Organism : Bacillus cereus ATCC14579 | Module List :
BC1966

Homoserine kinase (NCBI ptt file)

CircVis
Functional Annotations (9)
Function System
Homoserine kinase cog/ cog
homoserine kinase activity go/ molecular_function
ATP binding go/ molecular_function
threonine metabolic process go/ biological_process
phosphorylation go/ biological_process
Glycine serine and threonine metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
thrB tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC1966
(Mouseover regulator name to see its description)

BC1966 is regulated by 22 influences and regulates 0 modules.
Regulators for BC1966 (22)
Regulator Module Operator
BC0776 412 tf
BC0806 412 tf
BC1113 412 tf
BC3648 412 tf
BC3903 412 tf
BC4240 412 tf
BC4714 412 tf
BC4902 412 tf
BC5250 412 tf
BC5361 412 tf
BC5363 412 tf
BC0073 379 tf
BC0854 379 tf
BC1114 379 tf
BC1819 379 tf
BC1841 379 tf
BC2631 379 tf
BC3648 379 tf
BC4902 379 tf
BC5250 379 tf
BC5361 379 tf
BC5363 379 tf

Warning: BC1966 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4668 1.60e-63 AAttaGGGTGGtAcCgCGgataaa
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4669 1.30e-28 ctCGTCCCTattttaggga..gg
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4734 3.40e-61 AattagGGTGGtAcCgCGgg
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4735 2.10e-26 ctCGTCCcTtttta..gaaaagga
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC1966

BC1966 is enriched for 9 functions in 3 categories.
Enrichment Table (9)
Function System
Homoserine kinase cog/ cog
homoserine kinase activity go/ molecular_function
ATP binding go/ molecular_function
threonine metabolic process go/ biological_process
phosphorylation go/ biological_process
Glycine serine and threonine metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
thrB tigr/ tigrfam
Module neighborhood information for BC1966

BC1966 has total of 33 gene neighbors in modules 379, 412
Gene neighbors (33)
Gene Common Name Description Module membership
BC0017 BC0017 Seryl-tRNA synthetase (NCBI ptt file) 379, 412
BC0439 BC0439 Prolyl-tRNA synthetase (NCBI ptt file) 297, 379
BC1232 BC1232 Anthranilate synthase component I (NCBI ptt file) 83, 412
BC1430 BC1430 Sodium-dependent tryptophan transporter (NCBI ptt file) 412, 479
BC1441 BC1441 Branched-chain amino acid transport system carrier protein (NCBI ptt file) 139, 412
BC1746 BC1746 Aspartate--ammonia ligase (NCBI ptt file) 379, 412
BC1767 BC1767 Sodium-dependent serine transporter (NCBI ptt file) 412, 428
BC1964 BC1964 Homoserine dehydrogenase (NCBI ptt file) 297, 379
BC1965 BC1965 Threonine synthase (NCBI ptt file) 379, 412
BC1966 BC1966 Homoserine kinase (NCBI ptt file) 379, 412
BC2164 BC2164 Isoleucyl-tRNA synthetase, mupirocin resistant (NCBI ptt file) 379, 412
BC2169 BC2169 Aspartyl-tRNA synthetase (NCBI ptt file) 297, 379
BC2322 BC2322 Threonyl-tRNA synthetase (NCBI ptt file) 297, 379
BC2535 BC2535 Class 1 lysyl-tRNA synthetase (NCBI ptt file) 297, 379
BC2939 BC2939 Arogenate dehydrogenase (NCBI ptt file) 297, 379
BC2940 BC2940 Histidinol-phosphate aminotransferase (NCBI ptt file) 297, 379
BC2941 BC2941 Chorismate synthase (NCBI ptt file) 297, 379
BC2942 BC2942 Chorismate mutase (NCBI ptt file) 379, 412
BC2975 BC2975 Glutamate 5-kinase (NCBI ptt file) 379, 412
BC3340 BC3340 tryptophanyl-tRNA synthetase (RefSeq) 163, 412
BC4121 BC4121 Tyrosine transporter (NCBI ptt file) 139, 412
BC4383 BC4383 Alanyl-tRNA synthetase (NCBI ptt file) 379, 412
BC4397 BC4397 Aspartyl-tRNA synthetase (NCBI ptt file) 379, 474
BC4398 BC4398 Histidyl-tRNA synthetase (NCBI ptt file) 379, 412
BC4465 BC4465 Valyl-tRNA synthetase (NCBI ptt file) 379, 412
BC4550 BC4550 Threonine transporter (NCBI ptt file) 379, 405
BC4559 BC4559 Asparaginyl-tRNA synthetase (NCBI ptt file) 100, 412
BC4560 BC4560 Phenylalanyl-tRNA synthetase beta chain (NCBI ptt file) 412, 417
BC4561 BC4561 Phenylalanyl-tRNA synthetase alpha chain (NCBI ptt file) 412, 417
BC4576 BC4576 Threonyl-tRNA synthetase (NCBI ptt file) 379, 412
BC4737 BC4737 Leucyl-tRNA synthetase (NCBI ptt file) 379, 412
BC5013 BC5013 Threonine transporter (NCBI ptt file) 379, 412
BC5057 BC5057 2,5-diketo-D-gluconic acid reductase (NCBI ptt file) 93, 379
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC1966
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend