Organism : Bacillus cereus ATCC14579 | Module List :
BC0648

ECF-type sigma factor negative effector (NCBI ptt file)

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC0648
(Mouseover regulator name to see its description)

BC0648 is regulated by 18 influences and regulates 65 modules.
Regulators for BC0648 (18)
Regulator Module Operator
BC0648 50 tf
BC2742 50 tf
BC4211 50 tf
BC4650 50 tf
BC4703 50 tf
BC5481 50 tf
BC0648 60 tf
BC0954 60 tf
BC1356 60 tf
BC1731 60 tf
BC2903 60 tf
BC2904 60 tf
BC2914 60 tf
BC4001 60 tf
BC4076 60 tf
BC4256 60 tf
BC4652 60 tf
BC4703 60 tf
Regulated by BC0648 (65)
Module Residual Genes
5 0.37 6
13 0.63 11
15 0.44 17
19 0.33 19
21 0.35 14
36 0.23 16
38 0.38 15
47 0.47 29
50 0.40 26
51 0.40 16
60 0.42 31
73 0.43 25
74 0.42 23
84 0.49 19
95 0.23 14
96 0.60 20
107 0.29 16
108 0.48 19
120 0.42 25
123 0.48 23
132 0.22 15
136 0.40 22
144 0.30 14
158 0.56 33
162 0.47 24
172 0.31 14
174 0.45 15
178 0.31 19
181 0.41 20
185 0.39 6
194 0.47 23
200 0.22 14
206 0.50 6
213 0.44 31
217 0.49 37
239 0.39 12
255 0.39 16
273 0.32 18
280 0.58 13
293 0.54 21
302 0.48 20
307 0.41 16
322 0.36 23
324 0.37 13
340 0.51 18
363 0.43 19
385 0.57 26
414 0.57 33
418 0.27 16
425 0.39 21
435 0.34 12
436 0.33 21
437 0.37 21
438 0.43 25
444 0.26 13
448 0.30 12
455 0.53 28
459 0.47 15
462 0.43 30
470 0.23 15
480 0.44 18
489 0.45 27
492 0.38 23
498 0.38 25
502 0.43 21
Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4020 7.70e-04 AGGAgG
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4021 4.00e+04 CAGccAG
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4040 2.70e+00 GagGGAg
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4041 3.20e+04 GGAGGC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC0648

Warning: No Functional annotations were found!

Module neighborhood information for BC0648

BC0648 has total of 54 gene neighbors in modules 50, 60
Gene neighbors (54)
Gene Common Name Description Module membership
BC0226 BC0226 hypothetical protein (NCBI ptt file) 60, 410
BC0577 BC0577 Two-component sensor kinase yufL (NCBI ptt file) 50, 462
BC0648 BC0648 ECF-type sigma factor negative effector (NCBI ptt file) 50, 60
BC0896 BC0896 S-layer protein / Peptidoglycan endo-beta-N-acetylglucosaminidase (NCBI ptt file) 50, 492
BC0943 BC0943 hypothetical protein (NCBI ptt file) 50, 492
BC1019 BC1019 phosphoesterase (NCBI ptt file) 50, 524
BC1060 BC1060 Collagen adhesion protein (NCBI ptt file) 60, 293
BC1072 BC1072 Endonuclease/Exonuclease/phosphatase family protein (NCBI ptt file) 60, 517
BC1447 BC1447 hypothetical protein (NCBI ptt file) 19, 60
BC1629 BC1629 Chemotaxis protein cheC (NCBI ptt file) 50, 83
BC1630 BC1630 hypothetical protein (NCBI ptt file) 50, 83
BC1631 BC1631 hypothetical protein (NCBI ptt file) 50, 76
BC1635 BC1635 hypothetical protein (NCBI ptt file) 50, 492
BC1636 BC1636 Flagellar hook-associated protein 1 (NCBI ptt file) 50, 492
BC1637 BC1637 Flagellar hook-associated protein 3 (NCBI ptt file) 50, 492
BC1638 BC1638 Flagellar hook-associated protein 2 (NCBI ptt file) 50, 492
BC1641 BC1641 Flagellar basal-body rod protein flgB (NCBI ptt file) 50, 492
BC1642 BC1642 Flagellar basal-body rod protein flgC (NCBI ptt file) 50, 492
BC1643 BC1643 Flagellar hook-basal body complex protein fliE (NCBI ptt file) 50, 492
BC1644 BC1644 Flagellar M-ring protein fliF (NCBI ptt file) 50, 492
BC1645 BC1645 Flagellar motor switch protein fliG (NCBI ptt file) 50, 492
BC1647 BC1647 Flagellum-specific ATP synthase (NCBI ptt file) 50, 492
BC1649 BC1649 None 50, 492
BC1650 BC1650 Basal-body rod modification protein flgD (NCBI ptt file) 50, 492
BC1651 BC1651 Flagellar hook protein flgE (NCBI ptt file) 50, 492
BC1879 BC1879 Transglycosylase (NCBI ptt file) 50, 60
BC1955 BC1955 Multidrug resistance ABC transporter ATP-binding and permease protein (NCBI ptt file) 60, 375
BC2443 BC2443 Transcriptional regulator, XRE family (NCBI ptt file) 50, 60
BC2723 BC2723 D-amino acid dehydrogenase small subunit (NCBI ptt file) 50, 283
BC2870 BC2870 Oligoendopeptidase F (NCBI ptt file) 50, 444
BC2882 BC2882 hypothetical Cytosolic Protein (NCBI ptt file) 60, 369
BC2902 BC2902 ABC transporter ATP-binding protein (NCBI ptt file) 60, 341
BC2904 BC2904 Transcriptional regulator, GntR family (NCBI ptt file) 30, 60
BC2913 BC2913 hypothetical protein (NCBI ptt file) 60, 485
BC2914 BC2914 Transcriptional regulator, TetR family (NCBI ptt file) 60, 485
BC3056 BC3056 hypothetical protein (NCBI ptt file) 60, 181
BC3085 BC3085 None 60, 277
BC3088 BC3088 Metal-dependent hydrolase (NCBI ptt file) 60, 517
BC3273 BC3273 hypothetical protein (NCBI ptt file) 60, 502
BC3276 BC3276 hypothetical protein (NCBI ptt file) 60, 172
BC3277 BC3277 hypothetical Cytosolic Protein (NCBI ptt file) 60, 141
BC3678 BC3678 Multidrug resistance ABC transporter ATP-binding and permease protein (NCBI ptt file) 60, 462
BC3679 BC3679 Multidrug resistance ABC transporter ATP-binding and permease protein (NCBI ptt file) 60, 462
BC4027 BC4027 hypothetical protein (NCBI ptt file) 60, 485
BC4028 BC4028 hypothetical Membrane Spanning Protein (NCBI ptt file) 60, 404
BC4076 BC4076 Acetoin transport repressor (NCBI ptt file) 60, 75
BC4172 BC4172 Stage IV sporulation protein B (NCBI ptt file) 60, 136
BC4264 BC4264 Phosphoglucomutase (NCBI ptt file) 60, 460
BC4299 BC4299 Diacylglycerol kinase (NCBI ptt file) 60, 67
BC4324 BC4324 ComE operon protein 1 (NCBI ptt file) 19, 60
BC4770 BC4770 Sporulation kinase (NCBI ptt file) 60, 104
BC4771 BC4771 Sporulation kinase (NCBI ptt file) 60, 223
BC5192 BC5192 Competence protein F (NCBI ptt file) 60, 67
BC5262 BC5262 Two-component response regulator (NCBI ptt file) 50, 283
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC0648
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend