regulation of molecular function, epigenetic
id: GO:0040030
name: regulation of molecular function, epigenetic
namespace: biological_process
type: go
obsolete: False
Description: Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.
Child Functions
id | name |
---|---|
GO:0045857 | negative regulation of molecular function, epigenetic |
GO:0045858 | positive regulation of molecular function, epigenetic |
Parent Functions
id | name |
---|---|
GO:0065009 | regulation of molecular function |