Rv2788 Mn-dependent transcriptional regulator MntR


Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2788 sirR Mn-dependent transcriptional regulator MntR CDS 3096959 3097645 + 687 228 TRUE

Rv2788 (Mn-dependent transcriptional regulator MntR) is predicted to be co-regulated in modules bicluster_0229 with residual 0.54 and bicluster_0262 with residual 0.39.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 170.00 and 860.00 for bicluster_0229 and 1,700.00 and 2,700.00 for bicluster_0262 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 11/20/2020 - 12:12
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-18157 MT2858 1607
Displaying 1 - 3 of 3
Gene Target Differential Expression Distance Expression pvalue Type
Phosphoheptose isomerase (EC 5.3.1.-)
No -57 -0.22 0.548784 CDS
Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC
Repressed 38 -1.63 0.000000308 Primary.TSS
FIG037441: Conserved transmembrane protein
Induced -72 1.23 0.00262476 Primary.TSS
Product (LegacyBRC) Product (RefSeq)
Operon # Operon
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15609925 NP_217304.1 Run

iron ion binding

iron ion binding

Interacting selectively and non-covalently with iron (Fe) ions.
GO Category: 
Total items in this category:  

sequence-specific DNA binding transcription factor activity

sequence-specific DNA binding transcription factor activity

Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
GO Category: 
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
BioProject Accession GEO Series References Repository Sample Method Sample Type
PRJNA254351 GSM1426874 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426875 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426876 GSE59086 25232098 GEO Tiling Array RNA
Experiment UCSC Genome Browser
Rv2788_B626 UCSC Browser Tracks

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.810000 1.51

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated: 0.31313
p-value INH: 0.988908
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D0U 27 0 0.00 12.03 U
D3I 3 3 3.83 12.67 I
D3U 3 3 3.83 11.80 U
D5I 9 5 6.00 13.17 I
D5U 17 5 6.00 12.91 U
D7I 18 7 8.14 11.49 I
D7U 19 7 8.14 11.70 U
D14I 4 14 15.63 12.00 I
D14U 4 14 15.63 11.98 U
D17I 3 17 19.15 11.34 I
D17U 3 17 19.15 11.57 U
D21I 4 21 23.23 11.39 I
D21U 4 21 23.23 11.75 U
D24I 3 24 26.60 10.54 I
D24U 3 24 26.60 11.38 U
D28I 4 28 30.61 10.70 I
D28U 4 28 30.61 11.43 U