Notch receptor processing, ligand-dependent

id: GO:0035333
name: Notch receptor processing, ligand-dependent
namespace: biological_process
type: go
obsolete: False

Description: The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).

Parent Functions