P9WFV3 ileS, Rv1536, MTCY48.29c

Summary

Source: Uniprot proteome:up000001584

Title id ORF names Protein names PubMed ID Short Synonyms EnsemblBacteria
P9WFV3 SYI_MYCTU
Rv1536
Isoleucyl-tRNA synthetase (EC 6.1.1.5)
 MTCY48.29c Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) 9634230, 8756461 ileS ileS, Rv1536, MTCY48.29c

Last update: 06/10/2014

Structure Details

Binding Site Subcellular location
622 622 ATP (By similarity). Cytoplasm.

Domain/Family Details

Domain InterPro Pfam ProDom Region Similarity SUPFAM
IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)) (By similarity). PF08264, PF00133 Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. SSF47323, SSF50677

Domain/Family DBs

Gene3D HAMAP PANTHER Pfam PIRSF PRINTS ProDom PROSITE SMART SUPFAM
1.10.730.10, 3.40.50.620, 3.90.740.10, MF_02003, PF08264, PF00133 PR00984, PS00178 SSF47323, SSF50677

SSGCID Target Details

SSGCID ID

3D Details

PDB Protein Model Portal

Pathway Details

EC number KEGG KO UniPathway
6.1.1.5

Phylogenetic

HOGENOM KEGG KO OMA OrthoDB