Rv1602 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1602 hisH Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) CDS 1802664 1803284 + 621 206 FALSE

Rv1602 (Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)) is predicted to be co-regulated in modules bicluster_0135 with residual 0.54 and bicluster_0460 with residual 0.59.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 3.10 and 2,200.00 for bicluster_0135 and 55.00 and 160.00 for bicluster_0460 respectively.

These modules are enriched for following go terms: small molecule biosynthetic process, single-organism biosynthetic process, aromatic compound biosynthetic process, heterocycle biosynthetic process, organic cyclic compound biosynthetic pro... branched-chain amino acid metabolic proc..., translation, acetolactate synthase activity, anion transmembrane-transporting ATPase ..., structural constituent of ribosome.

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Imidazole glycerol phosphate synthase subunit hisH imidazole glycerol phosphate synthase subunit HisH
Operon # Operon
1054 - - - - - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Pentosyltransferases. Purine metabolism, Butirosin and neomycin biosynthesis
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Histidine metabolism

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Metabolic pathways

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Biosynthesis of secondary metabolites

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608740 NP_216118.1 Run

catalytic activity

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO Category: 
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The increase in size or mass of an entire organism, a part of an organism or a cell.
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No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: