Organism : Bacillus cereus ATCC14579 | Module List :
BC2434

Transcriptional regulator, MarR family (NCBI ptt file)

CircVis
Functional Annotations (4)
Function System
Transcriptional regulators cog/ cog
sequence-specific DNA binding transcription factor activity go/ molecular_function
intracellular go/ cellular_component
regulation of transcription, DNA-dependent go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC2434
(Mouseover regulator name to see its description)

BC2434 is regulated by 20 influences and regulates 20 modules.
Regulators for BC2434 (20)
Regulator Module Operator
BC0099 483 tf
BC0518 483 tf
BC0954 483 tf
BC1302 483 tf
BC1710 483 tf
BC2434 483 tf
BC3922 483 tf
BC4211 483 tf
BC4314 483 tf
BC4703 483 tf
BC0116 322 tf
BC0598 322 tf
BC0648 322 tf
BC0954 322 tf
BC2434 322 tf
BC3449 322 tf
BC3922 322 tf
BC4499 322 tf
BC4652 322 tf
BC4703 322 tf

Warning: BC2434 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4558 3.60e-06 AGGGGG
Loader icon
4559 1.00e+03 gatgcg.aAaaTgCt.TcT
Loader icon
4876 2.60e-02 aAGGaGGa
Loader icon
4877 1.20e+00 gtTTgaCctTttTTgACca
Loader icon
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC2434

BC2434 is enriched for 4 functions in 3 categories.
Enrichment Table (4)
Function System
Transcriptional regulators cog/ cog
sequence-specific DNA binding transcription factor activity go/ molecular_function
intracellular go/ cellular_component
regulation of transcription, DNA-dependent go/ biological_process
Module neighborhood information for BC2434

BC2434 has total of 45 gene neighbors in modules 322, 483
Gene neighbors (45)
Gene Common Name Description Module membership
BC0070 BC0070 Cell cycle protein MesJ (NCBI ptt file) 483, 491
BC0099 BC0099 Transcriptional regulator ctsR (NCBI ptt file) 335, 483
BC0100 BC0100 ClpC ATPase (NCBI ptt file) 335, 483
BC0101 BC0101 Arginine kinase (NCBI ptt file) 335, 483
BC0102 BC0102 Negative regulator of genetic competence clpC/mecB (NCBI ptt file) 335, 483
BC0103 BC0103 DNA repair protein RadA (NCBI ptt file) 483, 527
BC0104 BC0104 DNA-binding protein (NCBI ptt file) 483, 527
BC0195 BC0195 3-oxoacyl-[acyl-carrier protein] reductase (NCBI ptt file) 335, 483
BC0376 BC0376 Alkyl hydroperoxide reductase subunit F (NCBI ptt file) 335, 483
BC0377 BC0377 Alkyl hydroperoxide reductase C22 (NCBI ptt file) 335, 483
BC0442 BC0442 Tellurium resistance protein terD (NCBI ptt file) 43, 322
BC0443 BC0443 Tellurium resistance protein terD (NCBI ptt file) 43, 322
BC0444 BC0444 Tellurium resistance protein terD (NCBI ptt file) 43, 322
BC0503 BC0503 hypothetical Membrane Spanning Protein (NCBI ptt file) 335, 483
BC1165 BC1165 hydrolase (HAD superfamily) (NCBI ptt file) 335, 483
BC1168 BC1168 ClpB protein (NCBI ptt file) 335, 483
BC1224 BC1224 Acetyltransferase (NCBI ptt file) 322, 328
BC1225 BC1225 2'-5' RNA ligase (NCBI ptt file) 322, 328
BC1619 BC1619 Oxygen-insensitive NADPH nitroreductase (NCBI ptt file) 439, 483
BC1952 BC1952 Nitroreductase family protein (NCBI ptt file) 335, 483
BC1959 BC1959 Aminoglycoside 6-adenylyltransferase (NCBI ptt file) 98, 483
BC2101 BC2101 Formate--tetrahydrofolate ligase (NCBI ptt file) 322, 511
BC2214 BC2214 Small heat shock protein (NCBI ptt file) 335, 483
BC2434 BC2434 Transcriptional regulator, MarR family (NCBI ptt file) 322, 483
BC2435 BC2435 Phosphoglycerate mutase (NCBI ptt file) 322, 483
BC2436 BC2436 SpoIISA like protein (NCBI ptt file) 194, 322
BC3723 BC3723 hypothetical protein (NCBI ptt file) 335, 483
BC3833 BC3833 Succinyl-CoA synthetase alpha chain (NCBI ptt file) 302, 322
BC3834 BC3834 Succinyl-CoA synthetase beta chain (NCBI ptt file) 302, 322
BC4211 BC4211 Transcriptional regulator, LacI family (NCBI ptt file) 335, 483
BC4224 BC4224 Glycine dehydrogenase [decarboxylating] (NCBI ptt file) 322, 328
BC4225 BC4225 Glycine dehydrogenase [decarboxylating] (NCBI ptt file) 322, 328
BC4226 BC4226 Aminomethyltransferase (NCBI ptt file) 322, 328
BC4516 BC4516 Succinate dehydrogenase iron-sulfur protein (NCBI ptt file) 322, 328
BC4517 BC4517 Succinate dehydrogenase flavoprotein subunit (NCBI ptt file) 322, 328
BC4518 BC4518 Succinate dehydrogenase cytochrome b558 subunit (NCBI ptt file) 322, 328
BC4571 BC4571 Deblocking aminopeptidase (NCBI ptt file) 322, 483
BC4592 BC4592 Malate dehydrogenase (NCBI ptt file) 43, 322
BC4593 BC4593 Isocitrate dehydrogenase [NADP] (NCBI ptt file) 43, 322
BC4594 BC4594 Citrate synthase (NCBI ptt file) 43, 322
BC4749 BC4749 ABC transporter permease protein (NCBI ptt file) 98, 483
BC4921 BC4921 Cytosol aminopeptidase (NCBI ptt file) 107, 322
BC4926 BC4926 Thioredoxin reductase (NCBI ptt file) 107, 322
BC5152 BC5152 ATP-dependent Clp protease proteolytic subunit (NCBI ptt file) 335, 483
BC5240 BC5240 hypothetical protein (NCBI ptt file) 335, 483
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC2434
Please add your comments for this gene by using the form below. Your comments will be publicly available.

comments powered by Disqus

Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend