P9WGG3 cobB, sir2, Rv1151c, MTCI65.18c

Title id ORF names Protein names PubMed ID Short Synonyms EnsemblBacteria
P9WGG3 NPD_MYCTU
NAD-dependent protein deacetylase of SIR2 family
MTCI65.18c NAD-dependent protein deacylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog) 9634230, 19747094, 21896569, 21627103, 21637345 cobB cobB, sir2, Rv1151c, MTCI65.18c
Binding Site Subcellular location
53 53 Substrate (By similarity)., 56 56 Substrate (By similarity)., 221 221 NAD, via amide nitrogen (By similarity). Cytoplasm (By similarity).
Domain Domain Extent InterPro Pfam ProDom Region Similarity SUPFAM
2 residues (Tyr-53 and Arg-56) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity (By similarity). DOMAIN 1 237 Deacetylase sirtuin-type. PF02146 Belongs to the sirtuin family. Class III subfamily., Contains 1 deacetylase sirtuin-type domain.
Gene3D HAMAP PANTHER Pfam PIRSF PRINTS ProDom PROSITE SMART SUPFAM
3.30.1600.10, MF_01121, PF02146 PS50305
PDB Protein Model Portal
EC number KEGG KO UniPathway
3.5.1.-
HOGENOM KEGG KO OMA OrthoDB