Rv1344 Acyl carrier protein MbtL


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1344 mbtL Acyl carrier protein MbtL CDS 1508968 1509288 + 321 106 FALSE

Rv1344 (Acyl carrier protein MbtL) is predicted to be co-regulated in modules bicluster_0446 with residual 0.47 and bicluster_0502 with residual 0.52.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 1,700.00 and 5,500.00 for bicluster_0446 and 0.00 and 1.20 for bicluster_0502 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

BASS Score Distance to Tuberculist Start Codon Internal TSS New Internal UTR Re-Annotated Start Tuberculist Annotated Start
-0.698 108 1509076 -42 1509034 1508968
Last update: 10/16/2017 - 11:16
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-14792 MT1385 1680
Product (LegacyBRC) Product (RefSeq)
Acyl carrier protein mbtL acyl carrier protein
Operon # Operon
905 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608484 NP_215860.1 Run

ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process

ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process

Interacting selectively with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis.
GO Category: 
Total items in this category:  

protein binding

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.620000 1.28

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: