Jak2 Janus kinase 2 (16452)

Symbol Product Feature Type Strand Chr
16452 Jak2 Janus kinase 2 protein-coding 19
Synonyms
Fd17
GO ID Category Definition Evidence
  • nucleotide binding
  • activation of MAPKK activity
  • immune system process
  • protein kinase activity
  • protein tyrosine kinase activity
  • non-membrane spanning protein tyrosine kinase activity
  • receptor binding
  • growth hormone receptor binding
  • interleukin-12 receptor binding
  • protein binding
  • ATP binding
  • intracellular
  • nucleus
  • cytoplasm
  • cytosol
  • cytoskeleton
  • caveola
  • protein phosphorylation
  • activation of cysteine-type endopeptidase activity involved in apoptotic process
  • response to oxidative stress
  • signal transduction
  • enzyme linked receptor protein signaling pathway
  • G-protein coupled receptor signaling pathway
  • positive regulation of cytosolic calcium ion concentration
  • JAK-STAT cascade
  • tyrosine phosphorylation of STAT protein
  • STAT protein import into nucleus
  • protein C-terminus binding
  • positive regulation of cell proliferation
  • negative regulation of cell proliferation
  • intrinsic apoptotic signaling pathway in response to oxidative stress
  • hormone-mediated signaling pathway
  • positive regulation of cell-substrate adhesion
  • positive regulation of phosphatidylinositol 3-kinase signaling
  • membrane
  • kinase activity
  • phosphorylation
  • nuclear matrix
  • chromatin modification
  • transferase activity
  • transferase activity, transferring phosphorus-containing groups
  • peptidyl-tyrosine phosphorylation
  • cytokine-mediated signaling pathway
  • protein kinase binding
  • heme binding
  • negative regulation of cell-cell adhesion
  • myeloid cell differentiation
  • cell differentiation
  • erythrocyte differentiation
  • positive regulation of cell migration
  • axon regeneration
  • type 1 angiotensin receptor binding
  • mineralocorticoid receptor signaling pathway
  • positive regulation of insulin secretion
  • response to lipopolysaccharide
  • positive regulation of phosphoprotein phosphatase activity
  • positive regulation of interleukin-1 beta production
  • positive regulation of tumor necrosis factor production
  • acetylcholine receptor binding
  • positive regulation of protein import into nucleus, translocation
  • response to hydroperoxide
  • tumor necrosis factor-mediated signaling pathway
  • host programmed cell death induced by symbiont
  • response to tumor necrosis factor
  • histone kinase activity (H3-Y41 specific)
  • histone H3-Y41 phosphorylation
  • intracellular signal transduction
  • interleukin-12-mediated signaling pathway
  • SH2 domain binding
  • histone binding
  • tyrosine phosphorylation of Stat3 protein
  • tyrosine phosphorylation of Stat5 protein
  • tyrosine phosphorylation of Stat1 protein
  • positive regulation of tyrosine phosphorylation of Stat3 protein
  • positive regulation of tyrosine phosphorylation of Stat5 protein
  • activation of JAK2 kinase activity
  • positive regulation of apoptotic process
  • negative regulation of apoptotic process
  • positive regulation of DNA binding
  • negative regulation of DNA binding
  • negative regulation of neuron apoptotic process
  • phosphatidylinositol 3-kinase binding
  • insulin receptor substrate binding
  • innate immune response
  • membrane raft
  • positive regulation of nitric oxide biosynthetic process
  • positive regulation of cell differentiation
  • negative regulation of heart contraction
  • response to antibiotic
  • protein autophosphorylation
  • platelet-derived growth factor receptor signaling pathway
  • regulation of inflammatory response
  • positive regulation of inflammatory response
  • positive regulation of peptidyl-tyrosine phosphorylation
  • positive regulation of cell activation
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • peptide hormone receptor binding
  • positive regulation of nitric-oxide synthase biosynthetic process
  • interferon-gamma-mediated signaling pathway
  • growth hormone receptor signaling pathway
  • JAK-STAT cascade involved in growth hormone signaling pathway
  • positive regulation of growth hormone receptor signaling pathway
  • mammary gland epithelium development
  • response to interleukin-12
  • response to granulocyte macrophage colony-stimulating factor
  • extrinsic apoptotic signaling pathway
  • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
  • positive regulation of apoptotic signaling pathway
Motif 1 Motif 2 Residual
PITA_41 |
Residual: 
0.17
0.17
PITA_53 |
Residual: 
0.08
0.08
TargetScan_207 |
Residual: 
0.14
0.14
TargetScan_220 |
Residual: 
0.30
0.30
TargetScan_30 |
Residual: 
1.60
1.60
TargetScan_64 |
Residual: 
0.15
0.15
Displaying 1 - 6 of 6
Entrez ID STRINGS Network
STRING
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