marginal zone B cell differentiation
id: GO:0002315
name: marginal zone B cell differentiation
namespace: biological_process
type: go
obsolete: False
Description: The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
Parent Functions
id | name |
---|---|
GO:0002313 | mature B cell differentiation involved in immune response |