Rv2584c Adenine phosphoribosyltransferase (EC


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2584c apt Adenine phosphoribosyltransferase (EC CDS 2910229 2910900 - 672 223 FALSE

Rv2584c (Adenine phosphoribosyltransferase (EC is predicted to be co-regulated in modules bicluster_0301 with residual 0.61 and bicluster_0501 with residual 0.59.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 4.40 for bicluster_0301 and 14.00 and 11,000.00 for bicluster_0501 respectively.

These modules are enriched for following go terms: divalent metal ion transport, divalent inorganic cation transport, transition metal ion transport, divalent inorganic cation transmembrane ... .

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Distance to Tuberculist Start Codon Internal TSS New Internal UTR New Primary UTR Primary TSS Re-Annotated Start Tuberculist Annotated Start
-0.579 7 2910893 149 180 2910924 2910744 2910900
Product (LegacyBRC) Product (RefSeq)
Adenine phosphoribosyltransferase adenine phosphoribosyltransferase
Operon # Operon
1697 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Adenine phosphoribosyltransferase Purine metabolism
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Purine metabolism

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Metabolic pathways

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15609721 NP_217100.1 Run

adenine phosphoribosyltransferase activity

adenine phosphoribosyltransferase activity

Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
GO Category: 
Total items in this category:  

plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.000000 0.42

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: