negative cofactor 2 complex

id: GO:0017054
name: negative cofactor 2 complex
namespace: cellular_component
type: go
obsolete: False

Description: A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.

Parent Functions