Rv2231c L-threonine 3-O-phosphate decarboxylase (EC


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2231c cobC L-threonine 3-O-phosphate decarboxylase (EC CDS 2504605 2505699 - 1 095 364 FALSE

Rv2231c (L-threonine 3-O-phosphate decarboxylase (EC is predicted to be co-regulated in modules bicluster_0188 with residual 0.59 and bicluster_0212 with residual 0.55.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 540.00 and 1,200.00 for bicluster_0188 and 0.00 and 0.00 for bicluster_0212 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Uncharacterized aminotransferase Rv2231c_MT2290
Operon # Operon
1466 - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Threonine-phosphate decarboxylase Porphyrin and chlorophyll metabolism
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15609368 NP_216747.1 Run

threonine-phosphate decarboxylase activity

threonine-phosphate decarboxylase activity

Catalysis of the reaction: O-phospho-L-threonine + H(+) = (R)-1-aminopropan-2-yl phosphate + CO(2).
GO Category: 
Total items in this category:  



The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.010000 0.72

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: