isotype switching
id: GO:0045190
name: isotype switching
namespace: biological_process
type: go
obsolete: False
Description: The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
Child Functions
| id | name |
|---|---|
| GO:0048289 | isotype switching to IgE isotypes |
| GO:0048290 | isotype switching to IgA isotypes |
| GO:0048291 | isotype switching to IgG isotypes |
| GO:0048292 | isotype switching to IgD isotypes |
Parent Functions
| id | name |
|---|---|
| GO:0002204 | somatic recombination of immunoglobulin genes involved in immune response |
| GO:0002312 | B cell activation involved in immune response |
