Rv1820 COG0028: Thiamine pyrophosphate-requiring enzymes


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1820 ilvG COG0028: Thiamine pyrophosphate-requiring enzymes CDS 2064799 2066442 + 1 644 547 FALSE

Rv1820 (COG0028: Thiamine pyrophosphate-requiring enzymes) is predicted to be co-regulated in modules bicluster_0049 with residual 0.59 and bicluster_0411 with residual 0.41.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.01 for bicluster_0049 and 0.02 and 36.00 for bicluster_0411 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Probable acetolactate synthase
Operon # Operon
1197 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Valine, leucine and isoleucine biosynthesis

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Butanoate metabolism

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C5-Branched dibasic acid metabolism

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Pantothenate and CoA biosynthesis

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Metabolic pathways

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Biosynthesis of secondary metabolites

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608957 NP_216336.1 Run
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.000000 0.39

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: