | Mu-like prophage DNA circulation protein |
| COG4239 | ABC-type uncharacterized transport system, permease component |
| COG4240 | Predicted kinase |
| COG4245 | Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain |
| COG4248 | Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains |
| COG4249 | Uncharacterized protein containing caspase domain |
| COG4258 | Predicted exporter |
| COG4261 | Predicted acyltransferase |
| COG4262 | Predicted spermidine synthase with an N-terminal membrane domain |
| COG4277 | Predicted DNA-binding protein with the Helix-hairpin-helix motif |
| COG4287 | PhoPQ-activated pathogenicity-related protein |
| COG4310 | Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain |
| COG4321 | Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis |
| COG4324 | Predicted aminopeptidase |
| COG4326 | Sporulation control protein |
| COG4341 | Predicted HD phosphohydrolase |
| COG4373 | Mu-like prophage FluMu protein gp28 |
| COG4379 | Mu-like prophage tail protein gpP |
| COG4385 | Bacteriophage P2-related tail formation protein |
| COG4386 | Mu-like prophage tail sheath protein gpL |
| COG4388 | Mu-like prophage I protein |
| COG4396 | Mu-like prophage host-nuclease inhibitor protein Gam |
| COG4397 | Mu-like prophage major head subunit gpT |
| COG4416 | Mu-like prophage protein Com |
| COG4447 | Uncharacterized protein related to plant photosystem II stability/assembly factor |
| COG4449 | Predicted protease of the Abi (CAAX) family |
| COG4455 | Protein of avirulence locus involved in temperature-dependent protein secretion |
| COG4469 | Competence protein |
| COG4492 | ACT domain-containing protein |
| COG4533 | ABC-type uncharacterized transport system, periplasmic component |
| COG4540 | Phage P2 baseplate assembly protein gpV |
| COG4551 | Predicted protein tyrosine phosphatase |
| COG4552 | Predicted acetyltransferase involved in intracellular survival and related acetyltransferases |
| COG4572 | Putative cation transport regulator |
| COG4574 | Serine protease inhibitor ecotin |
| COG4586 | ABC-type uncharacterized transport system, ATPase component |
| COG4587 | ABC-type uncharacterized transport system, permease component |
| COG4588 | Accessory colonization factor AcfC, contains ABC-type periplasmic domain |
| COG4589 | Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase |
| COG4590 | ABC-type uncharacterized transport system, permease component |
| COG4603 | ABC-type uncharacterized transport system, permease component |
| COG4618 | ABC-type protease/lipase transport system, ATPase and permease components |
| COG4619 | ABC-type uncharacterized transport system, ATPase component |
| COG4624 | Iron only hydrogenase large subunit, C-terminal domain |
| COG4626 | Phage terminase-like protein, large subunit |
| COG4637 | Predicted ATPase |
| COG4638 | Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit |
| COG4639 | Predicted kinase |
| COG4653 | Predicted phage phi-C31 gp36 major capsid-like protein |
| COG4666 | TRAP-type uncharacterized transport system, fused permease components |
| COG4667 | Predicted esterase of the alpha-beta hydrolase superfamily |
| COG4671 | Predicted glycosyl transferase |
| COG4674 | Uncharacterized ABC-type transport system, ATPase component |
| COG4691 | Plasmid stability protein |
| COG4710 | Predicted DNA-binding protein with an HTH domain |
| COG4734 | Antirestriction protein |
| COG4740 | Predicted metalloprotease |
| COG4747 | ACT domain-containing protein |
| COG4756 | Predicted cation transporter |
| COG4757 | Predicted alpha/beta hydrolase |
| COG4768 | Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain |
| COG4783 | Putative Zn-dependent protease, contains TPR repeats |
| COG4784 | Putative Zn-dependent protease |
| COG4785 | Lipoprotein NlpI, contains TPR repeats |
| COG4797 | Predicted regulatory domain of a methyltransferase |
| COG4798 | Predicted methyltransferase |
| COG4801 | Predicted acyltransferase |
| COG4814 | Uncharacterized protein with an alpha/beta hydrolase fold |
| COG4821 | Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain |
| COG4824 | Phage-related holin (Lysis protein) |
| COG4827 | Predicted transporter |
| COG4851 | Protein involved in sex pheromone biosynthesis |
| COG4857 | Predicted kinase |
| COG4867 | Uncharacterized protein with a von Willebrand factor type A (vWA) domain |
| COG4880 | Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats |
| COG4882 | Predicted aminopeptidase, Iap family |
| COG4887 | Uncharacterized metal-binding protein conserved in archaea |
| COG4888 | Uncharacterized Zn ribbon-containing protein |
| COG4889 | Predicted helicase |
| COG4892 | Predicted heme/steroid binding protein |
| COG4900 | Predicted metallopeptidase |
| COG4908 | Uncharacterized protein containing a NRPS condensation (elongation) domain |
| COG4914 | Predicted nucleotidyltransferase |
| COG4915 | 5-bromo-4-chloroindolyl phosphate hydrolysis protein |
| COG4927 | Predicted choloylglycine hydrolase |
| COG4928 | Predicted P-loop ATPase |
| COG4948 | L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily |
| COG4956 | Integral membrane protein (PIN domain superfamily) |
| COG4976 | Predicted methyltransferase (contains TPR repeat) |
| COG4980 | Gas vesicle protein |
| COG4989 | Predicted oxidoreductase |
| COG4996 | Predicted phosphatase |
| COG5003 | Mu-like prophage protein gp37 |
| COG5004 | P2-like prophage tail protein X |
| COG5005 | Mu-like prophage protein gpG |
| COG5006 | Predicted permease, DMT superfamily |
| COG5012 | Predicted cobalamin binding protein |
| COG5014 | Predicted Fe-S oxidoreductase |
| COG5018 | Inhibitor of the KinA pathway to sporulation, predicted exonuclease |
| COG5038 | Ca2+-dependent lipid-binding protein, contains C2 domain |
| COG5048 | FOG: Zn-finger |
| COG5063 | CCCH-type Zn-finger protein |
| COG5083 | Uncharacterized protein involved in plasmid maintenance |
| COG5084 | Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins |
| COG5088 | Rad5p-binding protein |
| COG5091 | Suppressor of G2 allele of skp1 and related proteins |
| COG5109 | Uncharacterized conserved protein, contains RING Zn-finger |
| COG5112 | U1-like Zn-finger-containing protein |
| COG5119 | Uncharacterized protein, contains ParB-like nuclease domain |
| COG5124 | Protein predicted to be involved in meiotic recombination |
| COG5126 | Ca2+-binding protein (EF-Hand superfamily) |
| COG5129 | Nuclear protein with HMG-like acidic region |
| COG5141 | PHD zinc finger-containing protein |
| COG5152 | Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers |
| COG5191 | Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat |
| COG5198 | Protein tyrosine phosphatase-like protein (contains Pro instead of catalytic Arg) |
| COG5209 | Uncharacterized protein involved in cell differentiation/sexual development |
| COG5210 | GTPase-activating protein |
| COG5219 | Uncharacterized conserved protein, contains RING Zn-finger |
| COG5222 | Uncharacterized conserved protein, contains RING Zn-finger |
| COG5236 | Uncharacterized conserved protein, contains RING Zn-finger |
| COG5252 | Uncharacterized conserved protein, contains CCCH-type Zn-finger protein |
| COG5258 | GTPase |
| COG5263 | FOG: Glucan-binding domain (YG repeat) |
| COG5271 | AAA ATPase containing von Willebrand factor type A (vWA) domain |
| COG5273 | Uncharacterized protein containing DHHC-type Zn finger |
| COG5275 | BRCT domain type II |
| COG5301 | Phage-related tail fibre protein |
| COG5302 | Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid |
| COG5307 | SEC7 domain proteins |
| COG5322 | Predicted dehydrogenase |
| COG5342 | Invasion protein B, involved in pathogenesis |
| COG5350 | Predicted protein tyrosine phosphatase |
| COG5354 | Uncharacterized protein, contains Trp-Asp (WD) repeat |
| COG5362 | Phage-related terminase |
| COG5366 | Protein involved in propagation of M2 dsRNA satellite of L-A virus |
| COG5378 | Predicted nucleotide-binding protein |
| COG5391 | Phox homology (PX) domain protein |
| COG5401 | Spore germination protein |
| COG5415 | Predicted integral membrane metal-binding protein |
| COG5485 | Predicted ester cyclase |
| COG5496 | Predicted thioesterase |
| COG5511 | Bacteriophage capsid protein |
| COG5512 | Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives |
| COG5516 | Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding |
| COG5518 | Bacteriophage capsid portal protein |
| COG5524 | Bacteriorhodopsin |
| COG5525 | Bacteriophage tail assembly protein |
| COG5529 | Pyocin large subunit |
| COG5544 | Predicted periplasmic lipoprotein |
| COG5545 | Predicted P-loop ATPase and inactivated derivatives |
| COG5553 | Predicted metal-dependent enzyme of the double-stranded beta helix superfamily |
| COG5562 | Phage envelope protein |
| COG5564 | Predicted TIM-barrel enzyme, possibly a dioxygenase |
| COG5565 | Bacteriophage terminase large (ATPase) subunit and inactivated derivatives |
| COG5573 | Predicted nucleic-acid-binding protein, contains PIN domain |
| COG5595 | Zn-ribbon-containing, possibly nucleic-acid-binding protein |
| COG5610 | Predicted hydrolase (HAD superfamily) |
| COG5611 | Predicted nucleic-acid-binding protein, contains PIN domain |
| COG5614 | Bacteriophage head-tail adaptor |
| COG5618 | Predicted periplasmic lipoprotein |
| COG5621 | Predicted secreted hydrolase |
| COG5628 | Predicted acetyltransferase |
| COG5633 | Predicted periplasmic lipoprotein |
| COG5643 | Protein containing a metal-binding domain shared with formylmethanofuran dehydrogenase subunit E |
| COG5645 | Predicted periplasmic lipoprotein |
