Rv2238c Alkyl hydroperoxide reductase subunit C-like protein


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2238c ahpE Alkyl hydroperoxide reductase subunit C-like protein CDS 2510715 2511176 - 462 153 FALSE

Rv2238c (Alkyl hydroperoxide reductase subunit C-like protein) is predicted to be co-regulated in modules bicluster_0020 with residual 0.58 and bicluster_0255 with residual 0.52.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 7.00 and 27,000.00 for bicluster_0020 and 0.00 and 3.80 for bicluster_0255 respectively.

These modules are enriched for following go terms: NADP binding .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Putative peroxiredoxin Rv2238c_MT2298 peroxiredoxin AhpE
Operon # Operon
1470 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15609375 NP_216754.1 Run

peroxidase activity

peroxidase activity

Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
GO Category: 
Total items in this category:  

protein homodimerization activity

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.
GO Category: 
Total items in this category:  

protein homooligomerization

protein homooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.990000 1.42

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: