TIGRFAMs

TIGRFAMs is a system for protein sequence classification designed to support automated annotation of (mostly prokaryotic) proteins.

• Hypothetical proteins
  • Domain
  • Conserved
• Central intermediary metabolism
  • Nitrogen fixation
  • Other
  • One-carbon metabolism
  • Amino sugars
  • Polyamine biosynthesis
  • Phosphorus compounds
  • Sulfur metabolism
  • Nitrogen metabolism
• Energy metabolism
  • Aerobic
  • Electron transport
  • Pyruvate dehydrogenase
  • Glycolysis/gluconeogenesis
  • Photosynthesis
  • ATP-proton motive force interconversion
  • Amino acids and amines
  • Anaerobic
  • Pentose phosphate pathway
  • Entner-Doudoroff
  • Biosynthesis and degradation of polysaccharides
  • TCA cycle
  • Fermentation
  • Chemoautotrophy
  • Sugars
  • Methanogenesis
  • Other
• Fatty acid and phospholipid metabolism
  • Other
  • Biosynthesis
  • Degradation
• Purines, pyrimidines, nucleosides, and nucleotides
  • Purine ribonucleotide biosynthesis
  • Other
  • Pyrimidine ribonucleotide biosynthesis
  • Nucleotide and nucleoside interconversions
  • Salvage of nucleosides and nucleotides
  • 2'-Deoxyribonucleotide metabolism
• Regulatory functions
  • Other
  • RNA interactions
  • Small molecule interactions
  • Protein interactions
  • DNA interactions
• DNA metabolism
  • DNA replication, recombination, and repair
  • Restriction/modification
  • Other
  • Degradation of DNA
  • Chromosome-associated proteins
• Transcription
  • Degradation of RNA
  • DNA-dependent RNA polymerase
  • Transcription factors
  • RNA processing
  • Other
• Protein synthesis
  • tRNA and rRNA base modification
  • Ribosomal proteins: synthesis and modification
  • Other
  • tRNA aminoacylation
  • Translation factors
• Protein fate
  • Degradation of proteins, peptides, and glycopeptides
  • Protein and peptide secretion and trafficking
  • Protein modification and repair
  • Protein folding and stabilization
  • Other
• Transport and binding proteins
  • Unknown substrate
  • Anions
  • Amino acids, peptides and amines
  • Carbohydrates, organic alcohols, and acids
  • Cations and iron carrying compounds
  • Other
  • Porins
  • Nucleosides, purines and pyrimidines
• Cellular processes
  • Sporulation and germination
  • Conjugation
  • Detoxification
  • Adaptations to atypical conditions
  • Pathogenesis
  • Chemotaxis and motility
  • Other
  • Cell division
  • Toxin production and resistance
  • DNA transformation
  • Biosynthesis of natural products
• Mobile and extrachromosomal element functions
  • Plasmid functions
  • Prophage functions
  • Transposon functions
  • Other
• Unknown function
  • General
  • Enzymes of unknown specificity
• Amino acid biosynthesis
  • Other
  • Pyruvate family
  • Aspartate family
  • Histidine family
  • Aromatic amino acid family
  • Glutamate family
  • Serine family
• Biosynthesis of cofactors, prosthetic groups, and carriers
  • Glutathione and analogs
  • Biotin
  • Thiamine
  • Riboflavin, FMN, and FAD
  • Pyridoxine
  • Heme, porphyrin, and cobalamin
  • Menaquinone and ubiquinone
  • Chlorophyll and bacteriochlorphyll
  • Other
  • Pantothenate and coenzyme A
  • Molybdopterin
  • Lipoate
  • Folic acid
  • Pyridine nucleotides
• Unclassified
  • Role category not yet assigned
• Signal transduction
  • PTS
  • Other
  • Two-component systems
• Cell envelope
  • Other
  • Biosynthesis and degradation of murein sacculus and peptidoglycan
  • Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
  • Surface structures

All functional systems