Rv1844c 6-phosphogluconate dehydrogenase, decarboxylating (EC


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1844c gnd1 6-phosphogluconate dehydrogenase, decarboxylating (EC CDS 2093731 2095188 - 1 458 485 FALSE

Rv1844c (6-phosphogluconate dehydrogenase, decarboxylating (EC is predicted to be co-regulated in modules bicluster_0289 with residual 0.53 and bicluster_0414 with residual 0.45.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.03 for bicluster_0289 and 65.00 and 550.00 for bicluster_0414 respectively.

These modules are enriched for following go terms: oxidoreductase activity, acting on the C..., oxidoreductase activity, acting on CH-OH... .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
6-phosphogluconate dehydrogenase decarboxylating 6-phosphogluconate dehydrogenase
Operon # Operon
1211 - - -
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Pentose phosphate pathway

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Glutathione metabolism

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Metabolic pathways

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Biosynthesis of secondary metabolites

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Microbial metabolism in diverse environments

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
57116925 YP_177848.1 Run

phosphogluconate dehydrogenase (decarboxylating) activity

phosphogluconate dehydrogenase (decarboxylating) activity

Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.980000 3.20

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: