eukaryotic translation initiation factor 3 complex

id: GO:0005852
name: eukaryotic translation initiation factor 3 complex
namespace: cellular_component
type: go
obsolete: False

Description: A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.

Child Functions

idname
GO:0071540eukaryotic translation initiation factor 3 complex, eIF3e
GO:0071541eukaryotic translation initiation factor 3 complex, eIF3m

Parent Functions

idname
GO:0043234protein complex
GO:0044444cytoplasmic part