SRP-dependent cotranslational protein targeting to membrane

The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
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Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1)
Signal recognition particle, subunit Ffh SRP54 (TC 3.A.5.1.1)