oxidized pyrimidine base lesion DNA N-glycosylase activity
id: GO:0000703
name: oxidized pyrimidine base lesion DNA N-glycosylase activity
namespace: molecular_function
type: go
obsolete: False
Description: Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
Child Functions
| id | name |
|---|---|
| GO:0034042 | 5-formyluracil DNA N-glycosylase activity |
| GO:0034043 | 5-hydroxymethyluracil DNA N-glycosylase activity |
Parent Functions
| id | name |
|---|---|
| GO:0000702 | oxidized base lesion DNA N-glycosylase activity |
| GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity |
