Organism : Bacillus cereus ATCC14579 | Module List :
Alanine racemase (NCBI ptt file)
Functional Annotations (6)
|Alanine racemase||cog/ cog|
|alanine metabolic process||go/ biological_process|
|alanine racemase activity||go/ molecular_function|
|D-Alanine metabolism||kegg/ kegg pathway|
|Metabolic pathways||kegg/ kegg pathway|
Regulation information for BC0264(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for BC0264
Module neighborhood information for BC0264
|Gene||Common Name||Description||Module membership|
|BC0044||BC0044||Sec-independent secretion protein tatD (NCBI ptt file)||72, 225|
|BC0074||BC0074||33 kDa chaperonin (NCBI ptt file)||240, 518|
|BC0076||BC0076||Para-aminobenzoate synthase component I (NCBI ptt file)||493, 518|
|BC0077||BC0077||Anthranilate synthase component II (NCBI ptt file)||493, 518|
|BC0078||BC0078||4-amino-4-deoxychorismate lyase (NCBI ptt file)||493, 518|
|BC0079||BC0079||Dihydropteroate synthase (NCBI ptt file)||493, 518|
|BC0080||BC0080||Dihydroneopterin aldolase (NCBI ptt file)||493, 518|
|BC0081||BC0081||2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (NCBI ptt file)||493, 518|
|BC0082||BC0082||Transcriptional regulator, Xre family (NCBI ptt file)||493, 518|
|BC0083||BC0083||Nif3 family protein (NCBI ptt file)||493, 518|
|BC0196||BC0196||ABC transporter permease protein (NCBI ptt file)||72, 408|
|BC0263||BC0263||hypothetical protein (NCBI ptt file)||276, 518|
|BC0264||BC0264||Alanine racemase (NCBI ptt file)||72, 518|
|BC0327||BC0327||Phosphorybosylformylglycinamidine synthetase, PurS component (NCBI ptt file)||72, 524|
|BC0328||BC0328||Phosphoribosylformylglycinamidine synthase (NCBI ptt file)||72, 524|
|BC0353||BC0353||hypothetical protein (NCBI ptt file)||72, 478|
|BC0358||BC0358||Quaternary ammonium compound-resistance protein (NCBI ptt file)||72, 85|
|BC0395||BC0395||Metal-dependent hydrolase (NCBI ptt file)||72, 330|
|BC0411||BC0411||hypothetical protein (NCBI ptt file)||72, 248|
|BC0802||BC0802||Alcohol dehydrogenase (NCBI ptt file)||72, 197|
|BC0979||BC0979||Dihydroxyacetone kinase (NCBI ptt file)||72, 199|
|BC1069||BC1069||Ferrochelatase (NCBI ptt file)||72, 311|
|BC1202||BC1202||Serine/threonine protein phosphatase (NCBI ptt file)||72, 218|
|BC2025||BC2025||hypothetical protein (NCBI ptt file)||72, 194|
|BC2046||BC2046||CBS domain containing protein (NCBI ptt file)||72, 473|
|BC2174||BC2174||Phosphoglycolate phosphatase (NCBI ptt file)||72, 316|
|BC2462||BC2462||Ribosomal-protein-serine acetyltransferase (NCBI ptt file)||72, 266|
|BC2701||BC2701||hypothetical protein (NCBI ptt file)||72, 478|
|BC2702||BC2702||hypothetical protein (NCBI ptt file)||72, 478|
|BC2830||BC2830||DNA-binding protein (NCBI ptt file)||72, 481|
|BC2877||BC2877||Zwittermicin A resistance protein ZmaR (NCBI ptt file)||52, 72|
|BC3014||BC3014||hypothetical protein (NCBI ptt file)||72, 453|
|BC3174||BC3174||Short chain type dehydrogenase/reductase (NCBI ptt file)||72, 89|
|BC3216||BC3216||1-aminocyclopropane-1-carboxylate deaminase (NCBI ptt file)||72, 453|
|BC3246||BC3246||hypothetical protein (NCBI ptt file)||72, 427|
|BC3316||BC3316||Regulatory protein (NCBI ptt file)||72, 146|
|BC3365||BC3365||hypothetical protein (NCBI ptt file)||72, 359|
|BC3476||BC3476||Transcriptional regulators, LysR family (NCBI ptt file)||72, 407|
|BC3477||BC3477||Quinone oxidoreductase (NCBI ptt file)||72, 76|
|BC3853||BC3853||ATP-dependent DNA helicase recG (NCBI ptt file)||240, 518|
|BC3926||BC3926||ATP-dependent protease La (NCBI ptt file)||451, 518|
|BC3927||BC3927||Serine protease (NCBI ptt file)||451, 518|
|BC3989||BC3989||Diguanylate cyclase/phosphodiesterase domain 2 (EAL) (NCBI ptt file)||72, 85|
|BC4165||BC4165||Sigma-54-dependent transcriptional activator (NCBI ptt file)||277, 518|
|BC4176||BC4176||1-deoxy-D-xylulose 5-phosphate synthase (NCBI ptt file)||451, 518|
|BC4223||BC4223||hypothetical protein (NCBI ptt file)||72, 279|
|BC4255||BC4255||Isochorismatase (NCBI ptt file)||72, 238|
|BC4260||BC4260||Glucokinase (NCBI ptt file)||72, 175|
|BC4303||BC4303||putative stage IV sporulation protein (NCBI ptt file)||17, 518|
|BC4305||BC4305||hypothetical Cytosolic Protein (NCBI ptt file)||63, 72|
|BC4404||BC4404||Cobalt-zinc-cadmium resistance protein czcD (NCBI ptt file)||72, 364|
|BC4485||BC4485||hypothetical Cytosolic Protein (NCBI ptt file)||59, 518|
|BC4486||BC4486||hypothetical protein (NCBI ptt file)||59, 518|
|BC4487||BC4487||Superfamily I DNA and RNA helicases (NCBI ptt file)||518, 524|
|BC4586||BC4586||Formamidopyrimidine-DNA glycosylase (NCBI ptt file)||164, 518|
|BC4901||BC4901||Aromatic amino acid aminotransferase (NCBI ptt file)||484, 518|
|BC5436||BC5436||Peptide methionine sulfoxide reductase (NCBI ptt file)||72, 427|
|BC5471||BC5471||LSU ribosomal protein L9P (NCBI ptt file)||493, 518|
|BC5472||BC5472||phosphoesterase, DHH family protein (NCBI ptt file)||493, 518|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
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