P9WHM7 purH, Rv0957, MTCY10D7.17c | MTB Network Portal

Summary

Source: Uniprot proteome:up000001584

Title	id	ORF names	Protein names	PubMed ID	Short	Synonyms	EnsemblBacteria
P9WHM7 PUR9_MYCTU	Rv0957 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	MTCY10D7.17c	Bifunctional purine biosynthesis protein PurH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)]	9634230	purH	purH, Rv0957, MTCY10D7.17c

Structure Details

Domain/Family Details

Domain	InterPro	Pfam	ProDom	Region	Similarity	SUPFAM
The IMP cyclohydrolase activity resides in the N-terminal region (By similarity).		PF01808, PF02142			Belongs to the PurH family.	SSF52335, SSF53927

Domain/Family DBs

Gene3D	HAMAP	PANTHER	Pfam	PIRSF	PRINTS	ProDom	PROSITE	SMART	SUPFAM
3.40.140.20, 3.40.50.1380,	MF_00139,		PF01808, PF02142	PIRSF000414,				SM00798, SM00851,	SSF52335, SSF53927

SSGCID Target Details

SSGCID ID

3D Details

PDB	Protein Model Portal

Pathway Details

EC number	KEGG KO	UniPathway
2.1.2.3, 3.5.4.10		Purine metabolism, IMP biosynthesis via de novo pathway, 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1., Purine metabolism, IMP biosynthesis via de novo pathway, IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Phylogenetic

HOGENOM	KEGG KO	OMA	OrthoDB