P9WFV3 ileS, Rv1536, MTCY48.29c
Source: Uniprot proteome:up000001584
Binding Site | Subcellular location |
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622 622 ATP (By similarity). | Cytoplasm. |
Domain | InterPro | Pfam | ProDom | Region | Similarity | SUPFAM |
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IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)) (By similarity). | PF08264, PF00133 | Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. | SSF47323, SSF50677 |
SSGCID ID |
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PDB | Protein Model Portal |
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EC number | KEGG KO | UniPathway |
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6.1.1.5 |
HOGENOM | KEGG KO | OMA | OrthoDB |
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