BRCA1-C complex
id: GO:0070533
name: BRCA1-C complex
namespace: cellular_component
type: go
obsolete: False
Description: A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint.
Parent Functions
id | name |
---|---|
GO:0043234 | protein complex |
GO:0044428 | nuclear part |