Rv2589 Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2589 gabT Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC CDS 2916360 2917709 + 1 350 449 FALSE

Rv2589 (Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC is predicted to be co-regulated in modules bicluster_0097 with residual 0.50 and bicluster_0482 with residual 0.61.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.37 for bicluster_0097 and 0.02 and 0.93 for bicluster_0482 respectively.

These modules are enriched for following go terms: monovalent inorganic cation transmembran..., inorganic cation transmembrane transport... cellular macromolecule biosynthetic proc..., macromolecule biosynthetic process, macromolecule metabolic process, cytoplasm.

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 13:57
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-18723 MT2666 2902
Product (LegacyBRC) Product (RefSeq)
4-aminobutyrate aminotransferase 4-aminobutyrate aminotransferase
Operon # Operon
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Alanine, aspartate and glutamate metabolism

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Valine, leucine and isoleucine degradation

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beta-Alanine metabolism

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Propanoate metabolism

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Butanoate metabolism

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Metabolic pathways

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15609726 NP_217105.1 Run

plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.160000 1.10

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: