| COG0001 | Glutamate-1-semialdehyde aminotransferase |
| COG0007 | Uroporphyrinogen-III methylase |
| COG0028 | Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] |
| COG0029 | Aspartate oxidase |
| COG0043 | 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases |
| COG0054 | Riboflavin synthase beta-chain |
| COG0059 | Ketol-acid reductoisomerase |
| COG0095 | Lipoate-protein ligase A |
| COG0108 | 3,4-dihydroxy-2-butanone 4-phosphate synthase |
| COG0111 | Phosphoglycerate dehydrogenase and related dehydrogenases |
| COG0113 | Delta-aminolevulinic acid dehydratase |
| COG0115 | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase |
| COG0117 | Pyrimidine deaminase |
| COG0132 | Dethiobiotin synthetase |
| COG0142 | Geranylgeranyl pyrophosphate synthase |
| COG0147 | Anthranilate/para-aminobenzoate synthases component I |
| COG0156 | 7-keto-8-aminopelargonate synthetase and related enzymes |
| COG0157 | Nicotinate-nucleotide pyrophosphorylase |
| COG0161 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase |
| COG0163 | 3-polyprenyl-4-hydroxybenzoate decarboxylase |
| COG0171 | NAD synthase |
| COG0175 | 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes |
| COG0181 | Porphobilinogen deaminase |
| COG0189 | Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) |
| COG0190 | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase |
| COG0192 | S-adenosylmethionine synthetase |
| COG0196 | FAD synthase |
| COG0212 | 5-formyltetrahydrofolate cyclo-ligase |
| COG0214 | Pyridoxine biosynthesis enzyme |
| COG0237 | Dephospho-CoA kinase |
| COG0259 | Pyridoxamine-phosphate oxidase |
| COG0262 | Dihydrofolate reductase |
| COG0276 | Protoheme ferro-lyase (ferrochelatase) |
| COG0285 | Folylpolyglutamate synthase |
| COG0294 | Dihydropteroate synthase and related enzymes |
| COG0301 | Thiamine biosynthesis ATP pyrophosphatase |
| COG0302 | GTP cyclohydrolase I |
| COG0303 | Molybdopterin biosynthesis enzyme |
| COG0307 | Riboflavin synthase alpha chain |
| COG0311 | Predicted glutamine amidotransferase involved in pyridoxine biosynthesis |
| COG0314 | Molybdopterin converting factor, large subunit |
| COG0315 | Molybdenum cofactor biosynthesis enzyme |
| COG0320 | Lipoate synthase |
| COG0321 | Lipoate-protein ligase B |
| COG0340 | Biotin-(acetyl-CoA carboxylase) ligase |
| COG0351 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase |
| COG0352 | Thiamine monophosphate synthase |
| COG0368 | Cobalamin-5-phosphate synthase |
| COG0373 | Glutamyl-tRNA reductase |
| COG0379 | Quinolinate synthase |
| COG0382 | 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases |
| COG0407 | Uroporphyrinogen-III decarboxylase |
| COG0408 | Coproporphyrinogen III oxidase |
| COG0413 | Ketopantoate hydroxymethyltransferase |
| COG0414 | Panthothenate synthetase |
| COG0422 | Thiamine biosynthesis protein ThiC |
| COG0447 | Dihydroxynaphthoic acid synthase |
| COG0452 | Phosphopantothenoylcysteine synthetase/decarboxylase |
| COG0476 | Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 |
| COG0499 | S-adenosylhomocysteine hydrolase |
| COG0502 | Biotin synthase and related enzymes |
| COG0512 | Anthranilate/para-aminobenzoate synthases component II |
| COG0521 | Molybdopterin biosynthesis enzymes |
| COG0543 | 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases |
| COG0611 | Thiamine monophosphate kinase |
| COG0635 | Coproporphyrinogen III oxidase and related Fe-S oxidoreductases |
| COG0654 | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases |
| COG0669 | Phosphopantetheine adenylyltransferase |
| COG0684 | Demethylmenaquinone methyltransferase |
| COG0720 | 6-pyruvoyl-tetrahydropterin synthase |
| COG0746 | Molybdopterin-guanine dinucleotide biosynthesis protein A |
| COG0801 | 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase |
| COG0807 | GTP cyclohydrolase II |
| COG0853 | Aspartate 1-decarboxylase |
| COG0854 | Pyridoxal phosphate biosynthesis protein |
| COG1010 | Precorrin-3B methylase |
| COG1052 | Lactate dehydrogenase and related dehydrogenases |
| COG1056 | Nicotinamide mononucleotide adenylyltransferase |
| COG1057 | Nicotinic acid mononucleotide adenylyltransferase |
| COG1060 | Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes |
| COG1072 | Panthothenate kinase |
| COG1120 | ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components |
| COG1154 | Deoxyxylulose-5-phosphate synthase |
| COG1165 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase |
| COG1169 | Isochorismate synthase |
| COG1179 | Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 |
| COG1232 | Protoporphyrinogen oxidase |
| COG1239 | Mg-chelatase subunit ChlI |
| COG1240 | Mg-chelatase subunit ChlD |
| COG1270 | Cobalamin biosynthesis protein CobD/CbiB |
| COG1339 | Transcriptional regulator of a riboflavin/FAD biosynthetic operon |
| COG1424 | Pimeloyl-CoA synthetase |
| COG1429 | Cobalamin biosynthesis protein CobN and related Mg-chelatases |
| COG1441 | O-succinylbenzoate synthase |
| COG1477 | Membrane-associated lipoprotein involved in thiamine biosynthesis |
| COG1488 | Nicotinic acid phosphoribosyltransferase |
| COG1492 | Cobyric acid synthase |
| COG1539 | Dihydroneopterin aldolase |
| COG1541 | Coenzyme F390 synthetase |
| COG1564 | Thiamine pyrophosphokinase |
| COG1575 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase |
| COG1587 | Uroporphyrinogen-III synthase |
| COG1635 | Flavoprotein involved in thiazole biosynthesis |
| COG1648 | Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) |
| COG1685 | Archaeal shikimate kinase |
| COG1713 | Predicted HD superfamily hydrolase involved in NAD metabolism |
| COG1731 | Archaeal riboflavin synthase |
| COG1763 | Molybdopterin-guanine dinucleotide biosynthesis protein |
| COG1767 | Triphosphoribosyl-dephospho-CoA synthetase |
| COG1797 | Cobyrinic acid a,c-diamide synthase |
| COG1893 | Ketopantoate reductase |
| COG1903 | Cobalamin biosynthesis protein CbiD |
| COG1932 | Phosphoserine aminotransferase |
| COG1953 | Cytosine/uracil/thiamine/allantoin permeases |
| COG1962 | Tetrahydromethanopterin S-methyltransferase, subunit H |
| COG1977 | Molybdopterin converting factor, small subunit |
| COG1985 | Pyrimidine reductase, riboflavin biosynthesis |
| COG1995 | Pyridoxal phosphate biosynthesis protein |
| COG2022 | Uncharacterized enzyme of thiazole biosynthesis |
| COG2038 | NaMN:DMB phosphoribosyltransferase |
| COG2045 | Phosphosulfolactate phosphohydrolase and related enzymes |
| COG2073 | Cobalamin biosynthesis protein CbiG |
| COG2082 | Precorrin isomerase |
| COG2087 | Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase |
| COG2091 | Phosphopantetheinyl transferase |
| COG2099 | Precorrin-6x reductase |
| COG2104 | Sulfur transfer protein involved in thiamine biosynthesis |
| COG2109 | ATP:corrinoid adenosyltransferase |
| COG2145 | Hydroxyethylthiazole kinase, sugar kinase family |
| COG2154 | Pterin-4a-carbinolamine dehydratase |
| COG2226 | Methylase involved in ubiquinone/menaquinone biosynthesis |
| COG2227 | 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase |
| COG2240 | Pyridoxal/pyridoxine/pyridoxamine kinase |
| COG2241 | Precorrin-6B methylase 1 |
| COG2242 | Precorrin-6B methylase 2 |
| COG2243 | Precorrin-2 methylase |
| COG2266 | GTP:adenosylcobinamide-phosphate guanylyltransferase |
| COG2875 | Precorrin-4 methylase |
| COG2896 | Molybdenum cofactor biosynthesis enzyme |
| COG2918 | Gamma-glutamylcysteine synthetase |
| COG2941 | Ubiquinone biosynthesis protein COQ7 |
| COG2959 | Uncharacterized enzyme of heme biosynthesis |
| COG2978 | Putative p-aminobenzoyl-glutamate transporter |
| COG2998 | ABC-type tungstate transport system, permease component |
| COG3071 | Uncharacterized enzyme of heme biosynthesis |
| COG3161 | 4-hydroxybenzoate synthetase (chorismate lyase) |
| COG3172 | Predicted ATPase/kinase involved in NAD metabolism |
| COG3201 | Nicotinamide mononucleotide transporter |
| COG3252 | Methenyltetrahydromethanopterin cyclohydrolase |
| COG3572 | Gamma-glutamylcysteine synthetase |
| COG3585 | Molybdopterin-binding protein |
| COG3697 | Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) |
| COG3840 | ABC-type thiamine transport system, ATPase component |
| COG3961 | Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes |
| COG4054 | Methyl coenzyme M reductase, beta subunit |
| COG4055 | Methyl coenzyme M reductase, subunit D |
| COG4056 | Methyl coenzyme M reductase, subunit C |
| COG4057 | Methyl coenzyme M reductase, gamma subunit |
| COG4058 | Methyl coenzyme M reductase, alpha subunit |
| COG4059 | Tetrahydromethanopterin S-methyltransferase, subunit E |
| COG4060 | Tetrahydromethanopterin S-methyltransferase, subunit D |
| COG4061 | Tetrahydromethanopterin S-methyltransferase, subunit C |
| COG4062 | Tetrahydromethanopterin S-methyltransferase, subunit B |
| COG4063 | Tetrahydromethanopterin S-methyltransferase, subunit A |
| COG4064 | Tetrahydromethanopterin S-methyltransferase, subunit G |
| COG4138 | ABC-type cobalamin transport system, ATPase component |
| COG4139 | ABC-type cobalamin transport system, permease component |
| COG4143 | ABC-type thiamine transport system, periplasmic component |
| COG4145 | Na+/panthothenate symporter |
| COG4206 | Outer membrane cobalamin receptor protein |
| COG4218 | Tetrahydromethanopterin S-methyltransferase, subunit F |
| COG4547 | Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) |
| COG4635 | Flavodoxin |
| COG4662 | ABC-type tungstate transport system, periplasmic component |
| COG4822 | Cobalamin biosynthesis protein CbiK, Co2+ chelatase |
| COG5031 | Uncharacterized protein involved in ubiquinone biosynthesis |
| COG5146 | Pantothenate kinase, acetyl-CoA regulated |
| COG5424 | Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C |
| COG5598 | Trimethylamine:corrinoid methyltransferase |
