NF-kappaB complex
id: GO:0071159
name: NF-kappaB complex
namespace: cellular_component
type: go
obsolete: False
Description: A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.
Child Functions
id | name |
---|---|
GO:0035525 | NF-kappaB p50/p65 complex |
Parent Functions
id | name |
---|---|
GO:0043234 | protein complex |
GO:0044424 | intracellular part |