P9WGG3 cobB, sir2, Rv1151c, MTCI65.18c

Summary

Source: Uniprot proteome:up000001584

Title id ORF names Protein names PubMed ID Short Synonyms EnsemblBacteria
P9WGG3 NPD_MYCTU
Rv1151c
NAD-dependent protein deacetylase of SIR2 family
 MTCI65.18c NAD-dependent protein deacylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog) 9634230, 19747094, 21896569, 21627103, 21637345 cobB cobB, sir2, Rv1151c, MTCI65.18c

Last update: 06/10/2014

Structure Details

Binding Site Subcellular location
53 53 Substrate (By similarity)., 56 56 Substrate (By similarity)., 221 221 NAD, via amide nitrogen (By similarity). Cytoplasm (By similarity).

Domain/Family Details

Domain Domain Extent InterPro Pfam ProDom Region Similarity SUPFAM
2 residues (Tyr-53 and Arg-56) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity (By similarity). DOMAIN 1 237 Deacetylase sirtuin-type. PF02146 Belongs to the sirtuin family. Class III subfamily., Contains 1 deacetylase sirtuin-type domain.

Domain/Family DBs

Gene3D HAMAP PANTHER Pfam PIRSF PRINTS ProDom PROSITE SMART SUPFAM
3.30.1600.10, MF_01121, PF02146 PS50305

SSGCID Target Details

SSGCID ID

3D Details

PDB Protein Model Portal

Pathway Details

EC number KEGG KO UniPathway
3.5.1.-

Phylogenetic

HOGENOM KEGG KO OMA OrthoDB