alkylbase DNA N-glycosylase activity

id: GO:0003905
name: alkylbase DNA N-glycosylase activity
namespace: molecular_function
type: go
obsolete: False

Description: Catalysis of the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine. Enzymes with this activity recognize and remove alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site.

Child Functions

GO:0008725DNA-3-methyladenine glycosylase I activity
GO:0043733DNA-3-methyladenine glycosylase III activity
GO:0043736DNA-3-methyladenine glycosylase IV activity
GO:0043916DNA-7-methylguanine glycosylase activity

Parent Functions

GO:0019104DNA N-glycosylase activity