Rv3552 Putative CoA-transferase subunit beta Rv3552/MT3656 (EC 2.8.3.-)


Product Feature Type Start End Strand Length AA Length is TF
Rv3552 Putative CoA-transferase subunit beta Rv3552/MT3656 (EC 2.8.3.-) CDS 3990771 3991523 + 753 250 FALSE

Rv3552 (Putative CoA-transferase subunit beta Rv3552/MT3656 (EC 2.8.3.-)) is predicted to be co-regulated in modules bicluster_0009 with residual 0.64 and bicluster_0152 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 6,300.00 and 21,000.00 for bicluster_0009 and 0.00 and 0.09 for bicluster_0152 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 15:33
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-15654 MT3656 1612
Product (LegacyBRC) Product (RefSeq)
Putative CoA-transferase subunit beta Rv3552_MT3656 CoA-transferase subunit beta
Operon # Operon
2316 - -
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Geraniol degradation

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Naphthalene degradation

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Biosynthesis of secondary metabolites

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Microbial metabolism in diverse environments

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15610688 NP_218069.1 Run

growth of symbiont in host

growth of symbiont in host

The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO Category: 
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.080000 0.04

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: