DNA topoisomerase (ATP-hydrolyzing) inhibitor activity

id: GO:0008657
name: DNA topoisomerase (ATP-hydrolyzing) inhibitor activity
namespace: molecular_function
type: go
obsolete: False

Description: Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.

Parent Functions