Organism : Bacillus cereus ATCC14579 | Module List :
BC2903

Transcriptional regulator, GntR family (NCBI ptt file)

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC2903
(Mouseover regulator name to see its description)

BC2903 is regulated by 24 influences and regulates 33 modules.
Regulators for BC2903 (24)
Regulator Module Operator
BC0586 411 tf
BC1059 411 tf
BC1477 411 tf
BC1698 411 tf
BC1884 411 tf
BC2903 411 tf
BC3449 411 tf
BC3588 411 tf
BC3904 411 tf
BC3961 411 tf
BC4222 411 tf
BC4672 411 tf
BC0213 498 tf
BC0648 498 tf
BC0954 498 tf
BC1059 498 tf
BC1335 498 tf
BC1531 498 tf
BC2386 498 tf
BC2903 498 tf
BC3155 498 tf
BC3320 498 tf
BC5175 498 tf
BC5251 498 tf

Warning: BC2903 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4732 3.80e+03 gaAggAgaaA.ag
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4733 1.70e+04 GGcGTGAA
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4906 2.50e-04 AaggaGGa
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4907 5.00e+01 TtttGgaAaaGg
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC2903

Warning: No Functional annotations were found!

Module neighborhood information for BC2903

BC2903 has total of 44 gene neighbors in modules 411, 498
Gene neighbors (44)
Gene Common Name Description Module membership
BC0200 BC0200 hypothetical protein (NCBI ptt file) 363, 498
BC0213 BC0213 Transcriptional regulator, AraC family (NCBI ptt file) 363, 498
BC0214 BC0214 hypothetical Membrane Spanning Protein (NCBI ptt file) 123, 498
BC0343 BC0343 hypothetical Membrane Spanning Protein (NCBI ptt file) 411, 436
BC0375 BC0375 Methyltransferase (NCBI ptt file) 310, 411
BC0852 BC0852 Quaternary ammonium compound-resistance protein (NCBI ptt file) 369, 498
BC0853 BC0853 Quaternary ammonium compound-resistance protein (NCBI ptt file) 80, 498
BC1064 BC1064 hypothetical Membrane Spanning Protein (NCBI ptt file) 435, 498
BC1267 BC1267 hypothetical protein (NCBI ptt file) 4, 411
BC1271 BC1271 hypothetical protein (NCBI ptt file) 238, 411
BC1292 BC1292 IG hypothetical 18022 (NCBI ptt file) 19, 498
BC1334 BC1334 hypothetical Exported Protein (NCBI ptt file) 80, 498
BC1335 BC1335 Stage 0 sporulation regulatory protein (NCBI ptt file) 19, 498
BC1360 BC1360 Bacitracin transport permease protein BCRB (NCBI ptt file) 363, 498
BC1433 BC1433 hypothetical protein (NCBI ptt file) 363, 498
BC1613 BC1613 Zn-dependent hydrolase (NCBI ptt file) 123, 498
BC1690 BC1690 D-alanyl-D-alanine carboxypeptidase (NCBI ptt file) 132, 411
BC1875 BC1875 Phage protein (NCBI ptt file) 342, 411
BC2335 BC2335 Catabolite gene activator (NCBI ptt file) 153, 411
BC2903 BC2903 Transcriptional regulator, GntR family (NCBI ptt file) 411, 498
BC3013 BC3013 D-alanyl-D-alanine carboxypeptidase (NCBI ptt file) 411, 435
BC3090 BC3090 hypothetical protein (NCBI ptt file) 341, 498
BC3193 BC3193 hypothetical protein (NCBI ptt file) 363, 498
BC3258 BC3258 hypothetical Cytosolic Protein (NCBI ptt file) 411, 435
BC3260 BC3260 hypothetical protein (NCBI ptt file) 114, 411
BC3266 BC3266 hypothetical protein (NCBI ptt file) 392, 411
BC3267 BC3267 hypothetical protein (NCBI ptt file) 404, 411
BC3268 BC3268 Syd protein (NCBI ptt file) 404, 411
BC3270 BC3270 hypothetical Membrane Spanning Protein (NCBI ptt file) 411, 435
BC3288 BC3288 hypothetical Cytosolic Protein (NCBI ptt file) 114, 411
BC3320 BC3320 Transcriptional regulator, MarR family (NCBI ptt file) 486, 498
BC3444 BC3444 hypothetical protein (NCBI ptt file) 128, 498
BC3619 BC3619 hypothetical protein (NCBI ptt file) 498, 509
BC3702 BC3702 Antirepressor (NCBI ptt file) 239, 498
BC3760 BC3760 6-phospho-beta-glucosidase (NCBI ptt file) 363, 498
BC4100 BC4100 5'-nucleotidase (NCBI ptt file) 363, 498
BC4220 BC4220 ABC transporter permease protein (NCBI ptt file) 83, 411
BC4222 BC4222 Transcriptional regulator, GntR family (NCBI ptt file) 83, 411
BC4534 BC4534 hypothetical protein (NCBI ptt file) 310, 411
BC4786 BC4786 hypothetical Cytosolic Protein (NCBI ptt file) 456, 498
BC4787 BC4787 hypothetical protein (NCBI ptt file) 363, 498
BC4827 BC4827 hypothetical protein (NCBI ptt file) 435, 498
BC5114 BC5114 hypothetical protein (NCBI ptt file) 489, 498
BC5286 BC5286 Transcriptional regulator with ABC transporter ATP-binding domain and LytTR DNA-binding domain (NCBI ptt file) 411, 454
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC2903
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend